A Possible Triggering Mechanism Producing Acid Gastroesophageal Reflux in Duodenal Ulcer Patients and Normal Volunteers

  • S. Kruse-Andersen
  • L. Wallin
  • T. Madsen
Conference paper


Nocturnal gastroesophageal reflux is believed to play an important part in the pathogenesis of reflux esophagitis. The majority of gastroesophageal reflux episodes have been shown to be caused by sudden critical pressure drops in the gastroesophageal sphincter, and only a minority of reflux episodes are caused by persistently low sphincter pressure [1,2]. A major part of the esophageal pressure activity that occurs during the night appears as brief clusters of contractile activity during arousal from sleep [1,3]. An increased occurrence of abnormal contractions in these short periods of motor activity has been noted [1].


Gastroesophageal Reflux Reflux Esophagitis Acid Reflux Pressure Activity Reflux Episode 
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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • S. Kruse-Andersen
    • 1
  • L. Wallin
    • 1
  • T. Madsen
    • 1
  1. 1.Esophagus Laboratory, Department of Thoracic and Cardiovascular Surgery TOdense University HospitalOdenseDenmark

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