Effect of Vasoactive Intestinal Polypeptide on the Cardiac Closing Mechanism and Pathophysiology of Achalasia of the Esophagus

  • A. Tangoku
  • K. Ishigami
  • T. Murakami
Conference paper

Abstract

Vasoactive intestinal polypeptide (VIP) is a 28 amino acid polypeptide with a close structural and functional relationship to secretin and glucagon [1]. VIP is localized not only in the gastrointestinal tract but also in central and peripheral neurons. We investigated the role of gastrointestinal hormones on the cardiac closing mechanism [2]. In this study, the effects of VIP and secretin were investigated in experimental achalasia dogs and achalasia patients with the manometric method and immunohistochemical technique.

Keywords

Phenol Polypeptide Luminal Glucagon Secretin 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • A. Tangoku
    • 1
  • K. Ishigami
    • 1
  • T. Murakami
    • 1
  1. 1.The 2nd Surgical DivisionYamaguchi University School of MedicineUbe, Yamaguchi 755Japan

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