The Mechanism of Action of Melanocyte Stimulating Hormone

  • Joseph S. McGuire
Part of the Symposion der Deutschen Gesellschaft für Endokrinologie book series (ENDOKRINOLOGIE, volume 8)


The mechanism of hormonal action is a central problem of biochemistry and physiology. There have been in the past few years promising attempts at its dissolution especially in the case of ACTH and the steroids, and there are hypotheses which may eventually be found to be correct. If by „the mechanism of action“ one means the initial unique reaction involving the hormone which ultimately accounts for its physiological effect, then at the present time we are unable to offer a completely satisfactory explanation for the mechanism of action of a single hormone. Before discussing current studies with MSH, I would like to discuss briefly the study of pigmentation as an area of interest to endocrinologists.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bourquelot, E., et G. Bertrand: C. R. Soc. Biol. (Paris) 47, 582 (1895).Google Scholar
  2. 2.
    Reviewed in Physiol. Rev. 30, 91 (1960).Google Scholar
  3. 3.
    Wrrrrch,’ W. vow: Arch. Anat. Physiol, u. Wiss. Med., p. 257 (1854).Google Scholar
  4. 4.
    Busces, W.: Arch. Anat. Physiol. u. Wiss. Med., p. 415 (1856).Google Scholar
  5. 5.
    Leydio, F.: Lehrbuch der Histologie des Menschen und der Tiere. Frankfurt: Meidinger 1857.Google Scholar
  6. 6.
    Briiecke, E.: Denkschr. Kgl. Acad. Wiss. Wien 4, 179 (1852).Google Scholar
  7. 7.
    Smith, P. E.: Science 44, 280 (1916).PubMedCrossRefGoogle Scholar
  8. 8.
    Allen, B. M.: Science 44, 755 (1916).CrossRefGoogle Scholar
  9. 9.
    Atwell, W. J.: Science 49, 48 (1919).PubMedCrossRefGoogle Scholar
  10. 10.
    Swingle, W. W.: J. exp. Zool. 34, 119 (1921).CrossRefGoogle Scholar
  11. 11.
    Zondek, B., and H. Krohn: Klin. Wschr. 11, 405 (1932).CrossRefGoogle Scholar
  12. 12.
    Lerner, A. B., and T. H. LEE: J. Amer. chem. Soc. 77, 1066 (1955).CrossRefGoogle Scholar
  13. 13.
    Harris, J. I., and P. Roos: Nature (Lond.) 178, 90 (1956).CrossRefGoogle Scholar
  14. 14.
    Geschwind, I. I. C. H. Li, and L. Barnafi: J. Amer. chem. Soc. 78, 4494 (1956).Google Scholar
  15. 15.
    Lee, T. H., A. B. Lerner and V. Buettner-Janusch: J. Amer. chem. Soc. 81, 6084 (1959).CrossRefGoogle Scholar
  16. 16.
    Li, C. H., I. I. Geschwind, R. D. Cole, I. D. Roocke, J. I. Harris and J. S. Dixon: Nature (Lond.) 176, 687 (1955).CrossRefGoogle Scholar
  17. 17.
    Ballowrrz, E.: Pflüger’s Arch. ges. Physiol. 157, 165 (1914).Google Scholar
  18. 18.
    Matthews, S. A.: J. exptl. Zool. 58, 471 (1931).CrossRefGoogle Scholar
  19. 19.
    Gilson, A. S.: J. exptl. Zool. 45, 415 (1926).CrossRefGoogle Scholar
  20. 20.
    Marsland, D. A.: Biol. Bull. 87, 252 (1944).CrossRefGoogle Scholar
  21. 21.
    De Buy, H. G., M. W. Woods, D. Burk and M. D. Lackey: J. nat. Cancer Inst. 9, 325 (1949).Google Scholar
  22. 22.
    Baker, R. V., M. S. C. Birbeck, H. Blaschko, T. B. Fitzpatrick and M. Seiji: Nature (Lond.) 187, 392 (1960).CrossRefGoogle Scholar
  23. 23.
    Haynes, R. C.: J. biol. Chem. 233, 1219 (1958).Google Scholar
  24. 24.
    Haynes, R. C., S. B. Koritz and F. G. Peron: J. biol. Chem. 234, 1421 (1959).PubMedGoogle Scholar
  25. 25.
    Rall, T W., and E. W. Sutherland• J biol. Chem. 232, 1065 (1958).Google Scholar
  26. 26.
    Rosenberg, I. N.: Proc. Soc. exper. Biol. (N. Y.) 82, 701 (1953).Google Scholar
  27. 27.
    Raben, M S., R. Landolt, F. A. Smith, K. Hofmann and H. Yajima: Nature (Lond.) 189, 681 (1961).Google Scholar
  28. 28.
    Lerner, A. B., and J. S. McGuire: Nature (Lond.) 189, 176 (1961).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1962

Authors and Affiliations

  • Joseph S. McGuire
    • 1
  1. 1.Section of Dermatology, Department of MedicineYale University School of MedicineNew HavenUSA

Personalised recommendations