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Allgemeine biochemische Wirkungen der Glukokortikoide auf Zellen und Gewebe

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Kortikosteroide in der Augenheilkunde

Part of the book series: Symposien der Deutschen Ophthalmologischen Gesellschaft ((OPH.GES.))

Zusammenfassung

Die ersten Kenntnisse über die biochemischen Wirkungen der Glukokortikoide verdanken wir dem Studium der Ausfallerscheinungen nach einer Zerstörung der Nebennierenrinden. An dem klinischen Bild des Morbus Addison und nach der experimentellen Adrenalektomie kann man die heute in vielen physiologisch-chemischen Details bekannten Wirkungen der Nebennierenrindenhormone beobachten. Als wesentliche Symptome zeigen sich nach dem Entzug der Glukokortikoide eine Hypoglykämie und eine Verminderung der Glykogenvorräte des Körpers. (Baker, 1951; Britton, 1930; Britton und Silvette, 1934; Porges, 1909.)

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Literatur

  • Abraham, A. D., Sekeris, C. E.: Inhibitory action of steroid hormones on RNA synthesis of isolated thymus nuclei. Biochim. Biophys. Acta 247, 562 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Allison, A. C., Davies, P.: The control of lysosomal enzyme synthesis and effects of steroids. In: Effects of Drugs on Cellular Control Mechanisms. Ed. by B. R. Rabin, R. B. Freedman, p. 49–67. Macmillan 1971.

    Google Scholar 

  • Allison, A. C., Mallucci, L.: Lysosomes in dividing cells with special reference to lymphocytes. Lancet 2, 1371 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Apponi Battini, G.: Über den Glucose-und Glykoproteingehalt im Kammerwasser, im Glaskörper und in der Linse der Kaninchen nach Behandlung mit Glykokortikoiden. Klin. Mbl. Augenheilk. 152, 709 (1968).

    Google Scholar 

  • Aquavella, J. V., Gasset, A. R., Dohlman, C. H.: Corticosteroids in corneal wound healing. Amer. J. Ophthalm. 58, 621 (1964).

    CAS  Google Scholar 

  • Ashmore, J., Hastings, A. B., Nesbett, F. B., Renold, A. E.: Studies on carbohydrate metabolism in rat liver slices. VI. Hormonal factors influencing glucose-6-phosphatase. J. biol. Chem. 218, 77 (1956).

    PubMed  CAS  Google Scholar 

  • Baker, B. L.: Comparison of histological changes induced by experimental hyperadrenocorticalism and inanition. Recent Progr. Hormone Res. 7, 331 (1951).

    Google Scholar 

  • Britton, S.: Adrenal insufficiency and related considerations. Physiol. Rev. 10, 617 (1930).

    Google Scholar 

  • Britton, S. W., Silvette, H.: On the function of the adrenal cortex-general carbohydrate and circulatory theories. Amer. J. Physiol. 107, 190 (1934).

    CAS  Google Scholar 

  • Buddecke, E.: Grundriß der Biochemie. Für Studierende der Medizin, Zahnmedizin und Naturwissenschaften. 2. Aufl. Berlin: de Gruyter 1971.

    Google Scholar 

  • Clark, I.: Effect of cortisone on protein metabolism in the rat as studied with isotopic glycine. Fed. Proc. 9, 161 (1950).

    Google Scholar 

  • Daughaday, W. H., Mariz, I. K.: The formation of free hydroxyproline by rat cartilage in vitro. J. biol. Chem. 237, 2831 (1962).

    PubMed  CAS  Google Scholar 

  • DeBodo, R. C., Altszuler, N.: Insulin hypersensitivity and physiological insulin antagonists. Physiol. Rev. 38, 389 (1958).

    CAS  Google Scholar 

  • Dorfman, A., Schiller, S.: Effects of hormones on the metabolism of acid mucopolysaccharides of connective tissue. Recent Progr. Hormone Res. 14, 427 (1958).

    CAS  Google Scholar 

  • Engel, F. L.: Roles of the adrenal cortex and stress in the regulation of protein metabolism. Recent Progr. Hormone Res. 6, 277 (1951).

    Google Scholar 

  • Exton, J. H., Park, C. R.: Control of gluconeogenesis in the perfused liver of normal and adrenalectomized rats. J. biol. Chem. 240, 955 (1965).

    PubMed  CAS  Google Scholar 

  • Garran, L. B., Howell, R. R.: The role of messenger RNA in mammalian enzyme induction. Fed. Proc. 22, 524 (1963) (Abstract).

    Google Scholar 

  • Gasset, A. R., Lorenzetti, D. W. C., Ellison, E. M., Kaufman, H. E.: Quantitative corticosteroid effect on corneal wound healing. Arch. Ophthal. 81, 589 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, L., Knox, W. E., Behrman, E. J.: Studies on the nature, inducibility and assay of the threonine and serine dehydrase activities of rat liver. J. biol. Chem. 237, 2855 (1962a).

    PubMed  CAS  Google Scholar 

  • Goldstein, L., Stella, E. J., Knox, W. E.: The effect of hydrocortisone on tyrosine-ketoglutarate transaminase and tryptophan pyrrolase activities in the isolated, perfused rat liver. J. biol. Chem. 237, 1723 (1962b).

    PubMed  CAS  Google Scholar 

  • Henning, H. V., Seiffert, I., Seubert, W.: Cortisol induzierter Anstieg der Pyruvatcarboxylaseaktivität in der Rattenleber. Biochim. biophys. Acta (Amst.) 77, 345 (1963).

    Article  CAS  Google Scholar 

  • Hirschhorn, R., Kaplan, J. M., Goldberg, A. F., Hirschhorn, K., Weissmann, G.: Acid phosphatase rich granules in human lymphocytes induced by photohaemagglutinin. Science 147, 55 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Hohorst, H. J., Kreutz, F. H., Reim, M., Hübener, H. J.: The oxidation/reduction state of the extramitochondrial DPN/DPNH system in rat liver and the hormonal control of substrate levels in vivo. Biochem. and Biophysic. Res. Comm. 4, 163 (1961).

    CAS  Google Scholar 

  • Ilyin, V. S.: Hormonal regulation of liver hexokinase activity. Advanc. Enzym. Reg. 2, 151 (1964).

    Article  CAS  Google Scholar 

  • Jacob, F., Monod, J.: Genetic regulatory mechanism in the synthesis of proteins, J. Molec. Biol. 3, 318 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Janoski, A. H., Shaver, J. C., Christy, N. P., Rosner, W.: On the pharmacological actions of 21-carbon hormonal steroids (“Glucocorticoids”) of the adrenal cortex in mammals. In: Hdb. Exp. Pharm. XIV. Bd. TI. 3. S. 256–424. Hrsg. O. Eichler, Berlin: Springer 1968.

    Google Scholar 

  • Kay, J. E., Cooper, H. L.: Rapidly labeled cytoplasmatic RNA in normal and phytohaemagglutinin stimulated human lymphocytes. Biochim. biophys. Acta 186, 62 (1969).

    CAS  Google Scholar 

  • Kendall, E. C.: Hormones of the adrenal cortes. Endocrinology 30, 853 (1942).

    Article  CAS  Google Scholar 

  • Kirsten, E., Kirsten, H. J., Hohorst, H. J., Bücher, Th.: Free amino acids in alloxan diabetic rat livers. Biochem. and Biophys. Res. Comm. 4, 169 (1961).

    CAS  Google Scholar 

  • Knox, W. E., Auerbach, V. H.: The hormonal control of tryptophan perixodase in the rat. J. biol. Chem. 214, 307 (1955).

    PubMed  CAS  Google Scholar 

  • Langdon, R. G., Wekley, D. R.: The influence of hormonal factors and of diet upon hepatic glucose-6-phosphatase activity. J. Biol. Chem. 214, 167 (1955).

    PubMed  CAS  Google Scholar 

  • Lardy, H. A., Foster, D. O., Shrago, E., Ray, P. D.: Metabolic and hormonal regulation of phosphoendpyruvate synthesis. Advanc. Enzym. Reg. 2, 39 (1964).

    Article  CAS  Google Scholar 

  • Larsen, G.: Connective tissue of the cornea and vitreous body and the hormonal influence. In: Hormones and Conn. Tissues. Ed. G. Asboe-Hansen. Willes and Wilk Comp. 1966.

    Google Scholar 

  • Levine, R., Goldstein, M. S.: Glucocorticoid action of adrenocortical hormones. In: Hdb. Exp. Pharm. XIV. Bd. TI. 2. S. 3–10. Hrsg. H. Wendler-Deane, B. L. Rubin. Berlin: Springer 1964.

    Google Scholar 

  • Likar, L. J., Mason, M. M., Rosenkrantz, H.: Response of the level of acid mucopolysaccharides in rat granulation tissue to cortisol. Endocrinology 72, 393 ( 1963.

    Article  PubMed  CAS  Google Scholar 

  • Lin, E. C. C., Knox, W. E.: Adaptation of the rat liver tyrosine-ketoglutarate transaminase. Biochim. biophys. Acta (Amst.) 26, 85 (1957).

