De novo Formation and Rapid Growth of Germinal Centers During Secondary Antibody Responses to Tetanus Toxoid in Mice
a time interval of several months is used between the first and second injection of antigen;
the site of secondary stimulation differs from the site of primary immunization;
the booster injection is given at a site where the draining lymph nodes in non-stimulated animals contain no, or only a few, germinal centers.
KeywordsRegional Lymph Node Germinal Center Tetanus Toxoid Secondary Response Popliteal Lymph Node
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