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Deranged Fasting Motor Activity in the Duodenum and Proximal Small Intestine in Patients with Reflux Esophagitis

  • K. Thor
  • S. Fürstenberg
Conference paper

Abstract

Gastroesophageal reflux (GER) is associated with esophageal motor disorders, reduced lower esophageal sphincter (LES) pressure, and delayed gastric emptying. Even with a normal resting LES pressure GER may occur due to transient relaxation of the sphincter after gastric distention (Holloway et al. 1985). Taken together, this indicates that GER might be a manifestation of a general smooth muscle disorder rather than just a disease of the LES.

Keywords

Gastric Emptying Lower Esophageal Sphincter Reflux Esophagitis Lower Esophageal Sphincter Pressure Activity Front 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Holloway RH, Hongo M, Berger K, McCallum RW (1985) Gastric distension: a mechanism for postprandial gastroesophageal reflux. Gastroenterology 89:779–784PubMedGoogle Scholar
  2. 2.
    Jian R, Ducrot F, Piedeloup C, Mary JY, Najean Y, Bernier JJ (1985) Measurement of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent (Cisapride). Gut 26:352–358PubMedCrossRefGoogle Scholar
  3. 3.
    Smout AJPN, Bogaard JW, Grade AC, Ten Thije OJ, Akkermans LMA, Wittebol P (1985) Effects of Cisapride, a new gastrointestinal prokinetic substance, on interdigestive and postprandial motor activity of the distal esophagus in man. Gut 26:246–251PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • K. Thor
    • 1
  • S. Fürstenberg
    • 1
  1. 1.Department of SurgeryErsta HospitalStockholmSweden

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