Zusammenfassung
In den letzten Jahren hat die Immunologie des Insulins eine überraschende Bedeutung gewonnen. Eine große Zahl bisher unerklärlicher Phänomene lassen sich nunmehr verstehen. Wir müssen sie nicht mehr als isolierte Erscheinungen der Antigenwirkung des Insulins ansehen. Sie finden ihren Platz in dem großen Gebäude der modernen Immunbiologie.
Die diesem Vortrag zugrunde liegenden eigenen Untersuchungen erfolgten mit Unterstützung der Deutschen Forschungsgemeinschaft, Bad Godesberg
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Literatur
Ammon, J., F. Melani und U. Gröschel-Stewart: Nachweis von immunologisch hemmbarer Insulinaktivität bei Schnecken (Helix pomatia L). 2. Tgg. Dtsch. Diab. Ges., Wiesbaden 1966.
Arquilla, E. K., J. D. Alexander, D. Ptacek, and S. Loosli: Studies on Insulin Neutralization by Antisera from Various Species I. Methodology and Assay of Insulin with Intact Anesthetized Rats. Diabetes, 1962, II, No. 5, 412.
D. Ptacek, and S. Loosli —, and J. Finn: Insulin Antibody Variations in Rabbits and Guinea Pigs and Multiple Anti-genetic Determinants of Insulin. J. exp. Med. 118, 55 (1963).
Attardi, G., M. Cohn, J. Hosibata, and E. S. Lennox: Antibody formation by rabbit lymph node cells I.-IV. J. Immunol. 92, 335, 346, 356, 372 (1964).
Baney, R. N., J. J. Vazquez, and F. J. Dixon: Cellular proliferation in relation to antibody synthesis. Proc. Soc. exp. Biol. (N. Y.) 109, 1 (1962).
Berson, S. A., and R. S. Yalow: Insulinantigonists, Insulinantibodies and Insulinresistance. Amer. J. Med. 30, 155 (1958).
— — Species-specificity of human anti-beef, anti-pork insulin serum. J. clin. Invest. 38, 2017 (1959).
— — Quantitative aspects of the reaction between insulin and insulin-binding antibody. J. clin. Invest. 39, 1996 (1960).
— — Antigens in Insulin: Determinants of specificity of porcine insulin in man. Science 159, 844 (1963).
— —, A. Bauman, M. A. Rothschild, and K. Newerly: Metabolism of Insulin — I131 in man. J. clin. Invest. 35, 170 (1956).
Brunfeldt, K., and T. Deckert: The antigenetic properties of pig insulin. Acta endocr. (Kbh.) 47, 353 (1964).
Burrows, B. A., Th. Peters, and F. C. Lowell: Physical Binding of Insulin by Globulins of Insulin-Resistant Subjects. J. clin. Invest. 36, I, 393 (1957).
Chase, M. W.: Delayed sensitivity. Med. Clin. N. Amer. 1965, 1613.
Davidson, J. K., and E. E. Eddleman: Insulin resistance; review of literature and report of case associated with carcinoma of pancreas. Arch. intern. Med. 1950, 86, 727.
Deckert, T.: Autoimmunity and Diabetes. Abstr. Coll. on Immunology of Insulin, London, Sept. 1965.
Dienes, u. Schoenheit (1927) zit. bei
Dienes, L.: The first manifestation of the developing hypersensitiveness. Proc. Soc. exp. Biol. (N. Y.) 28, 75 (1930).
Dixon, G. H.: Recombination of insulin A and B chains, hybrid insulins and synthetic insulin. Proc. 2nd. Intern. Congr. Endocrinol. London 1964, Int. Congr. Ser. Nr. 83, p. 1207, Exerpta med. (Amst.).
Dutton, R. W.: Importance of cell division for antibody production in an in vitro system. Nature (Lond.) 192, 462 (1961).
Falkmer, S., and S. Wilson: Comparative immunology of insulin. Abstr. Coll. on Immunology of Insulin. London, Sept. 1965.
Federlin, K., G. Heinemann, I. Gigli und H. Ditschuneit: Antigenbindung durch zirkulierende Leukozyten bei der verzögerten lokalen Insulinallergie. Dtsch. med. Wschr. 1966.
Fenton, E. L., C. B. Mann, G. G. Pope, and G. H. Smith: The Production of Circulating Auto-Antibodies to Guinea-Pig Insulin. Abstr. Program Autumn Meeting of Med. a. Scient. Sect. of Brit. Diab. Assoc, 1963.
