Advertisement

Die Immunologie des Insulins

  • E. F. Pfeiffer
Part of the Symposion der Deutschen Gesellschaft für Endokrinologie book series (ENDOKRINOLOGIE, volume 12)

Zusammenfassung

In den letzten Jahren hat die Immunologie des Insulins eine überraschende Bedeutung gewonnen. Eine große Zahl bisher unerklärlicher Phänomene lassen sich nunmehr verstehen. Wir müssen sie nicht mehr als isolierte Erscheinungen der Antigenwirkung des Insulins ansehen. Sie finden ihren Platz in dem großen Gebäude der modernen Immunbiologie.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Ammon, J., F. Melani und U. Gröschel-Stewart: Nachweis von immunologisch hemmbarer Insulinaktivität bei Schnecken (Helix pomatia L). 2. Tgg. Dtsch. Diab. Ges., Wiesbaden 1966.Google Scholar
  2. Arquilla, E. K., J. D. Alexander, D. Ptacek, and S. Loosli: Studies on Insulin Neutralization by Antisera from Various Species I. Methodology and Assay of Insulin with Intact Anesthetized Rats. Diabetes, 1962, II, No. 5, 412.Google Scholar
  3. D. Ptacek, and S. Loosli —, and J. Finn: Insulin Antibody Variations in Rabbits and Guinea Pigs and Multiple Anti-genetic Determinants of Insulin. J. exp. Med. 118, 55 (1963).PubMedCrossRefGoogle Scholar
  4. Attardi, G., M. Cohn, J. Hosibata, and E. S. Lennox: Antibody formation by rabbit lymph node cells I.-IV. J. Immunol. 92, 335, 346, 356, 372 (1964).PubMedGoogle Scholar
  5. Baney, R. N., J. J. Vazquez, and F. J. Dixon: Cellular proliferation in relation to antibody synthesis. Proc. Soc. exp. Biol. (N. Y.) 109, 1 (1962).Google Scholar
  6. Berson, S. A., and R. S. Yalow: Insulinantigonists, Insulinantibodies and Insulinresistance. Amer. J. Med. 30, 155 (1958).CrossRefGoogle Scholar
  7. — — Species-specificity of human anti-beef, anti-pork insulin serum. J. clin. Invest. 38, 2017 (1959).PubMedCrossRefGoogle Scholar
  8. — — Quantitative aspects of the reaction between insulin and insulin-binding antibody. J. clin. Invest. 39, 1996 (1960).Google Scholar
  9. — — Antigens in Insulin: Determinants of specificity of porcine insulin in man. Science 159, 844 (1963).CrossRefGoogle Scholar
  10. — —, A. Bauman, M. A. Rothschild, and K. Newerly: Metabolism of Insulin — I131 in man. J. clin. Invest. 35, 170 (1956).PubMedCrossRefGoogle Scholar
  11. Brunfeldt, K., and T. Deckert: The antigenetic properties of pig insulin. Acta endocr. (Kbh.) 47, 353 (1964).Google Scholar
  12. Burrows, B. A., Th. Peters, and F. C. Lowell: Physical Binding of Insulin by Globulins of Insulin-Resistant Subjects. J. clin. Invest. 36, I, 393 (1957).PubMedCrossRefGoogle Scholar
  13. Chase, M. W.: Delayed sensitivity. Med. Clin. N. Amer. 1965, 1613.Google Scholar
  14. Davidson, J. K., and E. E. Eddleman: Insulin resistance; review of literature and report of case associated with carcinoma of pancreas. Arch. intern. Med. 1950, 86, 727.CrossRefGoogle Scholar
  15. Deckert, T.: Autoimmunity and Diabetes. Abstr. Coll. on Immunology of Insulin, London, Sept. 1965.Google Scholar
  16. Dienes, u. Schoenheit (1927) zit. beiGoogle Scholar
  17. Dienes, L.: The first manifestation of the developing hypersensitiveness. Proc. Soc. exp. Biol. (N. Y.) 28, 75 (1930).Google Scholar
