Skip to main content

Androgens and Oestrogens

  • Chapter

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 24))

Abstract

The use of sex hormones for the treatment of breast cancer probably contributed more to the management of the advanced disease than the advent of any other therapy. Their value in patients too ill for more severe treatment, their relative lack of debilitating side effects, and the long periods of remission that may be obtained, combine to give hormones a measure of advantage over any other therapy. But it is this very simplicity of use which has resulted in a relative lack of endeavour by clinical research workers to investigate their mode of action. There is little encouragement to investigate the features which might predict those patients who may benefit from hormone therapy when it is so easy to try the drugs clinically on all cases. Androgens or oestrogens can be administered without the patient being admitted to hospital, and the response of the tumour soon provides the answer as to whether or not the treatment will work.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Braunsberg, H., Irvine, W. T., James, V. H. T.: A comparison of steroid hormone concentrations in human tissues including breast cancer. Brit. J. Cancer 21, 714 (1967).

    Article  PubMed  CAS  Google Scholar 

  • James, V. H. T.: Observations on the binding of testosterone to malignant mammary tumours and other tissues in vitro. Brit. J. Cancer 21, 703 (1967).

    Article  PubMed  Google Scholar 

  • Bulbrook, R. D., Greenwood, F. C., Hayward, J. L.: Selection of breast cancer patients for adrenalectomy or hypophysectomy by determination of urinary 17-hydroxy corticosteroids and aetiocholanolone. Lancet 1960 I, 1154.

    Google Scholar 

  • Hayward, J. L.: The possibility of predicting the response of patients with early breast cancer to subsequent endocrine ablation. Cancer Res. 25, 1135 (1965).

    PubMed  Google Scholar 

  • Spicer, C. C., Thomas, B. S.: Abnormal excretion of urinary steroids by women with early breast cancer. Lancet 1962 a I I, 1238.

    Google Scholar 

  • Spicer, C. C., Thomas, B. S.: A comparison between the urinary steroid excretion of normal women and women with advanced breast cancer. Lancet 1962 b I I, 1235.

    Google Scholar 

  • Thomas, B. S.: The relation between the urinary 17-hydroxy corticosteroids and 11-deoxy-17-oxosteroids and the fate of patients after mastectomy. Lancet 1964 I, 945.

    Google Scholar 

  • Cantino, I. J., Gordan, G. S.: High dosage d 1 testolactone therapy of disseminated car-cinoma of the breast. Cancer 20, 458 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Chakmakjian, Z. H., Bethune, J. E.: Sodium sulfate treatment of hypercalcemia. New Engl. J. Med. 275, 862 (1966).

    CAS  Google Scholar 

  • Co-operative Breast Cancer Group: Results of studies of the Co-operative Breast Cancer Group 1961–1963. Cancer Chemother. Rep. 41, Suppl. 1 (1964 a).

    Google Scholar 

  • Co-operative Breast Cancer Group: Testosterone Propionate Therapy in Breast Cancer. J. Amer. med. Ass. 188, 1069 (1964 b).

    Google Scholar 

  • Council on Drugs, Subcommittee on Breast and Genital Cancer, Committee on Research, American Medical Association: Androgens and Oestrogens in the treatment of disseminated mammary carcinoma; retrospective study of 944 patients. J. Amer. med. Ass. 172, 1271 (1960).

    Google Scholar 

  • Council on Pharmacy and Chemistry. Current status of hormone therapy of advanced mammary cancer. J. Amer. med. Ass. 146, 471 (1951).

    Google Scholar 

  • Crowley, L. G., Demetriou, J., Macdonald, I., Kotin, P., Kushinsky, S., Donovan, A. J.

    Google Scholar 

  • Levels of exogenous oestrogens in tissues in human mammary carcinoma. Surg. Forum 13, 103 (1962).

    Google Scholar 

  • Cutler, M., Schlemenson, M.: Treatment of advanced mammary cancer with testosterone. J. Amer. med. Ass. 138, 187 (1948).

    Article  CAS  Google Scholar 

  • Cutler, S. J.: In: Clinical Evaluation in Breast Cancer. Eds.: J. L. Haywardand R. D. Bulbrook. London-New York: Academic Press 1966, p. 214.

    Google Scholar 

  • DE Hertogh, R., Pearlman, W. H.: Metabolism and Localisation of Estrone-6,7-H3 in Breast Cancer. Fed. Proc. 23, 276 (1964).

    Google Scholar 

  • Deshpande, N., Bulbrook, R. D., Belzer, F. O.: Comparison between uptake of radioactivity by normal and neoplastic human breast tissue after single injection and intravenous infusion of tritiated testosterone. J. Endocr. 34, 125 (1966 a).

