Only the amino acid sequence of a polypeptide chain defines its function. A polypeptide chain having a certain amino acid sequence serves as a subunit of immunoglobulin, while another polypeptide chain having a different amino acid sequence functions as a subunit of an enzyme, such as lactate dehydrogenase. It then follows that a change in the amino acid sequence of a polypeptide chain can deprive that polypeptide chain from the performance of its assigned function.
KeywordsNatural Selection Polypeptide Chain Disulfide Bridge Peptide Chain Heme Group
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- Gerald, P.S., Scott, E.M.: The hereditary methemoglobinemias. In: The metabolic basis of inherited disease, 2nd ed., pp. 1090–1099.Google Scholar
- Stanbury, J.B., Wyngaarden, J.B., Frederickson, D.S. Eds. New York: McGraw-Hill Book Co. 1966.Google Scholar
- Jervis, G.A.: Phenylpyruvic oligophrenia: Deficiency of phenylalanine oxydizing system. Proc. Soc. Exptl. Biol. Med. 82, 514 (1953).Google Scholar
- Kaplan, N.O.: Evolution of dehydrogenases. In: Evolving genes and proteins, Bryson, V. Vogel, J.H., Eds. New York: Academic Press 1965.Google Scholar
- Searle, A.G.: Comparative genetics of coat colour in mammals. London: Logos Press, Ltd. 1968.Google Scholar
- Wolfe, H.G., Coleman, D.L.: Pigmentation, In: Biology of the laboratory mouse, 2nd ed. Green, E.L., Ed. New York: McGraw-Hill 1966.Google Scholar