Preoperative Chemotherapy and Surgical Resection for Squamous Cell Carcinoma of the Esophagus
In an attempt to increase the long-term survival rate of patients with squamous cell carcinoma of the esophagus, we developed a treatment protocol consisting of a combination of preoperative chemotherapy, surgical resection, and in selected patients postoperative radiation and/or chemotherapy . Our intent is to use a reasonably simple and brief preoperative regimen with low toxicity, followed by a standard transthoracic esophageal resection. Then based on the patient’s response to chemotherapy, the pathologic findings in the resected esophageal specimen, and the patient’s postoperative nutritional status, selectively to administer postoperative therapy. We elected to use the chemotherapy regimen proposed by Leichman et al. , consisting of 5-fluorouracil and Cisplatin, and carried out radiologic, endoscopic, and surgical evaluation of the effects of the chemotherapy. We omitted the preoperative radiotherapy proposed by Leichman et al.  in order to simplify the regimen and perhaps to decrease the high hospital mortality rate cited in their report.
KeywordsToxicity Hydration Creatinine Barium Mannitol
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