    Google Scholar 

  • Deshpande, N., Bulbrook, R. D., Belzer, F. O.: An apparent selective accumulation of progesterone by the human breast. Excerpta Medica Internat. Congress. Series No. 132, 750 (1966 b).

    Google Scholar 

  • Jensen, V., Bulbrook, R. D.: Accumulation of triated oestradiol by human breast tissue. Steroids 10, 219 (1967).

    Article  PubMed  Google Scholar 

  • Donovan, A. J., Bethune, J. E., Berne, T. V.: Hypercalcaemia in patients with advanced mammary cancer and osseous metastases. Effect of hormone therapy and schedule of treatment. Amer. Surg. 32, 673 (1966).

    CAS  Google Scholar 

  • Douglas, M.: The treatment of advanced breast cancer by hormone therapy. Brit. J. Cancer 6, 32 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Ellis, F., Parker, J. R., Bulbrook, R. D., Deshpande, N.: The uptake of radioactivity by normal and neoplastic human breast tissues after administration of tritiated testosterone. Brit. J. Surg. 52, 54 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Emerson, W. J., Kennedy, B. J., Graham, J. N., Nathanson, I. T.: Pathology of primary and recurrent carcinoma of the human breast after administration of steroid hormones. Cancer 6, 641 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Farrow, J. H., Woodard, H. Q.: The influence of Androgenic and Estrogenic substances on serum calcium. J. Amer. med. Ass. 118, 339 (1942).

    Article  CAS  Google Scholar 

  • Folca, P. J., Glascock, R. F., Irvine, W. T.: Studies with tritium labelled hexoestrol in advanced breast cancer. Lancet 1961 II, 796.

    Google Scholar 

  • Foss, G. L.: Palliative hormone therapy of advanced mammary cancer. Lancet 1956 I, 651. GALTON, D. A. G.: Androgen therapy in 70 cases of advanced mammary carcinoma. Brit. J. Cancer 4, 20 (1950).

    Google Scholar 

  • Goldenberg, I. S.: Testosterone propionate therapy in breast cancer. J. Amer. med. Ass. 188, 1069 (1964).

    Article  CAS  Google Scholar 

  • Bailar, J. C., Lowry, R.: Survival of women with hormonally treated breast cancer. Surg. Gynec. Obstet. 119, 785 (1964).

    PubMed  Google Scholar 

  • Gordan, G. S.: Hormonal effects of nonendocrine tumors with special reference to the hypercalcemia of breast cancer. In: Current Concepts in Breast Cancer. Eds.: A. Segaloff, K. K. Meyers, and S. Debakey. Baltimore: Williams and Wilkins 1967, p. 132.

    Google Scholar 

  • Cantino, R. J., Erhardt, L., Hansen, J., Lubich, W.: Osteolytic sterol in human breast cancer. Science 151, 1226 (1966).

    Article  PubMed  Google Scholar 

  • Gowing, N. F. C.: Histological changes in response to therapy. In: Clinical Evaluation in Breast Cancer. Eds.: J. L. Haywardand R. D. Bulbrook. LONDON-NEW York: Academic Press 1966, p. 53.

    Google Scholar 

  • Hayward, J. L.: An evaluation of some factors affecting oestrogen response in the treatment of advanced cancer of the breast. Guy’s Hosp. Rep. 106, 254 (1957).

    CAS  Google Scholar 

  • Hayward, J. L.: Assessment of response to treatment at Guy’s Hospital Breast Clinic. The estimation of the Mean Clinical Value. In: Clinical Evaluation in Breast Cancer. Eds.: J. L. HAYWARD and R. D. BULBROOK. London-New York: Academic Press 1966, pp. 131, 285.

    Google Scholar 

  • Bulbrook, R. D.: Urinary steroids and prognosis in breast cancer. In: Prognostic Factors in Breast Cancer. Eds.: A. P. M. Forrest and P. B. Kunkler. Edinburgh-London: Livingstone 1968, p. 383.

    Google Scholar 

  • Jensen, E. V., Jacobson, H. I.: Basic guides to the mechanism of estrogen action. Recent Progr. Hormone Res. 18, 387 (1962).

    CAS  Google Scholar 

  • Kennedy, B. J.: Diethylstilbestrol versus testosterone therapy in advanced breast cancer. Surg. Gynec. Obstet. 120, 1246 (1965).

    PubMed  CAS  Google Scholar 

  • Kennedy, B. J.: Hormone therapy for advanced breast cancer. Cancer 18, 1551 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, B. J.: Brown, J. H.: Combined estrogenic and androgenic hormone therapy in advanced breast cancer. Cancer 18, 431 (1965).

