De novo Formation and Rapid Growth of Germinal Centers During Secondary Antibody Responses to Tetanus Toxoid in Mice
a time interval of several months is used between the first and second injection of antigen;
the site of secondary stimulation differs from the site of primary immunization;
the booster injection is given at a site where the draining lymph nodes in non-stimulated animals contain no, or only a few, germinal centers.
KeywordsMigration Germinal Lime Thymidine Nucleoside
Unable to display preview. Download preview PDF.
- Cottier, H.: unpublished data (1966).Google Scholar
- Cottier, H, B. Roos, S. Dübi, N. Odartchenko, G. Keiser, M. Hess, and R. D. Stoner: Cytokinetics of lymphoreticular tissue during secondary response to tetanus toxoid in mice. In: The lymphocyte in immunology and haemopoiesis (J. M. Yoffeyed.). London: Arnold (1967) pp. 324–332.Google Scholar
- Maruyama, K.: Electron microscopic studies on the cells of the lymphatic germinal center. Proc. IVth Int. Symposium of R.E.S., Otsu and Kyoto (1964), pp. 73–83.Google Scholar
- Thorbecke, G. J., R. M. Asofsky, G. M. Hochwald, and G. W. Siskind: Gamma globulin formation in vitro. III. Induction of secondary response at different intervals after the primary; the role of secondary nodules in the preparation for the secondary response. J. exp. Med. 116, 295–310 (1962).PubMedCrossRefGoogle Scholar
- Turk, J. L., and J. Oort: Germinal center activity in relation to delayed hypersensitivity. This Symposium.Google Scholar