Effect of Vasoactive Intestinal Polypeptide on the Cardiac Closing Mechanism and Pathophysiology of Achalasia of the Esophagus

  • A. Tangoku
  • K. Ishigami
  • T. Murakami
Conference paper


Vasoactive intestinal polypeptide (VIP) is a 28 amino acid polypeptide with a close structural and functional relationship to secretin and glucagon [1]. VIP is localized not only in the gastrointestinal tract but also in central and peripheral neurons. We investigated the role of gastrointestinal hormones on the cardiac closing mechanism [2]. In this study, the effects of VIP and secretin were investigated in experimental achalasia dogs and achalasia patients with the manometric method and immunohistochemical technique.


Vasoactive Intestinal Polypeptide Myenteric Plexus Lower Esophageal Sphincter Pressure Amino Acid Polypeptide Esophageal Achalasia 
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  1. 1.
    Mutt V, Said SI (1974) Structure of porcine vasoactive intestinal octacosapeptide. Eur J Bio-chem 21:581–589Google Scholar
  2. 2.
    Ishigami K, Murakami T (1985) Gastrointestinal hormones and operations for achalasia of the esophagus and sliding esophageal hiatal hernia, their surgical significance. J Jpn Surg Soc 86(9): 1153–1156Google Scholar
  3. 3.
    Deloyer L, Cordier R (1957) A new approach to the physiology of so called cardiospasm. Experimental production of cardiospasm in cats after destruction of Auerbach’s plexus. Ann Surg 146:167–176Google Scholar
  4. 4.
    Goyal RK, Rattan S (1981) Neurohormonal, hormonal and drug receptors for the lower esophageal function. Med Surg Probl Esophagus: 18–21Google Scholar
  5. 5.
    Cohen S, Lipshutz W (1971) Homonal regulation of human LES. J Clin Invest 50:449–454PubMedCrossRefGoogle Scholar
  6. 6.
    Siegel SR, Brown FC (1979) Effect of vasoactive intestinal polypeptide on lower esophageal sphincter in awake baloons, comparison with glucagon and secretin. Dig Dis Sci 24:345–349PubMedCrossRefGoogle Scholar
  7. 7.
    Aggestrup S, Uddman R (1983) Lack of vasoactive intestinal polypeptide nerves in esophageal achalasia. Gastroenterology 84:924–927PubMedGoogle Scholar
  8. 8.
    Cannon WB (1939) A law of denervation. Am J Med Sci 198:737–750CrossRefGoogle Scholar
  9. 9.
    Siewert R, Früh E (1973) Senkung des Druckes im unteren Oesophagussphinkter bei Achalasia durch Glucagon. Dtsch Med Wochenschr 98:2045–2046PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • A. Tangoku
    • 1
  • K. Ishigami
    • 1
  • T. Murakami
    • 1
  1. 1.The 2nd Surgical DivisionYamaguchi University School of MedicineUbe, Yamaguchi 755Japan

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