    Article  CAS  Google Scholar 

  • Loeb, L. A., Ewald, J. L., Agarwal, S. S.: Zitiert in Allison und Davies (1971). Cancer Res. 30, 2514 (1970).

    PubMed  CAS  Google Scholar 

  • Long, C. N. H.: A discussion of the mechanism of action of adrenal cortical hormones on carbohydrate and protein metabolism. Endocrinology 30, 870 (1942).

    Article  CAS  Google Scholar 

  • Long, C. N. H., Katzin, B., Fry, E. G.: The adrenal cortex and carbohydrate metabolism. Endocrinology 26, 309 (1940).

    Article  CAS  Google Scholar 

  • Nordlie, R. C., Lardy, H. A.: Mammalian liver phosphoenolpyruvate carboxykinase activities. J. biol. Chem. 238, 2259 (1963).

    PubMed  CAS  Google Scholar 

  • Nowell, P. C.: Inhibition of human leukocyte mitosis by prednisolone in vitro. Cancer Res. 21, 1518 (1961).

    PubMed  CAS  Google Scholar 

  • Pitot, H. C., Potter, V. R., Morris, H. P.: Metabolic adaptations in rat hepatomas. 1. The effect of dietary protein on some inducible enzymes in liver and hepatoma 5123. Cancer Res. 21, 1001 (1961).

    PubMed  CAS  Google Scholar 

  • Polak, F. M., Rosen, P. N.: Topical steroids and tritiated thymidine uptake (Effect of corneal wound healing). Arch. Ophthal. 77, 400 (1967).

    Article  Google Scholar 

  • Porges, O.: Hypoglykämie bei Morbus Addisonii sowie bei nebennierenlosen Hunden. Z. Klin. Med. 69, 341 (1909).

    Google Scholar 

  • Ray, P. D., Foster, D. O., Lardy, H. A.: Gluconeogenesis stimulated by hydrocortisone independently of “de novo” synthesis of enzymes. Fed. Proc. 23, 482 (1964b) (Abstract).

    Google Scholar 

  • Ray, P. D., Foster, D. O., Lardy, H. A.: Mode of action of glucocorticoids. I. Stimulation of gluconeogenesis independent of synthesis de nova of enzymes. J. biol. Chem. 239, 3396 (1964a).

    CAS  Google Scholar 

  • Reif-Lehrer, L.: Glutamine synthetase activity in human retinal tissue. Arch. Ophthal. 86, 72 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Reim, M.: Warum ist die Cornea durchsichtig? 71. Ber. dtsch. Ophth. Ges. München: J. F. Bergmann 1972.

    Google Scholar 

  • Reshef, L., Shapiro, B.: Effect of epinephrine, cortisone and growth hormone on release of unesterified fatty acids by adipose tissue in vitro. Metabolism 9, 551 (1960).

    PubMed  CAS  Google Scholar 

  • Rosen, F., Nichol, C. A.: Studies on the nature and specifity of the induction of several adaptive enzymes responsive to cortisol. Advanc. Enz. Reg. 2, 115 (1964).

    Article  CAS  Google Scholar 

  • Rosen, F., Roberts, N. R., Nichol, C. A.: Glucocorticosteroids and transaminase activity. I. Increased activity of glutamic-pyruvic transaminase in four conditions associated with gluconeogenesis. J. biol. Chem. 234, 476 (1959 b).

    Google Scholar 

  • Scarpelli, D. G., Knouff, R. A., Angerer, C. A.: Cortisone on oxygen consumption of granulation tissue from the rabbits. Proc. Soc. exp. Biol. 84, 94 (1953).

    PubMed  CAS  Google Scholar 

  • Segal, H. L., Rosso, R. G., Hopper, S., Weber, M. M.: Direct evidence for an increase in enzyme level as the basis for the glucocorticoid-induced increase in glutamic-alanine transaminase activity in rat liver. J. Biol. Chem. 237, PC 3303 (1962b).

    Google Scholar 

  • Sekeris, C. E.: Wirkung der Hormone auf den Zellkern. In: Wirkungsmechanismus der Hormone. Bearb. v. P. Karlson. S. 126–157. Berlin: Springer 1967.

    Chapter  Google Scholar 

  • Seubert, W.: Cortisol als Enzyminduktor mit besonderer Berücksichtigung der Gluconeogenese. In: Wirkungsmechanismus der Hormone. Bearb. von P. Karlson. S. 158–196. Berlin: Springer 1967.

