The observation by Barkan in 1927 (2) that serum iron was non-dialyzable at physiological pH marked the beginning of a trail of chemical and physiological research which led to the crystallization in 1952 (14) of transferrin, a serum protein with the specific properties of binding and transporting iron. In the last decade, the physiological aspects of iron transport have been greatly illuminated by the work of several investigators, but problems still exist. In particular, such detailed studies as have been undertaken on the structure of transferrin have barely scratched the surface of this problem.
KeywordsCarbohydrate Electrophoresis Anemia Serine Proline
Unable to display preview. Download preview PDF.
- 1.Allerton, S. E.: Doctoral Thesis, Division of Medical Sciences, Harvard University, U.S.A. (1962).Google Scholar
- 7.Harris, H., D. C. PeNNington, and E. B. Robson: Biochem. J. (G.B.) 74, 44P (1960).Google Scholar
- 8.Hazen, E. E. Jr.: Doctoral Thesis, Division of Medical Sciences, Harvard University, U.S.A. (1963).Google Scholar
- 10.Jamieson, G. C.: Fed. Proc. (U.S.A.) 22, 5338 (1963).Google Scholar
- 12.Jourdian, G. W., F. Shimuzu, and S. Roseman: Fed. Proc. (U.S.A.) 20, 161 (1961).Google Scholar
- 13.Kirk, R. L., W. C. Parker, and A. G. Bearn: TO be published.Google Scholar
- 21.Parker, W. C.: Doctoral Thesis, The Rockefeller Institute, U.S.A. (1963).Google Scholar
- 23.Rosevear, J. W., and E. Smith: J. Biol. Chem. (U.S.A.) 236, 425 (1961).Google Scholar
- 24.Schtjltze, H. E., R. Schmidtberger, and H. Haupt: Biochem. J. (G.B.) 329, 490 (1958).Google Scholar
- 27.Williams, J.: Biochem. J. (G.B.) 83, 355 (1962).Google Scholar