Abstract
The discovery, announced simultaneously by the laboratory of Dr. Pastan (1) and by ourselves (2) of profound change in cell habitus produced by dibutyryl cyclic AMP, appears to hold important implications for the field of cellular interactions generally and the nature of malignancy specifically. The reaction under consideration here resembles in many respects the changes produced when a cell is transformed to malignancy by an oncogenic virus or chemical agent. However, in contrast to the irreversible nature of the latter set of changes, that produced by cyclic AMP is completely reversible. It thus appears to furnish an ideal tool for study of the molecular nature of the underlying effects.
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References
Johnson, G. S., Friedman, R. M., and Pastan, I. “Restoration of Several Morphological Characteristics of Normal Fibroblasts in Sarcoma Cells Treated with Adenosine 3′,5′-Cyclic Monophosphate and Its Derivatives,” Proc. Nat. Acad. Sci. (U.S.A.) 68:425–429 (1971).
Hsie, A. W., and Puck, T. T. “Morphological Transformation of Chinese Hamster Cells by Dibutyryl Adenosine Cyclic 3′,5′-Monophosphate and Testosterone,” Proc. Nat. Acad. Sci. (U.S.A.) 68:358–361 (1971).
Hsie, A. W., Jones, C., and Puck, T. T. “Further Changes in Differentiation State Accompanying the Conversion of Chinese Hamster Cells to Fibroblastic Form by Dibutyryl Adenosine Cyclic 3′,5′-Monophosphate and Hormones,” Proc. Nat. Acad. Sci. (U.S.A.) 68:1648–1652 (1971).
Puck, T. T., Waldren, C. A., and Hsie, A. W. “Membrane Dynamics in the Action of Dibutyryl Adenosine 3′,5′-Cyclic Monophosphate and Testosterone on Mammalian Cells,” Proc. Nat. Acad. Sci. (U.S.A.) 69:1943–1947 (1972).
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© 1974 Springer-Verlag Berlin Heidelberg
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Puck, T.T., Jones, C. (1974). Cyclic AMP and Microtubular Dynamics in Cultured Mammalian Cells. In: Braun, W., Lichtenstein, L.M., Parker, C.W. (eds) Cyclic AMP, Cell Growth, and the Immune Response. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86026-3_28
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DOI: https://doi.org/10.1007/978-3-642-86026-3_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-86028-7
Online ISBN: 978-3-642-86026-3
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