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Lipoproteins

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Book cover Lipids and Lipidoses

Abstract

Early investigators interested in lipid extraction and protein isolation recognized that protein-lipid complexes exist in plasma. Protein-lipid complexes were discussed in the classical extraction studies of Schulz (1897), Nerking (1901), and Shimidzu (1910). Protein chemists such as Hardy (1905), Haslam (1913), Chick (1914), and Bang (1918) accumulated considerable data on protein-lipid complexes. Subsequent investigators were more concerned with the properties of pure lipids and pure proteins than with the properties of heterogeneous protein-lipid complexes which were difficult to distinguish from isolation artifacts. Only a few significant studies were published in the decades between 1920 and 1940. A notable series of experiments on the isolation of pure lipoproteins was begun by Macheboeuf in 1929 (Macheboeuf and Rebeyrotte 1949). These studies demonstrated the feasibility of lipoprotein purification ; however, biochemical techniques were not adequate for rigorous investigations of complex macromolecules such as lipoproteins.

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Cornwell, D.G. (1967). Lipoproteins. In: Schettler, G. (eds) Lipids and Lipidoses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87367-6_6

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