Disordered Motor Activity of the Esophagus in Sclerodermic Patients with Gastroesophageal Reflux and Duodenogastric Reflux: pH-Manometric Study

  • N. Di Martino
  • G. Amato
  • L. Feil
  • G. Izzo
  • V. Maffettone
  • A. Cosenza
  • F. Donati
  • A. Del Genio
Conference paper


The term sclerodermia was proposed by Gintrac in 1847 [20], but the first clinical description of the disease is due to a neapolitan physician Carlo Curzio in 1753. Nowadays this term is mostly used to indicate the cutaneous localization of the disease [35]. Cases of generalized disease are usually referred to as systemic sclerosis [39]. According to Matheas [33], the use of the expression progressive systemic sclerosis, (PSS), which has pleased Anglo-Saxon authors so much [24], is not justified, since the disease course is very lengthy in most cases.


Gastroesophageal Reflux Reflux Esophagitis Cutaneous Localization Sclerodermic Patient Duodenogastric Reflux 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Altomonte L, Zoli A, Alessi F, Ghirlanda G, Greco AV, Magarò M (1985) Aspetti gastroenterologici delle malattie del tessuto connettivo. Minerva Chir 76:1323–1329Google Scholar
  2. 2.
    Battle WM, Snape WJ Jr, Wright S (1981) Abnormal colonic motility in progressive systemic sclerosis. Ann Intern Med 94:749–752PubMedGoogle Scholar
  3. 3.
    Cohen S (1980) The gastrointestinal manifestations of scleroderma: pathogenesis and management. Gastroenterology 79:155–166PubMedGoogle Scholar
  4. 4.
    Debray E, Leymarios J (1972) Intestin gréle et duodenum dans la sclérose systémique progressive. In: Delbarre F (ed) La sclérodermie. Masson, Paris, pp 99–107Google Scholar
  5. 5.
    Genio A Del (1978) La nostra esperienza in tema di elettromanometria esofagea. Accad Sci Med Palermo [Suppl 1] 12:59–69Google Scholar
  6. 6.
    Genio A Del (1985) Il reflusso gastro-esofageo. In: Ferrarese S (ed) Fisiopatologia chirurgica. Pensiero Scientifico, Roma, pp 47–62Google Scholar
  7. 7.
    Genio Genio A Del, Martino N di, Amato G, Fei L, Pezzullo A (1979) pH-metria esofagea: registrazione di lunga durata. Atti Soc Ital Chir 2:1049–1051Google Scholar
  8. 8.
    Genio A Del, Fei L, Amato G, Martino N di, Izzo G, Landolfì V (1981) La pH-metria esofagea di lunga durata nella nostra esperienza. Riforma Med 96:619–624Google Scholar
  9. 9.
    Genio A Del, Fei L, Martino N di, Landolfì V, Izzo G (1981) Sull’impiego della pH-metria combinata nello studio dell’esofagite da reflusso. Arch Atti Soc Ital Chir 203–204Google Scholar
  10. 10.
    Genio A Del, Fei L, Martino N di, Maffettone V (1985) Experience with combined esophagogastric monitoring. In: DeMeester TR (ed) Esophageal disorders: pathophysiology and therapy. Raven, New York, pp 621–633Google Scholar
  11. 11.
    Genio A Del, Pignatelli C, Chiariello L, Maffettone F, Califano G (1968) L’elettromanome-tria nello studio della funzione motoria dell’esofago. Rass Med Sperim [Suppl 4] 15:58–81Google Scholar
  12. 12.
    Genio A Del, Zarilli L, Chiariello L, Maffettone F, Abate S (1970) Alterazioni esofagee nella sclerosi sistemica progressiva (sclerodermia). Rass Med Sperim 17:60–88Google Scholar
  13. 13.
    Dimarino AJ, Carloson G, Mayers S, Schumacher HR, Cohen S (1973) Duodenal myoelectric activity in scleroderma. N Engl J Med 289:1220–1223PubMedCrossRefGoogle Scholar
  14. 14.
    Martino N Di, Amato G, Fei L, Izzo G, Pricolo R, Genio A del (1979) Il ruolo della elettromanometria nello studio delle alterazioni esofagee in soggetti affetti da collagenopatie. Panorama Sanitario 2:153–156Google Scholar
  15. 15.
    Martino N Di, Fei L, Amata G, Pricolo R, Genio A del (1981) L’elettromanometria esofagea nello studio delle collagenopatie. In: Mattioli GP (ed) Manometria e pH-metria esofagea. Piccin, Padova, pp 203–208Google Scholar
  16. 16.
    Ehrmann S (1903) Über die Beziehung der Sklerodermie zu den autotoxischen Erythemen. Wien Med Wochenschr 53:1097–1110Google Scholar
  17. 17.
    Fei L, Ambrosio A, Martino N di, Amato G, Landolfì V, Cosenza A, Genio A del (1985) La pH-metria combinata gastrica ed esofagea computerizzata (Abstr). 3rd National Congress „Le complicanze in chirurgia: aspetti medico chirurgici”, NaplesGoogle Scholar
  18. 18.