  18. Dixon, G. H.: Recombination of insulin A and B chains, hybrid insulins and synthetic insulin. Proc. 2nd. Intern. Congr. Endocrinol. London 1964, Int. Congr. Ser. Nr. 83, p. 1207, Exerpta med. (Amst.).Google Scholar
  19. Dutton, R. W.: Importance of cell division for antibody production in an in vitro system. Nature (Lond.) 192, 462 (1961).CrossRefGoogle Scholar
  20. Falkmer, S., and S. Wilson: Comparative immunology of insulin. Abstr. Coll. on Immunology of Insulin. London, Sept. 1965.Google Scholar
  21. Federlin, K., G. Heinemann, I. Gigli und H. Ditschuneit: Antigenbindung durch zirkulierende Leukozyten bei der verzögerten lokalen Insulinallergie. Dtsch. med. Wschr. 1966.Google Scholar
  22. Fenton, E. L., C. B. Mann, G. G. Pope, and G. H. Smith: The Production of Circulating Auto-Antibodies to Guinea-Pig Insulin. Abstr. Program Autumn Meeting of Med. a. Scient. Sect. of Brit. Diab. Assoc, 1963.Google Scholar
  23. Garvin, J. E.: Factors affecting the adhesiveness of human leucocytes and platelets in vitro. J. exp. Med. 114, 51 (1961).PubMedCrossRefGoogle Scholar
  24. Gepts, W.: Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus. Diabetes, 14, 619 (1965).PubMedGoogle Scholar
  25. Grodsky, G. M.: Production of auto-antibodies to insulin in man and rabbits. Diabetes, 14, 396 (1965).PubMedGoogle Scholar
  26. Harris, T. N.: Cellular Sources of Antibody: A review of recent developments. Med. Clin. N. Amer. 49, No. 6, 1517 (1965).PubMedGoogle Scholar
  27. —, and S. Harris: Cellular Sources of Antibody: A review of current literature. Amer. N. Y. Acad. Sci. 86, 948 (1960).CrossRefGoogle Scholar
  28. Heremans, J. F., and J. P. Vaerman: α-2A-Globulin as a possible carrier of allergic reaginic activity. Nature (Lond) 193, 1091 (1962).CrossRefGoogle Scholar
  29. Hughes-Jones, N. C.: Nature of the reactions between antigen and antibody. Brit. med. Bull. 19, 171 (1963).PubMedGoogle Scholar
  30. Jerne, N. E., and A. A. Nordin: Plaque formation in agar by single antibody producing cells. Science 140, 405 (1963).CrossRefGoogle Scholar
  31. Jones, T. D., and J. R. Mote: Phases of foreign protein sensitization in human beings. New Engl. J. Med. 210, 120 (1934).CrossRefGoogle Scholar
  32. Kalant, N., C. Gomberg, and R. Schreiber: The effect of insulin binding antibodies on insulin sensitivity. Lancet 1958, II, 614.CrossRefGoogle Scholar
  33. Kerp, L., S. Steinhilber, F. Reeling und W. Creutzfeldt: Klinische und experimentelle Untersuchungen zur Insulinallergie und Insulinresistenz. Dtsch. med. Wschr. 90, 806 (1965).PubMedCrossRefGoogle Scholar
  34. Lacy, P. E., and P. H. Wright: Allergic interstitial pancreatitis in rats injected with guinea pig anti-insulin serum. Diabetes 14, 634 (1965).PubMedGoogle Scholar
  35. Lapresle, C.: Etude de la dégradation de la serumalbumine humaine par un extrait de rate du lapin. II. Mise en évidence de trois groupements spécifiques différents dans le motif antigenique de l’albumine humaine et de trois anticorps correspondants dans le serum de lapin antialbumine humaine. Ann. Inst. Pasteur 89, 654 (1955).Google Scholar
