Skip to main content
SpringerLink
Log in

Die Beeinflussung der körperlichen Leistungsfähigkeit durch Antihypertensiva

  • Chapter
Hochdruck und Sport

  • 21 Accesses

Zusammenfassung

Eine eventuelle Beeinflussung der Leistungsfähigkeit durch blutdrucksenkende Medikamente ist von wesentlicher praktischer Bedeutung, da einerseits viele Hypertoniker noch jung sind und andererseits zahlreiche Hypertoniker ein regelmäßiges körperliches Training durchführen. Je geringer ein Antihypertensivum die körperliche Leistungsfähigkeit beeinflußt, um so besser wird die Patientencompliance sein. Blutdrucksenkende Medikamente, die beim körperlich aktiven Hypertoniker eingesetzt werden, müssen auch den Belastungsblutdruck ausreichend senken. Diese Forderung erfüllen in erster Linie Beta-Rezeptorenblocker und Calcium-Antagonisten, so daß diese Pharmaka im folgenden etwas auführlicher abgehandelt werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Aigner A, Muß N, Krempler F, Fenninger H, Sandhofer F (1983) Einfluß einer akuten Beta1und Beta1/2-Rezeptoren-Blockade auf den Kohlenhydrat- und Fettstoffwechsel unter Belastungsbedingungen. Dtsch med Wschr 108: 293–298

    Article  PubMed  CAS  Google Scholar 

  2. Andersson K-E (1978) Effects of calcium and calcium-antagonists on the excitation-contraction coupling in striated and smooth muscle. Acta Pharmacol Toxicol Suppl 1: 5–14

    Google Scholar 

  3. Boyar RM, Fixler DF, Kaplan NM (1980) Effects of clonidine on 24 hour hormonal secretory patterns, cardiovascular hemodynamics, and central nervous function in hypertensive adolescents. Hypertension 2: 83

    Article  PubMed  CAS  Google Scholar 

  4. Brewer C (1972) Beneficial effects of beta-adrenergic blockade on “exam nerves”. Lancet II: 814–815

    Google Scholar 

  5. Carlsson E, Fellenius E, Lundberg P, Svensson L (1978) Beta-adrenoceptor blockers, plasmapotassium and exercise. Lancet II: 424–425

    Article  Google Scholar 

  6. Corea L, Miele N, Bentivoglio M, Boschetti E, Agabiti-Rosei E, Muisean G (1979) Acute and chronic effects of nifedipine on plasma renin activity and plasma adrenaline and noradrenaline in controls and hypertensive patients. Clin Sci 57: 115–117

    Google Scholar 

  7. Day IL (1975) The metabolic consequences of adrenergic blockade, a review. Metabolism 24: 987–996

    Article  PubMed  CAS  Google Scholar 

  8. Duffey DJ, Horwitz LD, Brammel HL (1984) Nifedipine and the conditioning response. Am J Cardiol 53: 908–911

    Article  PubMed  CAS  Google Scholar 

  9. Ekblom B, Goldberg AN, Kilbom A, Astrand PO (1972) Effect of atropine and propranolol on the oxygen transport system during exercise in man. Scand J Clin Lab Invest 30: 35–43

    Article  PubMed  CAS  Google Scholar 

  10. Fagard R, Lijnen P, Amery A (1982) Hemodynamic response to captopril at rest and during exercise in hypertensive patients. Am J Cardiol 49: 1569–1571

    Article  PubMed  CAS  Google Scholar 

  11. Fagard R, Lijnen P, Vanhees L, Amery A (1982) Hemodynamic response to converting enzyme inhibition at rest and exercise in humans. J Appl Physiol 53: 576–581

    Article  PubMed  CAS  Google Scholar 

  12. Falkner B, Lowenthal DT, Onesti G (1980) Dynamic exercise response in hypertensive adolescent on clonidine therapy: Clonidine therapy in adolescent hypertension. Pediatr Pharmacol 1: 121–128

