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Guillain-Barré Syndrome and Myasthenia Gravis

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Handbook of Evidence-Based Critical Care

Abstract

Clinical Features

  • Ascending symmetrical muscle weakness that evolves over several days to a week.

  • Nadir of neurologic deficit occurs by 28 days in 95% of cases.

  • Full recovery in 80% of patients.

  • Pain and aching discomfort in muscles.

  • Paraesthesias.

  • Hypotonia with absent reflexes.

  • Facial diplegia is common.

  • Autonomic dysfunction with fluctuating blood pressure and pulse, facial flushing, profuse diaphoresis.

  • Fisher syndrome: ophthalmoplegia, ataxia, areflexia.

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Selected Reference

  1. Randomised trial of plasma exchange, intravenous immunoglobulin, and combined treatments in Guillain-Barré syndrome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group. Lancet. 1997;349: 225–230.

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© 2001 Springer-Verlag New York, Inc.

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Marik, P.E. (2001). Guillain-Barré Syndrome and Myasthenia Gravis. In: Handbook of Evidence-Based Critical Care. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86943-3_41

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  • DOI: https://doi.org/10.1007/978-3-642-86943-3_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-78093-9

  • Online ISBN: 978-3-642-86943-3

  • eBook Packages: Springer Book Archive

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