  36. Le Compte, P. M.: „Insulitis“ in early juvenile diabetes. Arch Path. 66, 450 (1958).Google Scholar
  37. Lockwood, D. H., and T. E. Prout: Isoantibodies to insulin. Clin. Res. 10, 401 (1962).Google Scholar
  38. Loveless, M. H., and J. R. Cann: Distribution of allergic and blocking activity in human serum protein fractionated by electrophoretic convection. Science 17, 105 (1953).CrossRefGoogle Scholar
  39. Lowell, F. C.: Evidence for the existence of low antibodies for crystalline insulin. Proc. Soc. exp. Biol. (N. Y.) 49, 167 (1942).Google Scholar
  40. Lowell, F., and W. Franklin: Induced insulin resistance in rabbit. J. clin. Invest. 28, 199 (1949).CrossRefGoogle Scholar
  41. Mann, Caroline, B.: Studies on the neutralization of guinea-pig insulin by antibodies to insulin produced in the same species. Abstr. Coll. on Immunol. of Insulin, London, Sept. 1955.Google Scholar
  42. Moloney, P. J.: Endogenous and pancreatic insulins. Ciba Found. Coll. Endocrinol., Vol. 14, p. 169. Immunoassay of Hormones. Wolstenholme, G. E. W., and M. P. Comeron. Ed. London: Churchill 1962.Google Scholar
  43. —, and M. Coval: Antigenicity of insulin: Diabetes induced by specific antibodies. Biochem. J. 59, 179 (1955).PubMedGoogle Scholar
  44. Morcos, R. H., S. Abd El Naby, H. Ditschuneit und E. F. Pfeiffer: Über die Ursache der Insulinresistenz bei der Insulinschocktherapie in der Psychiatrie. Med. Klin. 60, 1073, 1078 (1965).PubMedGoogle Scholar
  45. Nelson, R. A. Jr.: The immun-adherence phenomenon: An immunologically specific reaction between microorganisms and erythrocytes leading to enhanced phagocytosis. Science 118, 733 (1953).PubMedCrossRefGoogle Scholar
  46. Nossal, G. J. V., and O. Makela: Kinetic studies on the incidence of cells appearing to form two antibodies. J. Immunol. 88, 604 (1962).PubMedGoogle Scholar
  47. —, A. Szenberg, G. L. Ada, and C. M. Austin: Single cell studies on 19 S antibody production. J. exp. Med. 119, 485 (1964).PubMedCrossRefGoogle Scholar
  48. Oakley, G. W.: Disk. Bem. in Immunology of Insulin. London, Sept. 1965.Google Scholar
  49. Pfeiffer, E. F.: Lack of correlation between immunologic neutralization of biologic action and antigenetic reactivity of certain proteic hormones (insulin, ACTH). In: Euratom-Symposium über „Problems connected with the preparation and use of labelled proteins in Tracer studies“, Pisa, 17.–19.1.1966. J. labelled comp. (In press).Google Scholar
  50. — Acquisitions récentes concernant l’immunologie de l’insuline. Société d’Endocrinologie, Faculté des Sciences, Université de Paris 3. März 1966. (Ann. Endocr. (Paris) (Im Druck).Google Scholar
  51. —, u. J. Beyer: Die Hypoglycämien. In Handbuch des Diabetes mellitus, Pathophysiologie und Klinik, Bd. II. E. F. Pfeiffer. Herausg. München: J. F. Lehmanns Verl. 1966. (Im Druck).Google Scholar
  52. —, u. H. Ditschuneit: Aktuelle Probleme der Diabetestherapie. Dtsch. med. Wschr. 87, 2290 (1962).PubMedCrossRefGoogle Scholar
  53. Rabinowitz, Y.: Separation of lymphocytes, polymorphonuclear leucocytes on glass columns including tissue observations. Blood 23, 811 (1964).PubMedGoogle Scholar