Garvin, J. E.: Factors affecting the adhesiveness of human leucocytes and platelets in vitro. J. exp. Med. 114, 51 (1961).
Gepts, W.: Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus. Diabetes, 14, 619 (1965).
Grodsky, G. M.: Production of auto-antibodies to insulin in man and rabbits. Diabetes, 14, 396 (1965).
Harris, T. N.: Cellular Sources of Antibody: A review of recent developments. Med. Clin. N. Amer. 49, No. 6, 1517 (1965).
—, and S. Harris: Cellular Sources of Antibody: A review of current literature. Amer. N. Y. Acad. Sci. 86, 948 (1960).
Heremans, J. F., and J. P. Vaerman: α-2A-Globulin as a possible carrier of allergic reaginic activity. Nature (Lond) 193, 1091 (1962).
Hughes-Jones, N. C.: Nature of the reactions between antigen and antibody. Brit. med. Bull. 19, 171 (1963).
Jerne, N. E., and A. A. Nordin: Plaque formation in agar by single antibody producing cells. Science 140, 405 (1963).
Jones, T. D., and J. R. Mote: Phases of foreign protein sensitization in human beings. New Engl. J. Med. 210, 120 (1934).
Kalant, N., C. Gomberg, and R. Schreiber: The effect of insulin binding antibodies on insulin sensitivity. Lancet 1958, II, 614.
Kerp, L., S. Steinhilber, F. Reeling und W. Creutzfeldt: Klinische und experimentelle Untersuchungen zur Insulinallergie und Insulinresistenz. Dtsch. med. Wschr. 90, 806 (1965).
Lacy, P. E., and P. H. Wright: Allergic interstitial pancreatitis in rats injected with guinea pig anti-insulin serum. Diabetes 14, 634 (1965).
Lapresle, C.: Etude de la dégradation de la serumalbumine humaine par un extrait de rate du lapin. II. Mise en évidence de trois groupements spécifiques différents dans le motif antigenique de l’albumine humaine et de trois anticorps correspondants dans le serum de lapin antialbumine humaine. Ann. Inst. Pasteur 89, 654 (1955).
Le Compte, P. M.: „Insulitis“ in early juvenile diabetes. Arch Path. 66, 450 (1958).
Lockwood, D. H., and T. E. Prout: Isoantibodies to insulin. Clin. Res. 10, 401 (1962).
Loveless, M. H., and J. R. Cann: Distribution of allergic and blocking activity in human serum protein fractionated by electrophoretic convection. Science 17, 105 (1953).
Lowell, F. C.: Evidence for the existence of low antibodies for crystalline insulin. Proc. Soc. exp. Biol. (N. Y.) 49, 167 (1942).
Lowell, F., and W. Franklin: Induced insulin resistance in rabbit. J. clin. Invest. 28, 199 (1949).
Mann, Caroline, B.: Studies on the neutralization of guinea-pig insulin by antibodies to insulin produced in the same species. Abstr. Coll. on Immunol. of Insulin, London, Sept. 1955.
Moloney, P. J.: Endogenous and pancreatic insulins. Ciba Found. Coll. Endocrinol., Vol. 14, p. 169. Immunoassay of Hormones. Wolstenholme, G. E. W., and M. P. Comeron. Ed. London: Churchill 1962.
—, and M. Coval: Antigenicity of insulin: Diabetes induced by specific antibodies. Biochem. J. 59, 179 (1955).
Morcos, R. H., S. Abd El Naby, H. Ditschuneit und E. F. Pfeiffer: Über die Ursache der Insulinresistenz bei der Insulinschocktherapie in der Psychiatrie. Med. Klin. 60, 1073, 1078 (1965).
Nelson, R. A. Jr.: The immun-adherence phenomenon: An immunologically specific reaction between microorganisms and erythrocytes leading to enhanced phagocytosis. Science 118, 733 (1953).
Nossal, G. J. V., and O. Makela: Kinetic studies on the incidence of cells appearing to form two antibodies. J. Immunol. 88, 604 (1962).
—, A. Szenberg, G. L. Ada, and C. M. Austin: Single cell studies on 19 S antibody production. J. exp. Med. 119, 485 (1964).
Oakley, G. W.: Disk. Bem. in Immunology of Insulin. London, Sept. 1965.