    Chapter  Google Scholar 

  • Sharma, R. G., Manjeshwar, Weinhouse, S.: Hormonal and dietary regulation of hepatic glucokinase. Advanc. Enzym. Reg. 2, 189 (1964).

    Article  CAS  Google Scholar 

  • Smelser, G. K., Ozanics, V.: Relation of steroid hormones to the development of experimental exophthalmus. Amer. J. Ophthal. 34, 87 (1951).

    PubMed  CAS  Google Scholar 

  • Sobel, H., Gabay, S., Johnson, C.: Effect of cortisone on connective tissues of the rat. Proc. Soc. exp. Biol. (N.Y.) 99, 296 (1958).

    CAS  Google Scholar 

  • Sobel, H., Gabay, S., Johnson, C., Hassan, B.: Carcass nitrogen and the hexosamine collagen ratio of skin following starvation and cortisone administration in rats and guinea pigs. Metabolism 8, 180 (1959).

    PubMed  CAS  Google Scholar 

  • Sobel, H., Marmorston, J.: The effect of cortisone on the collagen and hexosamine content of the skin and femurs of one year old rats. Endocrinology 55, 21 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Sobel, H., Marmorston, J.: Hormonal influences upon connective tissue changes of aging. Recent Progr. Hormone Res. 14, 457 (1958).

    CAS  Google Scholar 

  • Sols, A., Salas, M., Vinuela, Eladio: Induced by insulin biosynthesis of liver gluco- kinase. Advanc. Enzym. Reg. 2, 177 (1964).

    Article  CAS  Google Scholar 

  • Sorensen, B. M.: Influence of glucocorticoid and anabolic steroid hormones on the wound healing process. In: Hormones and Conn. Tissue. Ed. G. Asboe-Hansen. S. 106–123. Kopenhagen: Munksgaard 1966.

    Google Scholar 

  • Sûcié, M., Kovacié, N.: Resultate der Behandlung des malignen endokrinen Exophthalmus mit Cortison. Minch. med. Wschr. 102, 282 (1960).

    Google Scholar 

  • Weber, C., Allard, C., Lamirande, G. de, Cantero, A.: Liver glucose6-phosphatase activity and intracellular distribution after cortisone administration. Endocrinology 58, 40 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Weber, C., Cantero, A.: Glucose-6-phosphatase studies in fasting. Science 120, 851 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Weber, C., Cantero, A.: Studies on hormonal factors influencing hepatic glucose-6-phosphatase. Endocrinology 61, 701 (1957 b).

    Google Scholar 

  • Weber, C., Krivastava, S. K., Singhal, R. L.: Role of enzymes in homeostasis. VII. Early effects of corticosteroid hormones on hepatic gluconeogenic enzymes, ribonucleic acid metabolism and amino acid level. J. biol. Chem. 240, 750 (1965c).

    PubMed  CAS  Google Scholar 

  • Weber, C., Singhal, R. L., Stamm, N. B., Fisher, E. A., Mentendiek, M. A.: Regulation of enzymes involved in gluconeogenesis. Advanc. Enzym. Reg. 2, 1 (1964).

    Article  CAS  Google Scholar 

  • Weber, C., Singhal, R. L.: Role of enzymes in homeostasis. V. Actinomycin and puromycin inhibition of cortisone-induced synthesis of hepatic glucose-6-phosphatase and fructose-1,6-diphosphatase. J. biol. Chem. 239, 521 (1964 a).

    Google Scholar 

  • Weissmann, G., Fell, H. B.: The effect of hydrocortisone on the response of fetal rat skin culture to ultraviolett irradiation. J. exp. Med. 116, 365 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Weissmann, G., Thomas, L.: Studies on lysosomes: The effect of Endotoxin, Endotoxin tolerance and cortisone on the release of acid hydrolases from a granular fraction of rabbit liver. J. exp. Med. 116, 433 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Wood, Don C., Contaxis, I., Sweet, D., Smith II, J. C., Dolah, J. van: Response of rabbits to corticosteroids. I. Influence on growth, intraocular pressure and lens transparency. Am. J. Ophthal. 63, 841 (1967).

    CAS  Google Scholar 

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Reim, M. (1973). Allgemeine biochemische Wirkungen der Glukokortikoide auf Zellen und Gewebe. In: Böke, W. (eds) Kortikosteroide in der Augenheilkunde. Symposien der Deutschen Ophthalmologischen Gesellschaft. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-87229-7_14

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  • DOI: https://doi.org/10.1007/978-3-642-87229-7_14

  • Publisher Name: J.F. Bergmann-Verlag, Munich

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