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Preoperative Chemotherapy and Surgical Resection for Squamous Cell Carcinoma of the Esophagus

  • A. D. Hilgenberg
  • R. W. Carey
  • N. C. Choi
  • D. J. Mathisen
  • E. W. WilkinsJr.
  • H. C. Grillo
Conference paper

Abstract

In an attempt to increase the long-term survival rate of patients with squamous cell carcinoma of the esophagus, we developed a treatment protocol consisting of a combination of preoperative chemotherapy, surgical resection, and in selected patients postoperative radiation and/or chemotherapy [1]. Our intent is to use a reasonably simple and brief preoperative regimen with low toxicity, followed by a standard transthoracic esophageal resection. Then based on the patient’s response to chemotherapy, the pathologic findings in the resected esophageal specimen, and the patient’s postoperative nutritional status, selectively to administer postoperative therapy. We elected to use the chemotherapy regimen proposed by Leichman et al. [2], consisting of 5-fluorouracil and Cisplatin, and carried out radiologic, endoscopic, and surgical evaluation of the effects of the chemotherapy. We omitted the preoperative radiotherapy proposed by Leichman et al. [2] in order to simplify the regimen and perhaps to decrease the high hospital mortality rate cited in their report.

Keywords

Squamous Cell Carcinoma Preoperative Chemotherapy Complete Clinical Response Postoperative Therapy Partial Clinical Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Carey RW, Hilgenberg AD, Wilkins EW et al. (1986) Preoperative chemotherapy followed by surgery with possible postoperative radiotherapy in squamous cell carcinoma of the esophagus: evaluation of the chemotherapy component. J Clin Oncol 4:697–701PubMedGoogle Scholar
  2. 2.
    Leichman L, Steiger Z, Seydel HG et al. (1984) Preoperative chemotherapy and radiation therapy for patients with cancer of the esophagus: a potentially curative approach. J Clin Oncol 2:75–79PubMedGoogle Scholar
  3. 3.
    Katlic MR, Grillo HC (1983) Carcinoma of the espphagus: a current perspective. In: Choi NC, Grillo HC (eds) Thoracic oncology. Raven, New York, p 294Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • A. D. Hilgenberg
    • 1
  • R. W. Carey
    • 1
  • N. C. Choi
    • 1
  • D. J. Mathisen
    • 1
  • E. W. WilkinsJr.
    • 1
  • H. C. Grillo
    • 1
  1. 1.Departments of Surgery, Medicine, and Radiation MedicineMassachusetts General Hospital and Harvard Medical SchoolBostonUSA

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