  54. Renold, A. E.: Immunologic response to homologous and heterologous insulin in cattle and in sheep. Evidence for immune insulinitis in cattle and possibly in sheep. Coll. on Immunol. of Insulin. London, Sept. 1965.Google Scholar
  55. —, J. Steinke, J. S. Soeldner, R. E. Smith, and H. N. Antoniades: Immunologic response of heifers to the administration of porcine and bovine (homologous) insulin. J. clin. Invest. 42, 969 (1963).Google Scholar
  56. Samols, E., and V. Jones: Insulin resistance, and the relationship of human antibodies to insulin when measured by three different methods. 1. Jahresversammlung Europ. Ges. Diabetesforschung. Montecatini, 20.–22. IV. 1965, Abstr. Nr. 16.Google Scholar
  57. Shipp, J. C., R. O. Russell, J. Steinke, M. L. Mitchell, and W. B. Hadley: Insulin Resistance with High Levels of Circulating Insulin-like Activity Demonstrable in Vitro and in Vivo. Diabetes, 10, 1 (1961).Google Scholar
  58. Skom, H. H., and D. W. Talmage: Nonprecipitating Insulin Antibodies. J. clin. Invest. 37, I. 783 (1958).PubMedCrossRefGoogle Scholar
  59. — — The Role of Nonprecipitating Insulin Antibodies in Diabetes. J. clin. Invest. 37, I. 797 (1958).Google Scholar
  60. Smith, L. F.: Diskussionsbem. anl. Coll. on Immunology of Insulin. London, Sept. 1965 (Im Druck).Google Scholar
  61. Sönksen, P. H., J. P. Ellis, and C. Lowy: Plasmainsulin: A correlation between bioassay and immunoassay. Brit. med. J. 5455, 209 (1965).CrossRefGoogle Scholar
  62. Steinke, J., and J. S. Soeldner: Insulin resistance; Differentiation into two types by measurement of serum Insulin-like activity in vitro. Diabetes, 14, 432 (1965).PubMedGoogle Scholar
  63. Toreson, W. E., R. Feldman, J. C. Lee, and G. M. Grodsky: Pathology of diabetes mellitus produced in rabbits by means of immunisation with beef insulin. Amer. J. clin. Path. (Abstr.) 42, 531 (1964).Google Scholar
  64. Volpe, R., J. Evans, D. W. Clarke, N. Forbath, and R. Ehrlich: Evidence favoring the sarcomatous origin of an insulinlike substance in a case of fibrosarcoma with hypoglycemia. Amer. J. Med. 38, 540 (1965).PubMedCrossRefGoogle Scholar
  65. Weiger, R. W., and A. R. Colwell: The inhibition of insulin action by serum gamma globulin. Clin. Res. Proc. 4, 123 (1956).Google Scholar
  66. Wilson, S., and G. H. Dixon: A Comparison of cod and bovine insulins. Nature (Lond.) 191, 876 (1961).CrossRefGoogle Scholar
  67. — —, and A. C. Wardlaw: Resynthesis of cod insulin from its polypeptide chains and the preparation of cod-ox „hybrid“ insulins. Biochim. biophys. Acta (Amst.) 62, 483 (1962).CrossRefGoogle Scholar
  68. Yagi, Y., P. Maier, and D. Pressman: Two different anti-insulin antibodies in guinea pig antisera. J. Immunol. 89, 442 (1962).PubMedGoogle Scholar
  69. Yalow, R. S., and S. A. Berson: Immunologie aspects of insulin. Amer. J. Med., 31, 882 (1961).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

  • E. F. Pfeiffer
    • 1
  1. 1.Abteilung für Klinische Endokrinologie der I. Med. KlinikJohann Wolfgang Goethe-UniversitätFrankfurt am MainDeutschland

Personalised recommendations