    CAS  Google Scholar 

  13. Fellenius E (1983) Muscle fatigue and beta-blockers-a review. Int J Sports Med 4: 1–8

    Article  PubMed  CAS  Google Scholar 

  14. Ferguson RK, Vlasses PH, Koffer H, Clementi RA, Koplin JR, Willcox CM (1983) Effect of captopril and propranolol, alone and in combination, on the responses to isometric and dynamic exercise in normotensive and hypertensive men. Pharmacother 3: 125–130

    CAS  Google Scholar 

  15. Folgering A, van Bussel M (1980) Maximal exercise power after a single dose of metroprolol and of slow-release metoprolol. Eur J Clin Pharmacol 18: 225–229

    Article  PubMed  CAS  Google Scholar 

  16. Franz IW, Lohmann W (1979) Der Einfluß einer chronischen sog. kardioselektiven und nichtkardioselektiven Beta-Rezeptoren-Blockade auf den Blutdruck, die Sauerstoffaufnahme und den Kohlenhydratstoffwechsel. Z Kardiol 68: 503–509

    PubMed  CAS  Google Scholar 

  17. Franz IW, Lohmann W, Koch G, Quabbe HJ (1983) Aspects of hormonal regulation of lipolysis during exercise: effects of chronic betareceptor blockade. Int J Sports Med 4: 14–20

    Article  PubMed  CAS  Google Scholar 

  18. Franz IW, Wiewel D (1985) Antihypertensive Wirkung von Nitrendipin, Nifedipin und Acebutolol und deren Kombination auf den Ruhe- und Belastungsblutdruck bei Hochdruckkranken. Z Kardiol 74: 111–116

    PubMed  CAS  Google Scholar 

  19. Frisk-Holmberg M, Jorfeld L, Juhlin-Dannfelt A, Karlsson J (1979) Metabolic changes in muscle on long term alprenolol therapy. Clin Pharmacol Ther 26: 566–571

    PubMed  CAS  Google Scholar 

  20. Frisk-Holmberg M, Jorfeld L, Juhlin-Dannfelt A (1981) Metabolic effects in muscle during antihypertensive therapy with beta1- and beta1/beta2-adrenoceptor blockers. Clin Pharmacol Ther 30: 611–618

    Article  PubMed  CAS  Google Scholar 

  21. Furberg C (1967) Adrenergic beta-blockade and physical work capacity. Acta Med Scand 182: 119–127

    Article  PubMed  CAS  Google Scholar 

  22. Galbo H, Holst JJ, Christensen NJ, Hilsted J (1976) Glucagon and plasma catecholamines during beta-receptor blockade in exercising man. J Appl Physiol 40: 855–863

    PubMed  CAS  Google Scholar 

  23. Gorski J, Pietrzyk K (1982) The effect of beta-adrenergic blockade on intramuscular glycogen mobilization during exercise in the rat. Eur J Appl Physiol 48: 201–205

    Article  CAS  Google Scholar 

  24. Gross SR, Mayer SE (1974) Regulation of phosphorylase B to A conversion in muscle. Life Sci 14: 401–414

    Article  PubMed  CAS  Google Scholar 

  25. Harms D, Pachale E, Nechvatal D (1981) Vigilanz und Beta-Blockade. Fortschr Med 99: 313–317

    PubMed  CAS  Google Scholar 

  26. Harri MNE (1979) Physical training under the influence of beta-blockade in rats. II. Effects on vascular reactivity. Eur J Appl Physiol 42: 151–157

    Article  CAS  Google Scholar 

  27. Harri MNE, Narvola I (1979) Physical training under the influence of beta-blockade in rats : Effect on adrenergic responses. Eur J Appl Physiol 41: 199–210

    Article  CAS  Google Scholar 

  28. Henriksson J, Svedenhag J, Richter EA, Galbo H (1979) Significance of the sympatho-adrenal system for the exercise-induced enzymatic adaptation of skeletal muscle. Acta Physiol Scand 105: 38A