    Fei L, Martino N di, Amato G, Landolfì V, Ambrosio A, Cosenza A, Genio A del (1986) La pH-metria combinata esofago-gastrica di lunga durata (24 ore) nello studio dei pazienti sclerodermici. Minerva Med 77:441–446PubMedGoogle Scholar
  19. 19.
    Garret JM, Winkelmann RK, Schlegel JF, Code CF (1971) Esophageal deterioration in scleroderma. Mayo Clinic Proc 46:92–98Google Scholar
  20. 20.
    Gintrac E (1847) Note sur la sclérodermie. Rev Med Chir 2:263–275Google Scholar
  21. 21.
    Giordano M (1973) La sclerosi sistemica progressiva. Riforma Med 86:1813–1821Google Scholar
  22. 22.
    Giordano M (1977) La sclerosi sistemica progressiva. Pozzi, RomeGoogle Scholar
  23. 23.
    Giordano M, Ara M, Capelli L, Tirri G, Vatti M (1976) Über die Vielseitigkeit und die Einstufung der klinischen Bilder der progredienten generalisierten Sklerodermie. Z Rheumatol 35:286–298PubMedGoogle Scholar
  24. 24.
    Goetz RH (1945) The pathology of progressive systemic sclerosis (generalized scleroderma) with special reference to changes in viscera. Clin Proc 4:337–348Google Scholar
  25. 25.
    Gosselin A (1985) Motricité oesophagienne, sclérodermie systémique et phénomène de Raynaud. Gastroenterol Clin Biol 9:127–129PubMedGoogle Scholar
  26. 26.
    Hamel-Roy J, Devroede G, Arhan P, Tetreault L, Duranceau A, Menard HA (1985) Comparative esophageal and anorectal motility in scleroderma. Gastroenterology 88:1–7PubMedGoogle Scholar
  27. 27.
    Henderson RD, Mugash FL, Jeejeebhoy KM, Szczpanski MM, Cullen J, Marryatt G, Boszka A (1972) The role of bile and acid in the production of esophagitis and the motor defect of esophagitis. Ann Thorac Surg 14:465–472PubMedCrossRefGoogle Scholar
  28. 28.
    Hostein J, Bost R, Carpentier P, Franco A, Faurnet J (1985) Motricité oesophagienne au course de la maladie de Raynaud, de la sclérodermie systémique et du syndrome de Raynaud présclérodermique. Gastroenterol Clin Biol 9:130–135PubMedGoogle Scholar
  29. 29.
    Johnson L, DeMeester TR (1974) Twenty four hour pH-monitoring of the distal esophagus. A quantitative measure of gastro-esophageal reflux. Am J Gastroenterol 62:325–332PubMedGoogle Scholar
  30. 30.
    Kraus EJ (1924) Zur Pathogenese der diffusen Sklerodermie. Zugleich ein Beitrag zur Pathologie der Epithelkörperchen. Virchows Arch Pathol Anat 253:710–725CrossRefGoogle Scholar
  31. 31.
    Lanzara A (1984) Discinesie esofagee. Arch Atti Soc Ital Chir 585–595Google Scholar
  32. 32.
    Little AG, Martinez EI, DeMeester TR, Blough RM, Skinner DB (1984) Duodenogastric reflux and reflux esophagitis. Surgery 96:447–454PubMedGoogle Scholar
  33. 33.
    Matheis A (1976) Atti del Symposio Austro-Italo-Tedesco sulla Sclerosi Sistemica Progressiva, Venice, May 27–30Google Scholar
  34. 34.
    Matikainen M, Taavitsainen M, Kalima TV (1981) Duodeno-gastric reflux in patients with heartburn and esophagitis. Scand J Gastroenterol 16:253–261PubMedCrossRefGoogle Scholar
  35. 35.
    O’Leary PA, Normland R (1930) A clinical study of one hundred and three cases of scleroderma. Am J Med Sci 180:95–102CrossRefGoogle Scholar
  36. 36.
    Pisani M, del Genio A (1984) Alterazioni esofagee nella sclerodermia. G Ital Dermatol Venereol 119:281–286PubMedGoogle Scholar
  37. 37.
    Poirer JJ, Rankin GB (1972) Gastrointestinal manifestations of progressive systemic scleroderma based on a review of 364 cases. Am J Gastroenterol 58:30–44Google Scholar
  38. 38.
    Rake G (1931) On the pathology and pathogenesis of scleroderma. Bull Johns Hopkins Hosp 48:212–221Google Scholar
  39. 39.
    Ribuffo A (1976) Atti del Symposio Austro-Italo-Tedesco sulla Sclerosi Sistemica Progressiva, Venice, May 27–30Google Scholar
  40. 40.
    Skinner DB (1985) Pathophysiology of gastroesophageal reflux. Ann Surg 202:546–556PubMedCrossRefGoogle Scholar
  41. 41.
    Winans CS, Harris LD (1967) Quantitation of lower esophageal sphincter competence. Gastroenterology 52:773–778PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • N. Di Martino
    • 1
  • G. Amato
    • 1
  • L. Feil
    • 1
  • G. Izzo
    • 1
  • V. Maffettone
    • 1
  • A. Cosenza
    • 1
  • F. Donati
    • 1
  • A. Del Genio
    • 1
  1. 1.Gastrointestinal Surgery Unit, Institute of General Surgery and Surgical Therapy, 1st Faculty of Medicine and SurgeryUniversity of NaplesNaplesItaly

Personalised recommendations