Human Germinal Centers Lymph Nodes Responses to Leukemogenic Viruses in vitro

  • L. Jankay
  • P. T. Jankay
  • S. Liu
  • B. Samp

Abstract

The responses of the lymphoid system of different species of animals to various antigens are well documented. In our experiments we made an approach to study the responses of human lymph nodes and human peripheral heparinized whole blood, to the presence of animal leukemogenic virus (Rauscher)2 in vitro. This study revealed that human lymph node and whole blood respond to the Rauscher leukemia virus with a pattern of formation of large basophilic blast-like cells demonstrating mitotic activity, large mononuclear cells with intranuclear inclusion bodies and plasma cells.

Keywords

Lymphoma Leukemia Sedimentation Germinal Paraffin 

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References

  1. André-Schwartz, J.: The morphologic responses of the lymphoid system to homografts. III. Electron microscopy study. Blood 24, 113–133 (1964).PubMedGoogle Scholar
  2. Bain, B., and L. Lowenstein: Genetic studies on the mixed leucocyte reactions. Science 145, 1315–1316 (1964).PubMedCrossRefGoogle Scholar
  3. Gross, L.: Viral etiology of leukemia and lymphomas. Blood 25, 377–381 (1965).PubMedGoogle Scholar
  4. Jankay, L.: 9th Congress of the European Society of Hematology. Sangre 9, 199–204 (1964).Google Scholar
  5. Jankay, L. and L. J. Cole: Research and development technical report. USNRDL-TR-S-Roll 0101, 1960.Google Scholar
  6. Jankay, L., and B. Kurnick: Cultivation of human bone marrow and cancer cell in autologous-heparinized whole blood. Blood 20, 104 (1962) (Abstract).Google Scholar
  7. Oppenheim, J. J., J. Whang, and E. Frei: III. Immunologic and cytogenetic studies of chronic lymphocytic leukemia cells. Blood 26, 121–132 (1965).PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

  • L. Jankay
  • P. T. Jankay
  • S. Liu
  • B. Samp
    • 1
    • 2
  1. 1.Harbor General HospitalTorranceUSA
  2. 2.Studebaker HospitalNorwalkUSA

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