Abstract
The cellular antigens induced by tumor viruses that Dr. Habel has just illustrated, appear during and because of a specific interaction of the viral genome with the host cells. This we can state with unquestionable certainty. Whether their presence in virus-free cells indicates persistence of the viral genome or a fraction of it, we cannot state with equal certainty since attempts to obtain independent proofs of viral genome integration in the case of SV40 and polyoma virus have given, at best, equivocal results (2, 12, 13). The alternate hypothesis, that the antigens represent products of the cell genome whose synthesis is derepressed as a consequence of a specific interaction with the virus, appears improbable but has not yet been completely excluded. We have to remember that there are at least two well-documented cases in which antigens, present in some organs during embryonal life, disappear in the adult, to reappear again when a neoplastic process has occurred. One is the case of the antigen in rat liver hepatomas (1), the other is the antigen observed in colon carcinomas of man (7). These are therefore examples in which the expression of specific cellular antigens is modulated by differentiation and growth.
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References
Abelev, G. I.: Study of the antigenic structure of tumors. Acta Unio contra Cancrum 19:80–82, 1963.
Axelrod, D., Habel, K., and Bolton, E. T.: Polyoma virus genetic material in a virus-free polyoma-induced tumor. Science 146:1466–1468, 1964.
Defendí, V.: Transformation in vitro of mammalian cells by polyoma and Simian 40 viruses. Progr. Exp. Tumor Res. 8: 1965 (in press), Karger, Basel.
Defendi, V., Jensen, F., and Sauer, G.: Unpublished observations.
Dulbecco, R., Hartwell, L. H., and Vogt, M.: Induction of cellular DNA synthesis by polyoma virus. Proc. Nat. Sci. (Washington) 53:403–410, 1965.
Eddy, B. E., Grubbs, G. E., and Young, R. D.: Tumor immunity in hamsters infected with adenovirus Type 11 or Simian virus 40. Proc. Soc. Exptl. Biol. Med. 117:575–579, 1964.
Gold, P., and Freedman, S. O.: Specific carcinoembryonic antigens of the human digestive system. J. Exp. Med. 122:467–481, 1965.
Goldner, H., Girardi, A. S., Larson, V. M., and Hilleman, M. R.: Interruption of SV40 virus tumorigenesis using irradiated homologous tumor antigen. Proc. Soc. Exptl. Biol. Med. 117:851–857, 1964.
Rowe, W. P., and Baum, S. G.: Evidence for a possible genetic hybrid between adenovirus Type 7 and SV40 viruses. Proc. Natl. Acad. Sci. (Washington) 52:1340–1347, 1964.
Sauer, G., and Defendi, V.: Stimulation of DNA synthesis and complement-fixing antigen production in human diploid cell cultures with SV40: evidence for abortive infection (in preparation).
Sheinin, L.: Studies on the thymidine kinase activity of mouse embryo cells infected with polyoma virus. Virology 28:47, 1966.
Winocour, E.: Attempts to detect an integrated polyoma genome by nucleic acid hybridization. I. “Reconstruction” experiments and complementarity tests between synthetic polyoma RNA and polyoma tumor DNA. Virology 25:276–288, 1965.
Winocour, E.: Attempts to detect an integrated polyoma genome by nucleic acid hybridization. II. Complementarity between polyoma virus DNA and normal mouse synthetic RNA. Virology 27:520–527, 1965.
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Defendi, V. (1966). Discussion. In: Kirsten, W.H. (eds) Malignant Transformation by Viruses. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87402-4_10
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DOI: https://doi.org/10.1007/978-3-642-87402-4_10
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