Skip to main content
SpringerLink
Log in

Effect of Vasoactive Intestinal Polypeptide on the Cardiac Closing Mechanism and Pathophysiology of Achalasia of the Esophagus

  • Conference paper
Diseases of the Esophagus

Abstract

Vasoactive intestinal polypeptide (VIP) is a 28 amino acid polypeptide with a close structural and functional relationship to secretin and glucagon [1]. VIP is localized not only in the gastrointestinal tract but also in central and peripheral neurons. We investigated the role of gastrointestinal hormones on the cardiac closing mechanism [2]. In this study, the effects of VIP and secretin were investigated in experimental achalasia dogs and achalasia patients with the manometric method and immunohistochemical technique.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Mutt V, Said SI (1974) Structure of porcine vasoactive intestinal octacosapeptide. Eur J Bio-chem 21:581–589

    Google Scholar 

  2. Ishigami K, Murakami T (1985) Gastrointestinal hormones and operations for achalasia of the esophagus and sliding esophageal hiatal hernia, their surgical significance. J Jpn Surg Soc 86(9): 1153–1156

    CAS  Google Scholar 

  3. Deloyer L, Cordier R (1957) A new approach to the physiology of so called cardiospasm. Experimental production of cardiospasm in cats after destruction of Auerbach’s plexus. Ann Surg 146:167–176

    Google Scholar 

  4. Goyal RK, Rattan S (1981) Neurohormonal, hormonal and drug receptors for the lower esophageal function. Med Surg Probl Esophagus: 18–21

    Google Scholar 

  5. Cohen S, Lipshutz W (1971) Homonal regulation of human LES. J Clin Invest 50:449–454

    Article  PubMed  CAS  Google Scholar 

  6. Siegel SR, Brown FC (1979) Effect of vasoactive intestinal polypeptide on lower esophageal sphincter in awake baloons, comparison with glucagon and secretin. Dig Dis Sci 24:345–349

    Article  PubMed  CAS  Google Scholar 

  7. Aggestrup S, Uddman R (1983) Lack of vasoactive intestinal polypeptide nerves in esophageal achalasia. Gastroenterology 84:924–927

    PubMed  CAS  Google Scholar 

  8. Cannon WB (1939) A law of denervation. Am J Med Sci 198:737–750

    Article  Google Scholar 

  9. Siewert R, Früh E (1973) Senkung des Druckes im unteren Oesophagussphinkter bei Achalasia durch Glucagon. Dtsch Med Wochenschr 98:2045–2046

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The 2nd Surgical Division, Yamaguchi University School of Medicine, Ube, Yamaguchi 755, Japan

    A. Tangoku, K. Ishigami & T. Murakami

Authors
  1. A. Tangoku
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Ishigami
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Murakami
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, D-8000, Munich 80, Federal Republic of Germany

    J. R. Siewert M.D. FACS (Professor of Surgery) & A. H. Hölscher M.D. (Professor of Surgery) & 

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag

About this paper

Cite this paper

Tangoku, A., Ishigami, K., Murakami, T. (1988). Effect of Vasoactive Intestinal Polypeptide on the Cardiac Closing Mechanism and Pathophysiology of Achalasia of the Esophagus. In: Siewert, J.R., Hölscher, A.H. (eds) Diseases of the Esophagus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86432-2_204

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-86432-2_204

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-86434-6

  • Online ISBN: 978-3-642-86432-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation