Cyclic AMP and Microtubular Dynamics in Cultured Mammalian Cells
The discovery, announced simultaneously by the laboratory of Dr. Pastan (1) and by ourselves (2) of profound change in cell habitus produced by dibutyryl cyclic AMP, appears to hold important implications for the field of cellular interactions generally and the nature of malignancy specifically. The reaction under consideration here resembles in many respects the changes produced when a cell is transformed to malignancy by an oncogenic virus or chemical agent. However, in contrast to the irreversible nature of the latter set of changes, that produced by cyclic AMP is completely reversible. It thus appears to furnish an ideal tool for study of the molecular nature of the underlying effects.
KeywordsProgesterone Estradiol Aldosterone Corticosterone Monophosphate
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