Abstract
Numerical and structural alterations of the karyotype are secondary phenomena featured among many, if not all, continuously propagated normal, malignant, and virus-transformed cell lines. Dr. Moorhead has described the varied events during in vitro progression of human and Syrian hamster virus-transformed cells. His efforts to associate cytogenetic alterations with increased oncogenicity must, however, be restricted to the species employed for reasons I will describe below. The degree of aneuploidy need not be extensive, in order for experimental cells to proliferate more rapidly, or to attain the status of a permanent cell line. I sense that Dr. Moorhead will agree to the statement that a subtle, stable pseudodiploid condition is more conducive to the development of a cell or tumor line than many complex heteroploid conditions (Yerganian, et al., 1960; Moorhead, 1965).
1 Supported by grants from the Damon Runyon Memorial Fund (293), U.S.P.H.S. CA-08378 and C-6516, National Cancer Institute, and National Science Foundation (GB4558).
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Yerganian, G. (1966). Relative Growth and Oncogenic Potential of Normal, Malignant, and Virus-Transformed Euploid Cells of Dwarf Species of Hamster. In: Kirsten, W.H. (eds) Malignant Transformation by Viruses. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87402-4_14
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