Die Wirkung des Insulins am Fettgewebe

  • B. Jeanrenaud
  • W. Stauffacher
Part of the Symposion der Deutschen Gesellschaft für Endokrinologie book series (ENDOKRINOLOGIE, volume 12)

Zusammenfassung

Das Insulin ist ein anaboles Hormon, das die Aufnahme, die Synthese oder aber die Speicherung von Stoffen wie Kohlenhydraten, Fetten und Eiweißen fördert. Diese generelle anabole Wirkung des Hormons kommt auch im Fettgewebe zum Ausdruck, und zwar in zweifacher Hinsicht. Insulin stimuliert einerseits die Fettsynthese und vermindert anderseits die Lipolyse, d. h. die hydrolytische Spaltung von Triglyceriden in Fettsäuren und Glycerin. Seine Wirkung auf die synthetischen Vorgänge im Fettgewebe wird in Abb. 1 zusammenfassend dargestellt: die durch Insulin bewirkte Stimulation der Glucoseaufnahme drückt sich in einer Zunahme der Inkorporation von markiertem Kohlenstoff in alle untersuchten Stoffwechselprodukte aus, darunter auch in die Lipide.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1).
    Di Pietro, D. L.: Hexokinase of white adipose tissue. Biochim. biophys. Acta (Amst.) 67, 305 (1963).CrossRefGoogle Scholar
  2. 2).
    Levine, R., and M. S. Goldstein: On the Mechanism of Action of Insulin. Recent Progr. Hormone Res. 11, 343 (1955).Google Scholar
  3. 3).
    Park, C. R., D. Reinwein, M. J. Henderson, E. Cadenas, and H. E. Morgan: The Action of Insulin on the Transport of Glucose through the Cell-membrane. Amer. J. Med. 26, 674 (1959).PubMedCrossRefGoogle Scholar
  4. 4).
    Rändle, P. J., and F. G. Young: The Mechanism of Action of Insulin. Brit. med. Bull. 16, 237 (1960).PubMedGoogle Scholar
  5. 5).
    Fisher, R. B., and P. Zachariah: The Mechanism of the Uptake of Sugars by the Rat Heart and the Action of Insulin on this mechanism. J. Physiol. (Lond.) 158, 73 (1961).Google Scholar
  6. 6).
    Morgan, H. E., D. M. Regen, and C. R. Park: Identification of a mobile Carrier-mediated Sugar Transport System in Muscle. J. biol. Chem. 239, 369 (1964).PubMedGoogle Scholar
  7. 7).
    Crofford, O. B., and A. E. Renold: Glucose Uptake by Incubated Rat Epididymal adipose tissue. Rate limiting steps and Site of Insulin Action. J. biol. Chem. 240, 14 (1965).PubMedGoogle Scholar
  8. 8).
    — — Glucose Uptake by Incubated Rat Epididymal adipose tissue. Characteristics of the Glucose Transport System and Action of Insulin. J. biol. Chem. 240, 3237 (1965).PubMedGoogle Scholar
  9. 9).
    Heckmann, K.: Die Permeabilität Biologischer Membranen. In Mechanisms of Hormone Action, A Nato Advanced Study Institute. Karlson, P. (Ed.) Stuttgart: Thieme. New York and London: Academic Press 1965.Google Scholar
  10. 10).
    Perry, W. F., and H. F. Bowen: Factors affecting the in-vitro production of non-esterified fatty acids from adipose tissue. Canad. J. Biochim. 40, 749 (1962).CrossRefGoogle Scholar
  11. 11).
    Jungas, R. L., and E. G. Ball: Studies on the Metabolism of adipose Tissue. XII: The Effects of Insulin and Epinephrine on Free Fatty and Glycerol Production in the Presence and Absence of Glucose. Biochemistry 2, 383 (1963).CrossRefGoogle Scholar
  12. 12).