    Google Scholar 

  • King, R. J., Cowan, D. M., Inman, D. R.: The uptake of (6.7–3-H) oestradiol by dimethylbenzathracene-induced rat mammary tumours.

    Google Scholar 

  • Koller, P. C.: Influences of synthetic oestrogens upon advanced malignant disease. Addendum to A. Haddow, J. M. Watkinson, and E. Paterson. Brit. med. J. 1944 II, 393. Lewison, E. L., TRIMBLE, F. H.: Advanced mammary carcinoma, treated with sex hormones.

    Google Scholar 

  • J. Amer. med. Ass. 162, 1429 (1956).

    Google Scholar 

  • Meakin, J. W.: Personal Communication (1967).

    Google Scholar 

  • Allt, W. E. C., Beale, F. A., Brown, T. C., Bulbrook, R. D., Clark, R. M., Fitz-Patrick, P. J., HawkinsN. V., Hayward, J. L., Jenkins, R. D. T.: A preliminary report of two studies of adjuvant treatment of primary breast cancer. In: Prognostic Factors in Breast Cancer. Eds.: A. P. M. FORREST and P. B. KUNKLER. Edinburgh-London: Livingstone 1968, p. 157.

    Google Scholar 

  • Munson, P. L., Tashjian, A. H., Levine, L.: Evidence for parathyroid hormone in non-parathyroid tumours associated with hypercalcemia. Cancer Res. 25, 1062 (1965).

    Google Scholar 

  • Nathanson, I. T.: Hormones in relation to tumours of the female. Prog. Gynaecology 2, 218 (1950).

    Google Scholar 

  • Prudente, A.: Postoperative prophyllaxis of recurrent mammary cancer with testosterone propionate. Surg. Gynec. Obstet. 80, 575 (1945).

    Google Scholar 

  • Quincey, R. V., Gray, C. H.: Uptake of (1,2–3H) 17a Methyltestosterone by breast carcinoma and other tissues of human subjects. Brit. J. Cancer 20, 271 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Segaloff, A.: Assessment of response to treatment by the Co-operative Breast Cancer Group. In: Clinical Evaluation in Breast Cancer. Eds.: J. L. HAYWARD and R. D. BULBROOK. London-New York: Academic Press 1966, pp. 125, 275.

    Google Scholar 

  • Segaloff, A.: Hormones and breast cancer. Recent Progr. Hormone Res. 22, 351 (1966).

    CAS  Google Scholar 

  • Horwitt, B. N., Carabisi, R. A., Murison, P. J., Schlosser, J. V.: Hormonal therapy in cancer of the breast. V. The effect of methyltestosterone on clinical course and hormonal excretion. Cancer 6, 483 (1953).

    Google Scholar 

  • Segaloff, A.: Weeth, J. B., Meyer, K. K., Rongone, E. L., Cunningham, M. E. G.: Hormonal therapy in cancer of the breast. XIX. Effect of oral administration of d1 testololactone on clinical course and hormone excretion. Cancer 15, 633 (1962).

    Google Scholar 

  • Segaloff, A.: Rongone, E. L., Murison, P. J., Bowers, C. Y.: Hormonal therapy in cancer of the breast. XVI. The effect of dl testololactone on clinical course and hormonal excretion. Cancer 13, 10–17 (1960).

    Google Scholar 

  • Sherwood, L. M., O’riordan, J. L., Aurbach, G. D.: Production of parathyroid hormone by nonparathyroid tumors. J. clin. Endocr. 27, 140 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Thalassinos, N., Joflin, G. F.: Phosphate treatment of hypercalcaemia due to carcinoma. Brit. med. J. 1968 II, 14.

    Google Scholar 

  • Virchow, R.: Virchows Arch. path. Anat. 8, 103 (1855).

    Google Scholar 

  • Wali’ole, A. L., Paterson, E.: Synthetic oestrogens in mammary cancer. Lancet 1949 II, 783.

    Google Scholar 

  • Walser, M., browder, A. A.: Ion association III: The Effect of sulfate infusion on calcium excretion. J. clin. Invest. 38, 1404 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Wolff, B.: The differential cell count in cancer of the breast and response to hormone therapy. Guy’s Hosp. Rep. 106, 53 (1957).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1970 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Hayward, J. (1970). Androgens and Oestrogens. In: Hormones and Human Breast Cancer. Recent Results in Cancer Research, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87015-6_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-87015-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87017-0

  • Online ISBN: 978-3-642-87015-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics