A Possible Triggering Mechanism Producing Acid Gastroesophageal Reflux in Duodenal Ulcer Patients and Normal Volunteers
Nocturnal gastroesophageal reflux is believed to play an important part in the pathogenesis of reflux esophagitis. The majority of gastroesophageal reflux episodes have been shown to be caused by sudden critical pressure drops in the gastroesophageal sphincter, and only a minority of reflux episodes are caused by persistently low sphincter pressure [1,2]. A major part of the esophageal pressure activity that occurs during the night appears as brief clusters of contractile activity during arousal from sleep [1,3]. An increased occurrence of abnormal contractions in these short periods of motor activity has been noted .
KeywordsGastroesophageal Reflux Reflux Esophagitis Acid Reflux Pressure Activity Reflux Episode
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Dent J, Dodds WJ, Friedman RH (1980) Mechanism of gastroesophageal reflux in recu-ment asymptomatic human subjects. J Clin Invest 65:256–267PubMedCrossRefGoogle Scholar
Dodds WJ, Dent J, Hogan WJ (1982) Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med 307:1547–1552PubMedCrossRefGoogle Scholar
Lichter I, Muir RC (1975) The pattern of swallowing during sleep. Electroencephalogr Clin Neurophysiol 38:427–432PubMedCrossRefGoogle Scholar
Wallin L, Madsen T, Boesby S, Sorensen O (1979) Gastro-oesophageal acid reflux and oesophageal peristalsis. Method for 12-hour simultaneous recording of pH and peristaltic activity in the oesophagus. Scand J Gastroenterol 14:481–487PubMedGoogle Scholar
Corazziari E, Bontempo I, Anzini F, Torsoli A (1984) Motor activity of the distal oesophagus and gastro-oesophageal reflux. Gut 25:7–13PubMedCrossRefGoogle Scholar
Baldi F, Ferrarini F, Balestra R (1985) Oesophageal motor events at the occurrence of acid reflux and during endogenous acid exposure in healthy subjects and in patients with oesophagitis. Gut 26:336–341PubMedCrossRefGoogle Scholar