    Mahler, R., W. S. Stafford, M. E. Tarrant, and J. Ashmore: The Effect of Insulin on Lipolysis. Diabetes 13, 297 (1964).PubMedGoogle Scholar
  13. 13).
    Froesch, E. R., H. Bürgi, P. Bally, and A. Labhart: Insulin Inhibition of Spontaneous Adipose Tissue Lipolysis and Effects upon Fructose and Glucose Metabolism. Mol. Pharmacol. 1, 280 (1965).PubMedGoogle Scholar
  14. 14).
    Goodman, H. M.: Stimulatory Action of Insulin on Leucine Uptake and Metabolism in Adipose Tissue. Amer. J. Physiol. 206, 129 (1964).PubMedGoogle Scholar
  15. 15).
    Krahl, M. E.: Incorporation of 14C amino acid precursors into adipose tissue protein: an Insulin stimulation not involving glucose or amino acid transport. Biochim. biophys. Acta (Amst.) 35, 556 (1959).CrossRefGoogle Scholar
  16. 16).
    Carruthers, B. M., and A. I. Winegrad: Effects of insulin on amino acid and ribonucleic acid metabolism in rat adipose tissue. Amer. J. Physiol. 202, 605 (1962).PubMedGoogle Scholar
  17. 17).
    Krahl, M. E.: Stimulation of peptide synthesis in adipose tissue by insulin without glucose. Amer. J. Physiol. 206, 618 (1964).PubMedGoogle Scholar
  18. 18).
    Gourley, D. R. H., and M. D. Bethea: Insulin effect on adipose tissue sodium and potassium. Proc. exp. Biol. Soc. (N.Y.) 115, 821 (1964).Google Scholar
  19. 19).
    Beigelman, P. M., and P. B. Hollander: Effects of Hormones upon adipose tissue membrane electrical potentials. Proc. Soc. exp. Biol. (N.Y.) 116, 31 (1964).Google Scholar
  20. 20).
    Barnett, R., and E. G. Ball: Metabolic and ultrastructural changes induced in adipose tissue by insulin. J. biophys. biochem. Cytol. 8, 83 (1960).CrossRefGoogle Scholar
  21. 21).
    Rodbell, M.: Metabolism of isolated fat cells. II. The similar effects of Phospholipase C (Clostridium perfringens α-Toxin) and of insulin on glucose and amino acid metabolism J. biol. Chem. 241, 130 (1966).PubMedGoogle Scholar
  22. 22).
    —, and A. B. Jones: Metabolism of isolated fat cells. III. The similar inhibitory action of Phospholipase C (Clostridium perfringens α-Toxin) and of insulin on lipolysis stimulated by lipolytic hormones and Theophylline. J. biol. Chem. 241, 140 (1966).PubMedGoogle Scholar
  23. 23).
    Autor, A., and W. S. Lynn: Insulin activity in isolated fat cells which are completely permeable to glucose. Biochem. biophys. Res. Commun. 17, 80 (1964).CrossRefGoogle Scholar
  24. 24).
    Crofford, O. B., W. Stauffacher, B. Jeanrenaud, and A. E. Renold: Glucose Transport in isolated Fat Cells: Procedures for Measurement of the Intracellular Water Space. Helv. physiol. pharmacol. Acta 24, 45 (1966).PubMedGoogle Scholar
  25. 25).
    Sutherland, E. W., I. Øye, and R. W. Butcher: The Action of Epinephrine and the Role of the Adenyl Cyclase system in Hormone Action. Recent Progr. Hormone Res. 21, 623 (1965).PubMedGoogle Scholar
  26. 26).
    Rieser, P., and C. Rieser: Insulin catalyzed Proteolysis. Biochem. biophys. Res. Commun. 17, 373 (1964).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

  • B. Jeanrenaud
    • 1
  • W. Stauffacher
    • 1
  1. 1.Institut für klinische BiochemieUniversität GenfSchweiz

Personalised recommendations