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Die funktionelle Orthologie der Lebersekretion

  • Chapter
Hilfsmechanismen des Stoffwechsels II

Part of the book series: Handbuch der allgemeinen Pathologie ((1711,volume 5 / 2))

Zusammenfassung

Ausgangspunkt für die Erforschung der Leberfunktionen ist die Hepatektomie am Tier. Minkowski (1886) führte dieses Experiment an der Gans, Mann (1921) am Hunde durch. Die Methodik spielt eine wichtige Rolle; der Grund ist folgender: Wird die Leber einfach nach Ligatur der Arterien und Venen entfernt, so kommt es bei Unterbindung der Pfortader zu Ausschluß und Abflußbehinderung des Blutes im Splanchnicusgebiet von der allgemeinen Zirkulation und damit zur Verminderung der Blutmenge, der das Tier erliegt. Mit dreizeitiger Operation gelingt es, diese Schwierigkeiten zu umgehen. Hunde, die nach der von Mann angegebenen Technik operiert werden, überleben 20–36 Std. Markowitz und Soskin (1927) vereinfachten die Methode, so daß die Leberentfernung zweizeitig möglich wurde. Verbesserte zweizeitige Methoden sind neuerdings von Chang (1951) für die Ratte und für den Hund von Grindlay und Mann (1952) angegeben worden. Eine einzeitige Methode nach Marko Witz, Yater und Burrows (1933) verbindet, vor Entfernung der Leber, die infra- und suprahepatischen Teile der Vena cava caudalis mit einer Pyrexglaskanüle und anastomosiert Pfortader mit unterer Hohlvene.

Aus der Medizinischen Universitätsklinik (Vorsteher: Prof. Dr. H. Staub).

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  1. Medizinischen Universitätsklinik, Basel, Switzerland

    Prof. Dr. H. Staub (Vorsteher)

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  1. E. Grogg
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A. Bohle J. Gayer A. Goebel E. Grogg H. A. Kühn A. Marchionini E. Randerath H. Sarre H. W. Spier H. Staub E. Letterer

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Grogg, E., Staub, H. (1959). Die funktionelle Orthologie der Lebersekretion. In: Bohle, A., et al. Hilfsmechanismen des Stoffwechsels II. Handbuch der allgemeinen Pathologie, vol 5 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87001-9_3

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