Abstract
Inasmuch as heritable changes are primarily caused by mutations affecting individual cistrons within the genome, the accurate estimation of the spontaneous mutation rate is of the utmost importance in understanding evolution. Furthermore, in view of the fact that a mutation randomly affects a single base pair of any cistron and that only some of the mutations are permitted by natural selection to accompany the process of speciation, we should also have some idea about relative proportions with regard to forbidden versus tolerable mutations. In practice, it is convenient to consider the spontaneous mutation rate either in terms of per locus per generation or per base pair per generation.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bailey, D.W.: Heritable histocompatibility changes: Lysogeny in mice?. Transplantation 4, 482–488 (1966).
Baker, C.M.A., Manwell, C.: Molecular genetics of avian proteins. VIII. Egg white proteins of the migratory quail, Coturnix coturnix. New concepts of “hybrid vigour”. Comp. Biochem. Physiol. 23, 21–42 (1967).
Bender, K., Ohno, S.: Duplication of the autosomally inherited 6-phosphogluconate dehydrogenase gene locus in tetraploid species of Cyprinid fish. Biochem. Genet. 2, 101–107 (1968).
Fitch, W.M.: An improved method of testing for evolutional homology. J. Mol. Biol. 16, 9–16 (1966).
Harris, H.: Enzyme and protein polymorphism. Brit. Med. Bull. 25, 5–13 (1969).
Kimura, M.: Evolutionary rate at the molecular level. Nature 217, 624–626 (1968).
— Crow, J.F.: The number of alíeles that can be maintained in a finite population. Genetics 49, 725–738 (1964).
Lyon, M.F.: Some evidence concerning the “mutational load” in inbred strains of mice. Heredity 13, 334–352 (1959).
Margoliash, E.: Sequence and structure of Cytochrome C. Advances in Protein Chem. 21, 113–286 (1966).
Ohno, S., Stenius, C., Christian, L.C., Harris, C.: Synchronous activation of both parental alíeles at the 6-PGD locus of Japanese quail embryos. Biochem. Genet. 2, 197–204 (1968).
— Schipmann, G.: De novo mutation-like events observed at the 6-PGD locus of the Japanese quail, and the principle of polymorphism breeding more polymorphism. Biochem. Genet. 3, 417–428 (1969).
Parr, C.W.: Erythrocyte phosphogluconate dehydrogenase polymorphism. Nature 210, 487–489 (1966).
Russell, W.L.: X-ray induced mutations in mice. Cold Spring Harbor Symposia Quant. Biol. 16, 327–336 (1951).
Salthe, S.N.: Geographic variation of the lactate dehydrogenases of Rana pipiens and Rana palustris. Biochem. Genet. 2, 271–304 (1969).
Shaw, C.R.: Electrophoretic variation in enzymes. Science 149, 936–943 (1965).
Slatis, H.M.: Comments on the rate of mutation to chondrodystrophy in man. Am. J. Human Genet. 7, 76–79 (1955).
Stevenson, A.C.: Comparisons of mutation rates at single loci in man. In: Effect of radiation on human heredity, pp. 125–137. Geneva: World Health Organization 1957.
Stormont, C.: Mammalian immunogenetics. In: Genetics today (Geerts, S.J., Ed.), Vol. 3, Chapter 19, pp. 716–722. New York: Pergamon Press 1965.
Thüline, H.C., Morrow, A.C., Norby, D.E., Motulsky, A.G.: Autosomal phosphogluconic dehydrogenase polymorphism in the cat. (Felts cattus L.). Science 157, 431–432 (1967).
Whitfield, H.J., Martin, R.G., Ames, B.N.: Classification of aminotransferase (C gene) mutants in the histidine operon. J. Mol. Biol. 21, 335–355 (1966).
Wright, J.E., Atherton, L.: Genetic control of interallelic recombination at the LDH B locus in brook trout. Genetics 60, 240 (1968).
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1970 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ohno, S. (1970). The Spontaneous Mutation Rate. In: Evolution by Gene Duplication. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86659-3_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-86659-3_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-86661-6
Online ISBN: 978-3-642-86659-3
eBook Packages: Springer Book Archive