Effect of Vasoactive Intestinal Polypeptide on the Cardiac Closing Mechanism and Pathophysiology of Achalasia of the Esophagus
Vasoactive intestinal polypeptide (VIP) is a 28 amino acid polypeptide with a close structural and functional relationship to secretin and glucagon . VIP is localized not only in the gastrointestinal tract but also in central and peripheral neurons. We investigated the role of gastrointestinal hormones on the cardiac closing mechanism . In this study, the effects of VIP and secretin were investigated in experimental achalasia dogs and achalasia patients with the manometric method and immunohistochemical technique.
KeywordsVasoactive Intestinal Polypeptide Myenteric Plexus Lower Esophageal Sphincter Pressure Amino Acid Polypeptide Esophageal Achalasia
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- 1.Mutt V, Said SI (1974) Structure of porcine vasoactive intestinal octacosapeptide. Eur J Bio-chem 21:581–589Google Scholar
- 2.Ishigami K, Murakami T (1985) Gastrointestinal hormones and operations for achalasia of the esophagus and sliding esophageal hiatal hernia, their surgical significance. J Jpn Surg Soc 86(9): 1153–1156Google Scholar
- 3.Deloyer L, Cordier R (1957) A new approach to the physiology of so called cardiospasm. Experimental production of cardiospasm in cats after destruction of Auerbach’s plexus. Ann Surg 146:167–176Google Scholar
- 4.Goyal RK, Rattan S (1981) Neurohormonal, hormonal and drug receptors for the lower esophageal function. Med Surg Probl Esophagus: 18–21Google Scholar