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Cyclic AMP, Cell Growth, and the Immune Response pp 302–316Cite as

Control of Normal Cell Proliferation in Vivo and in Vitro by Agents that Use Cyclic AMP as their Mediator

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Abstract

Over the past several years, while the mechanism whereby the hormones of the thyro-parathyroid complex control calcium metabolism in their classical target organs (bone and kidney) has been under intense investigation (1), another role for these hormones has been emerging. It can now be clearly shown that these hormones, parathyroid hormone and calcitonin, intimately control cell proliferation in bone marrow (13, 19–23,31), thymus (8,9,13,18,19,31), and liver (24,31). This retrospective report will give some indication of the physiological importance of this control by the calcium homeostatic system (31). Then two in vitro models will be discussed. Finally, our thoughts on the mechanism whereby cell proliferation is controlled will be presented.

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Authors
  1. J. P. MacManus
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  2. J. F. Whitfield
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  3. R. H. Rixon
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Editor information

Editors and Affiliations

  1. Department of Medicine, The Johns Hopkins University School of Medicine at The Good Samaritan Hospital, Baltimore, Maryland, 21239, USA

    Lawrence M. Lichtenstein

  2. Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Charles W. Parker

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© 1974 Springer-Verlag Berlin Heidelberg

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MacManus, J.P., Whitfield, J.F., Rixon, R.H. (1974). Control of Normal Cell Proliferation in Vivo and in Vitro by Agents that Use Cyclic AMP as their Mediator. In: Braun, W., Lichtenstein, L.M., Parker, C.W. (eds) Cyclic AMP, Cell Growth, and the Immune Response. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86026-3_25

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  • DOI: https://doi.org/10.1007/978-3-642-86026-3_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-86028-7

  • Online ISBN: 978-3-642-86026-3

  • eBook Packages: Springer Book Archive

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