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Malignant Transformation by Viruses pp 77–94Cite as

Complementation Between Defective Oncogenic Viruses

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Abstract

Complementation involves functional interaction between two viruses which results in replication under normally inhibitory conditions. A virus which requires complementation for replication is usually defective in some portion of its genome. However, some viruses competent to grow unilaterally in one cell may be incompetent in a second cell and thus require a second virus to furnish help for some step in the replicative cycle. Though complementation has been studied extensively with bacterial viruses (2, 20, 40, 43) and with one plant virus (15, 33), relatively few such studies have been carried out with animal viruses.

The author wishes to thank his many collaborators for their contributions to the research described in this article. The support, advice, and encouragement of Dr. Joseph L. Melnick continues to catalyze the progress of these studies. This investigation was supported in part by Public Health Service Grants CA-04600 from the National Cancer Institute and AI 05382 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Public Health Service.

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  1. Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas, USA

    Fred Rapp

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  1. Fred Rapp
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W. H. Kirsten

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Rapp, F. (1966). Complementation Between Defective Oncogenic Viruses. In: Kirsten, W.H. (eds) Malignant Transformation by Viruses. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87402-4_11

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  • DOI: https://doi.org/10.1007/978-3-642-87402-4_11

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