Pfeiffer, E. F.: Lack of correlation between immunologic neutralization of biologic action and antigenetic reactivity of certain proteic hormones (insulin, ACTH). In: Euratom-Symposium über „Problems connected with the preparation and use of labelled proteins in Tracer studies“, Pisa, 17.–19.1.1966. J. labelled comp. (In press).
— Acquisitions récentes concernant l’immunologie de l’insuline. Société d’Endocrinologie, Faculté des Sciences, Université de Paris 3. März 1966. (Ann. Endocr. (Paris) (Im Druck).
—, u. J. Beyer: Die Hypoglycämien. In Handbuch des Diabetes mellitus, Pathophysiologie und Klinik, Bd. II. E. F. Pfeiffer. Herausg. München: J. F. Lehmanns Verl. 1966. (Im Druck).
—, u. H. Ditschuneit: Aktuelle Probleme der Diabetestherapie. Dtsch. med. Wschr. 87, 2290 (1962).
Rabinowitz, Y.: Separation of lymphocytes, polymorphonuclear leucocytes on glass columns including tissue observations. Blood 23, 811 (1964).
Renold, A. E.: Immunologic response to homologous and heterologous insulin in cattle and in sheep. Evidence for immune insulinitis in cattle and possibly in sheep. Coll. on Immunol. of Insulin. London, Sept. 1965.
—, J. Steinke, J. S. Soeldner, R. E. Smith, and H. N. Antoniades: Immunologic response of heifers to the administration of porcine and bovine (homologous) insulin. J. clin. Invest. 42, 969 (1963).
Samols, E., and V. Jones: Insulin resistance, and the relationship of human antibodies to insulin when measured by three different methods. 1. Jahresversammlung Europ. Ges. Diabetesforschung. Montecatini, 20.–22. IV. 1965, Abstr. Nr. 16.
Shipp, J. C., R. O. Russell, J. Steinke, M. L. Mitchell, and W. B. Hadley: Insulin Resistance with High Levels of Circulating Insulin-like Activity Demonstrable in Vitro and in Vivo. Diabetes, 10, 1 (1961).
Skom, H. H., and D. W. Talmage: Nonprecipitating Insulin Antibodies. J. clin. Invest. 37, I. 783 (1958).
— — The Role of Nonprecipitating Insulin Antibodies in Diabetes. J. clin. Invest. 37, I. 797 (1958).
Smith, L. F.: Diskussionsbem. anl. Coll. on Immunology of Insulin. London, Sept. 1965 (Im Druck).
Sönksen, P. H., J. P. Ellis, and C. Lowy: Plasmainsulin: A correlation between bioassay and immunoassay. Brit. med. J. 5455, 209 (1965).
Steinke, J., and J. S. Soeldner: Insulin resistance; Differentiation into two types by measurement of serum Insulin-like activity in vitro. Diabetes, 14, 432 (1965).
Toreson, W. E., R. Feldman, J. C. Lee, and G. M. Grodsky: Pathology of diabetes mellitus produced in rabbits by means of immunisation with beef insulin. Amer. J. clin. Path. (Abstr.) 42, 531 (1964).
Volpe, R., J. Evans, D. W. Clarke, N. Forbath, and R. Ehrlich: Evidence favoring the sarcomatous origin of an insulinlike substance in a case of fibrosarcoma with hypoglycemia. Amer. J. Med. 38, 540 (1965).
Weiger, R. W., and A. R. Colwell: The inhibition of insulin action by serum gamma globulin. Clin. Res. Proc. 4, 123 (1956).
Wilson, S., and G. H. Dixon: A Comparison of cod and bovine insulins. Nature (Lond.) 191, 876 (1961).
— —, and A. C. Wardlaw: Resynthesis of cod insulin from its polypeptide chains and the preparation of cod-ox „hybrid“ insulins. Biochim. biophys. Acta (Amst.) 62, 483 (1962).
Yagi, Y., P. Maier, and D. Pressman: Two different anti-insulin antibodies in guinea pig antisera. J. Immunol. 89, 442 (1962).
Yalow, R. S., and S. A. Berson: Immunologie aspects of insulin. Amer. J. Med., 31, 882 (1961).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1967 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Pfeiffer, E.F. (1967). Die Immunologie des Insulins. In: Klein, E. (eds) Die Pathogenese des Diabetes Mellitus. Symposion der Deutschen Gesellschaft für Endokrinologie, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86329-5_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-86329-5_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-03996-9
Online ISBN: 978-3-642-86329-5
eBook Packages: Springer Book Archive