    Google Scholar 

  29. Juhlin-Dannfelt AC, Terblanche SE, Fell RD, Young JC, Holloszy JO (1982) Effects of β-adrenergic receptor blockade on glycogenolysis during exercise. J Appl Physiol 5: 549–554

    Google Scholar 

  30. Kaiser P (1984) Physical performance and muscle metabolism during β-adrenergic blockade in man. Acta Physiol Scand Suppl 536

    Google Scholar 

  31. Karlsson J, Kjessel T, Kaiser P (1983) Alpine skiing and acute beta-blockade. Int J Sports Med 4: 190–193

    Article  PubMed  CAS  Google Scholar 

  32. Keul J, Huber G, Kindermann W, Burmeister P, Petersen KG (1976) Die Wirkung eines neuartigen Beta-Rezeptoren-Blockers (Bunitrolol) auf Kreislauf und Stoffwechsel unter extremen Streßbedingungen. Med Welt 27: 437–443

    PubMed  CAS  Google Scholar 

  33. Kindermann W, Keul J (1978) Betablocker bei hyperadrenergen Belastungen. Cardiology 63 Suppl 1: 21–25

    Article  PubMed  CAS  Google Scholar 

  34. Kindermann W, Scheerer W, Salas-Fraire O, Biro G, Wölfing A (1984) Verhalten der körperlichen Leistungsfähigkeit und des Metabolismus unter akuter Beta1- und Beta1/2-Blockade. Z Kardiol 73: 380–387

    PubMed  CAS  Google Scholar 

  35. Kindermann W, Lehrmann S, Schmitt W (1986) Einfluß einer Kombination von Nifedipin und Mefrusid auf die körperliche Leistungsfähigkeit und den Metabolismus. Münchn Med Wschr 128: 53–56

    Google Scholar 

  36. Kindermann W, Schmitt W, Stengele E (1985) Einfluß von Calcium-Antagonisten auf die körperliche Leistungsfähigkeit und den Metabolismus. Dtsch med Wschr 43: 1657–1661

    Article  Google Scholar 

  37. Kinoshita M, Motomura M, Kusukawa R, Kawakita S (1979) Comparison of hemodynamic effects between beta-blocking agents and a new antianginal agent, diltiazem hydrochloride. Jpn Circ J 43: 587–598

    Article  CAS  Google Scholar 

  38. Kopp KH, Huber G, Keul J (1978) Veränderungen von Herzfrequenz und Stoffwechselparametern im Blut beim Fallschirmspringen. Dtsch Z Sportmed 29: 44–49

    CAS  Google Scholar 

  39. Kullmer T, Kindermann W (1985) Physical performance and serum potassium under chronic beta-blockade. Eur J Appl Physiol 54: 350–354

    Article  CAS  Google Scholar 

  40. Lawlor MR, Thomas DP, Michele JJ, Carey RA, Paolone AM, Bove AA (1985) Effects of chronic β-adrenergic blockade on hemodynamic and metabolic responses to endurance training. Med Sci Sports 17: 393–400

    CAS  Google Scholar 

  41. Lee WR, Fox LM, Slotkoff LM (1979) Effects of antihypertensive therapy on cardiovascular response to exercise. Am J Cardiol 44: 325–328

    Article  PubMed  CAS  Google Scholar 

  42. Lederballe Pedersen O, Mikkelsen E, Christensen NJ, Kornerup HJ, Pedersen EB (1979) Effect of nifedipine on plasma renin, aldosterone and catecholamines in arterial hypertension. Eur J Clin Pharmacol 15: 235–240

    Article  Google Scholar 

  43. Lidén S, Gottfries CG (1974) Beta-blocking agents in the treatment of catecholamine-induced symptoms in musicians. Lancet II: 529

    Article  Google Scholar 

  44. Lohmann FW (1981) Die Beeinflussung des Stoffwechsels durch Beta-Rezeptoren-Blocker. Klin Wschr 59: 49–57

    Article  PubMed  CAS  Google Scholar 

  45. Lundborg P, Aström H, Bengtsson C, Fellenius E, von Schenk H, Svensson L, Smith U (1981) Effect of beta-blockade on exercise performance and metabolism. Clin Sci 61: 229–305

