Phylogenetic and Ontogenetic Considerations
All expressions of acquired immunity, such as humoral antibody formation, immediate and delayed hypersensitivity, and transplantation immunity, are based on the organism’s ability to a) specifically recognize antigenic determinants, b) actively produce specific protein molecules, and c) develop mechanisms by which the antigen may be recognized in anamnestic situations. These specialized reactions appear to depend on the normal development and function of a lymphoreticular system.
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