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Epigenetic Factors in the Neoplastic Response to Polyoma Virus

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Abstract

One could hardly speak of epigenetic matters before an audience at the University of Chicago without taking cognizance of the outstanding contributions that have come from that institution to the field of epigenetics. Among them, and quite relevant to the work described in this report, are the classical works of Dr. F. R. Lillie and Dr. Hsi Wang on the formation of feathers. In a series of experiments that lead to the delineation of the specific morphogenetic functions of the epithelial and the mesenchymal components of feather follicles (1), Dr. Lillie and Dr. Wang developed a pattern of analysis that has found increasing use in developmental biology, and is beginning to find application in experimental oncology. It is safe to predict that the debt of oncologists to those original investigations will continue to increase.

The authors are grateful to Mr. Gebhard Gsell for photographic assistance; to Mr. J. P. Summerour for technical assistance in the culture work; and to Mr. J. Albrecht and staff for the histologic preparations.

National Institutes of Health, Public Health Service, United States Department of Health, Education and Welfare.

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W. H. Kirsten

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Dawe, C.J., Main, J.H.P., Slatick, M.S., Morgan, W.D. (1966). Epigenetic Factors in the Neoplastic Response to Polyoma Virus. In: Kirsten, W.H. (eds) Malignant Transformation by Viruses. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87402-4_5

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  • DOI: https://doi.org/10.1007/978-3-642-87402-4_5

  • Publisher Name: Springer, Berlin, Heidelberg

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