    Google Scholar 

  46. Lund-Johansen P, Omvik P (1984) Long-term hemodynamic effects of enalapril at rest and during exercise in essential hypertension. Scand J Urol Nephrol (Suppl) 79: 87–91

    CAS  Google Scholar 

  47. Manhem P, Bramnert M, Hulthen UL, Hoekfelt B (1981) The effect of captopril on catecholamines, renin activity, angiotensin II and aldosterone in plasma during physical exercise in hypertensive patients. Eur J Clin Invest 11: 389–395

    Article  PubMed  CAS  Google Scholar 

  48. Mc Leod AA, Kraus WE, Williams RS (1984) Effects of beta1-selective and nonselective betaadrenoceptor blockade during exercise conditioning in healthy adults. Am J Cardiol 53: 1656–1661

    Article  Google Scholar 

  49. Millar JA, Struthers AD (1984) Calcium antagonists and hormone release. Clin Sci 66: 249–255

    PubMed  CAS  Google Scholar 

  50. Moser B, Hilmer W (1977) Zur Beta-Sympathikolyse bei Sportschützen. Dtsch Z Sportmed 28: 352–357

    Google Scholar 

  51. Muisean G, Agabiti-Rosei E, Castellano M, Alicandri C, Corea L, Fariello R, Beschi M, Romanelli G (1982) Antihypertensive and humoral effects of verapamil and nifedipine in essential hypertension. J Cardiovasc Pharmacol 4 (Suppl 3): 325–329

    Article  Google Scholar 

  52. Nylander E (1985) Training-induced bradycardia in rats on cardioselective and non-selective beta receptor blockade. Acta Physiol Scand 123: 147–149

    Article  PubMed  CAS  Google Scholar 

  53. Obina R, Wilson R, Goebel M, Campbell D (1979) Effect of conditioning programm on patients taking propranolol for angina pectoris. Cardiology 64: 365

    Article  Google Scholar 

  54. Östmann-Smith I (1976) Prevention of exercise — induced cardiac hypertrophy in rats by chemical sympathectomy (guanethidine treatment). Neuroscience 1: 497–507

    Article  Google Scholar 

  55. Petersen ES, Whipp BJ, Dans JA, Huntsman DJ, Brown HV, Wasserman K (1983) Effects of beta-adrenergic blockade on ventilation and gas exchange during exercise in humans. J Appl Physiol 54: 1306–1313

    PubMed  CAS  Google Scholar 

  56. Pickering TG, Case DB, Sullivan PA, Laragh JH (1982) Comparison of antihypertensive and hormonal effects of captopril and propranolol at rest and during exercise. Am J Cardiol 49: 1566–1568

    Article  PubMed  CAS  Google Scholar 

  57. Raffestin B, Denjean A, Legrand A, Derrieux C, Boillot J, Comoy E, Martre H, Lockhart A (1985) Effects of nifedipine on responses to exercise in normal subjects. J Appl Physiol 58: 702–709

    Article  PubMed  CAS  Google Scholar 

  58. Reybrouck T, Amery A, Billiet L (1977) Hemodynamic response to graded exercise after chronic beta-adrenergic blockade. J Appl Physiol 42: 133 – 138

    PubMed  CAS  Google Scholar 

  59. Rost R (1983) Zur Frage der Bedeutung der Betablocker im Leistungssport. Dtsch Z Sportmed 34: 25–27,

    CAS  Google Scholar 

  60. Rost R (1983) Zur Frage der Bedeutung der Betablocker im Leistungssport. Dtsch Z Sportmed 34: 64–67

    Google Scholar 

  61. Rusko H, Kantola H, Luhtanen P, Pulli M, Videman T, Vütasalo JT (1980) Effect of beta-blockade on performances requiring force, velocity, coordination and/or anaerobic metabolism. J Sports Med 20: 139–144

