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Tandem Duplication Involving Part of One Linkage Group at a Time

  • Susumu Ohno

Abstract

Just as mutation is the consequence of a mistake in DNA replication, gene duplication also arises as an infrequent mistake in mitotic as well as meiotic processes. Duplication which involves a single cistron or a cluster of cistrons on one linkage group is dealt with in this chapter. This mode of gene duplication can be contrasted with the simultaneous duplication of all linkage groups due to polyploidy (to be dealt with in a later chapter).

Keywords

Linkage Group Gene Locus Gene Duplication Sister Chromatid Duplicate Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baglioni, C.: Abnormal human hemoglobins. X. A study of hemoglobin Lepore Boston. Biochim. et Biophys. Acta 97, 37–46 (1965).CrossRefGoogle Scholar
  2. Benirschke, K., Malouf, N., Low, R.J.: Chromosome complement: Difference between Equus caballus and Equus przewalskii, Poliakoff. Science 148, 382–383 (1965).PubMedCrossRefGoogle Scholar
  3. Callan, H.G.: The organization of genetic units in chromosomes. J. Cell Sci. 2, 1–7 (1967).PubMedGoogle Scholar
  4. Comings, D.E., Berger, R.O.: Gene products of amphiuma: An amphibian with an excessive amount of DNA. Biochem. Genet. 2, 319–333 (1969).PubMedCrossRefGoogle Scholar
  5. Gilman-Sachs, A., Mage, R.G., Young, G.O., Alexander, C., Dray, S.: Identification and genetic control of two rabbit immunoglobulin allotypes at a second light chain locus, the c locus. J. Immunology, 103, 1159–1167 (1969).Google Scholar
  6. Herzenberg, L.A., Minna, J.D., Herzenberg, L.A.: The chromosome region for immunoglobulin heavy-chains in the mouse. Cold Spring Harbor Symposia Quant. Biol. 32, 181–186 (1967).CrossRefGoogle Scholar
  7. Hill, R.L., Buettner-Janusch, J., Buettner-Janusch, V.: Evolution of hemoglobin in primates. Proc. Natl. Acad. Sci. US 50, 885–893 (1963).CrossRefGoogle Scholar
  8. Ingram, V.M., Stretton, A.O.W.: Human hemoglobin A2. I. Comparison of hemoglobins A2 and A. Biochim. et Biophys. Acta 62, 456–474 (1962).Google Scholar
  9. Keyl, H.G.: Increase of DNA in chromosomes. In: Chromosomes today, Vol. 1, pp. 99–101. (Darlington, C.D., Lewis, K.R., Eds.). London: Oliver & Boyd 1966.Google Scholar
  10. Kilmartin, J.V., Clegg, J.B.: Amino-acid replacements in horse hemoglobin. Nature 213, 269–271 (1967).PubMedCrossRefGoogle Scholar
  11. Mirsky, A.E., Ris, H.: The desoxyribonucleic acid content of animal cells and its evolutionary significance. J. Gen. Physiol. 34, 451–462 (1951).PubMedCrossRefGoogle Scholar
  12. Natvig, J.B., Kunkel, H.G., Litwin, S.P.: Genetic markers of the heavy-chain subgroups of human gamma G globulin. Cold Spring Harbor Symposia Quant. Biol. 32, 173–180 (1967).CrossRefGoogle Scholar
  13. Ohno, S., Atkin, N.B.: Comparative DNA values and chromosome complements of eight species of fishes. Chromosoma 18, 455–466 (1966).PubMedCrossRefGoogle Scholar
  14. Oudin, J.: Genetic regulation of immunoglobulin synthesis. J. Cell Physiol. 67, 77–108 (1966).PubMedCrossRefGoogle Scholar
  15. Ritossa, F.M., Atwood, K.M., Spiegelman, S.: A molecular explanation of the bobbed mutants of Drosophila as partial deficiencies of “ribosomal” DNA. Genetics 54, 819–834 (1966).PubMedGoogle Scholar
  16. Smithies, O., Cornell, G.E., Dixon, G.H.: Chromosomal rearrangements and protein structure. Cold Spring Harbor Symposia Quant. Biol. 29, 309–319 (1964).CrossRefGoogle Scholar
  17. Sturtevant, A.H.: The effects of unequal crossing-over at the Bar locus in Drosophila, Genetics 10, 117–147 (1925).PubMedGoogle Scholar
  18. Taylor, J.H., Woods, P.S., Hughes, W.L.: The organization and duplication of chromosomes as revealed by autoradiographic studies using tritium-labeled thymidine. Proc. Natl. Acad. Sci. US 43, 122–128 (1957).CrossRefGoogle Scholar
  19. Todd, C.W.: Allotypy in rabbit 19S protein. Biochem. Biophys. Res. Commun. 11, 170 to 175 (1963).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1970

Authors and Affiliations

  • Susumu Ohno
    • 1
  1. 1.Department of BiologyCity of Hope Medical CenterDuarteUSA

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