    CAS  Google Scholar 

  62. Sable DL, Brammel HL, Sheehan MW, Nies AS, Gerber J, Horwitz LD (1982) Attenuation of exercise conditioning by beta-adrenergic blockade. Circulat 65: 679–684

    Article  CAS  Google Scholar 

  63. Schenk GK, Lang E, Anlauf M (1981) Beta-receptor-blocking therapy in hypertensive patients — effects on vigilance and behaviour. Aviat Space Environm Med 52: 35–39

    Google Scholar 

  64. Schnabel A, Kindermann W, Salas-Fraire O, Cassens J, Steinkraus V (1983) Effect of beta-adrenergic blockade on supramaximal exercise capacity. Int J Sports Med 4: 278–281

    Article  PubMed  CAS  Google Scholar 

  65. Schulte KL, Meyer-Sabellek WA, Thiede HM, Distler A, Gotzen R (1984) Blood pressure and sympathetic tone under calcium entry blockers in essential hypertension. Circulation 70: II-377

    Google Scholar 

  66. Sigvardsson K, Svanfeldt E, Kilbom Å (1978) Role of the adrenergic nervous system in development of training — induced bradycardia. Acta Physiol Scand 101: 481–488

    Article  Google Scholar 

  67. Siitonen L, Jänne J (1976) Effect of beta-blockade during bowling competition. Ann Clin Res 8: 393–398

    PubMed  CAS  Google Scholar 

  68. Simon G, Dickhuth HH, Lindscheidt G, Kindermann W, Keul J (1979) Hämodynamische und metabolische Auswirkungen der Beta-Rezeptoren-Blockade durch Metipranolol. Herz/Kreisl 11: 134–140

    CAS  Google Scholar 

  69. Smolarz A, Glocke M, Bartsch W, Kohl H (1979) Zur Wirkung des Beta-Blockers Metipranolol bei Sportschützen unter Wettkampfbedingungen. Dtsch Z Sportmed 30: 73–76

    Google Scholar 

  70. Stegmann H, Kindermann W, Schnabel A (1981) Lactate kinetics and individual anaerobic threshold. Int J Sports Med 2: 160–165

    Article  PubMed  CAS  Google Scholar 

  71. Stull JT, Mayer SE (1971) Regulation of phosphorylase activation in skeletal muscle in vivo. J Biol Chem 246: 5716–5723

    PubMed  CAS  Google Scholar 

  72. Trimarco B, De Luca N, Ricciardelli B, Volpe S, Veniero A, Cuocolo A, Cicala M (1984) Diltiazem in the treatment of mild or moderate essential hypertension. Comparison with metoprolol in a cross-over double-blind trial. J Clin Pharmacol 24: 218–227

    PubMed  CAS  Google Scholar 

  73. Videman T, Sonck T, Jänne J (1979) The effect of beta-blockade in ski jumpers. Med Sci Sports 11:266–269

    PubMed  CAS  Google Scholar 

  74. William-Olsson T, Fellenius E, Björntorp P, Smith U (1979) Differences in metabolic responses to β-adrenergic stimulation after propranolol or metoprolol administration. Acta Med Scand 205: 201–206

    Article  PubMed  CAS  Google Scholar 

  75. Yamakado T, Oonishi N, Kondo S, Noziri A, Nakano T, Takezawa H (1983) Effects of diltiazem on cardiovascular responses during exercise in systemic hypertension and comparison with propranolol. Am J Cardiol 52: 1023 – 1027

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung Sport- und Leistungsmedizin, Universität des Saarlandes, 6600, Saarbrücken, Deutschland

    W. Kindermann

Authors
  1. W. Kindermann
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kindermann, W. (1986). Die Beeinflussung der körperlichen Leistungsfähigkeit durch Antihypertensiva. In: Hochdruck und Sport. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87007-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-87007-1_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-99520-3

  • Online ISBN: 978-3-642-87007-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation