Abstract
We wish to report here on the possible role of cAMP in chemotaxis of leukocytes (leukotaxis). Chemotaxis of leukoytes is a cell-stimulatory process by which chemical changes in the environment are recognized. As a consequence of this cellular recognition process, the cell changes its migratory behavior from random to directional locomotion along a positive concentration gradient (Wissler et al., 1972a; Sorkin et al., 1970) without changing the speed of migration (Carruthers, 1966, 1967; Ramsey 1972a, b). Chemotactic responses are shown by phagocytes— neutrophils, eosinophils, and macrophages (for review see Sorkin et al., 1970). Recently, it has also been reported that basophils (Kay and Austen, 1972) and lymphocytes (Ward et al., 1971) give a chemotactic response. It is likely that other tissue cells, like mast cells, histiocytes, etc., show chemotaxis, but the lack of suitable assay systems restricts our knowledge of their chemotactic response. In view of the possible fundamental importance of tactic reactions (chemotaxis, osmotaxis, thermotaxis, phototaxis, aerotaxis) for the development, differentiation, organization, and behavior of living cells, we would like to regard leukotaxis as a model system for many kinds of recognition phenomena.
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References
Becker, E. L. “Biochemical Aspects of the Polymorphonuclear Response to Chemotactic Factors.” In Biochemistry of the Acute Allergic Reactions, K. F. Austen and E. L. Becker, eds. Oxford: Blackwell Scientific Publications, pp. 243-252 (1971).
Bernauer, W., Hahn, F., Wissler, J., Nimptsch, P. and Filipowski, P. “Untersuchungen mit klassischem und kristalliertem Anaphylatoxin an isolierten Herzpräparaten,” Arch. Pharmakol. Exp. Path. 269:43 (1971).
Bernauer, W., Hahn, F., Nimptsch, P., and Wissler, J. “Studies on Heart Anaphylaxis. V. Cross-Desentization Between Antigen, Anaphylatoxin, and Compound 48/80 in the Guinea Pig Papillary Muscle,” Int. Arch. Allergy 42:136–151 (1972).
Bessis, M., and Burte, B. “Chimiotactisme apres destruction d’une cellule par microfaisceau Laser,” C. R. Soc. Biol. 158:1995 (1964).
Bessis, M., and Burte, B. “Positive and Negative Chemotaxis As Observed After the Destruction of a Cell by UV or Laser Microbeams,” Texas Reports Biol. Med. 23:204 (1965).
Bitensky, M. W., Gorman, R. E., and Miller, W. H. “Adenyl Cyclase As a Link Between Photon Capture and Changes in Membrane Permeability of Frog Photoreceptors,” Proc. Nat. Acad. Sci. (U.S.A.) 68:561–562 (1971).
Bonner, J. T., Barkley, D. S., Hall, E. M., Konijn, T. M., Mason, J. W., O’Keefe, III, G., and Wolfe, P. B. “Acrasin, Acrasinase and Sensitivity to Acrasin in Dictyostelium Discoideum,” Develop. Biol. 20:72 (1969).
Boyden, S. V. “The Chemotactic Effect of Mixtures of Antibody and Antigen on Polymorphonuclear Leucocytes,” J. Exp. Med. 115:453–466 (1962).
Carruthers, B. M. “Leukocyte Motility. I. Method of Study, Normal Variation, Effect of Physical Alterations in Environment, and Effect of Iodoacetate,” Can. J. Physiol. Pharmacol. 44:475–485 (1966).
Carruthers, B. M. “Leukocyte Motility. II. Effect of Absence of Glucose in Medium: Effect of Presence of Deoxyglucose, Dinitrophenol, Puromycin, Actionmycin D, and Trypsin on the Response to Chemotactic Substance; Effect of Segregation of Cells from Chemotactic Substance,” Can. J. Physiol. Pharmacol. 45:269–280 (1967).
Delbrück, M. “Signalwandler: terra incognita der Molekularbiologie,” Angew. Chem. 84:1–7 (1972).
Gerisch, G. Current Topics in Developmental Biology, A. Monroy and A. A. Moscona, eds., Vol. 3. New York: Academic Press, p. 157 (1968).
Green, D. E., and Baum, H. Energy and the Mitrochondrion, New York: Academic Press (1970).
Hatzelbauer, G. L., and Adler, J. “Role of Galactose Binding Protein in Chemotaxis of Escherichia Coli Toward Galactose”, Nature 230:101–104 (1971).
Kaley, G., and Weiner, R. “Effect of Prostaglandin E1 on Leucocyte Migration,” Nature (New Biol.) 234:114–115 (1971).
Kaley, G., and Weiner, R. “Prostaglandin E1. A Potential Mediator of the Inflamatory Response,” Ann. N.Y. Acad. Sci. 180:338–350 (1971).
Katz, B. The Release of Neural Transmitter Substances. Liverpool: University Press (1969).
Katz, B. “Ueber die Freisetzung des Uebertragerstoffs aus den Nerven in Form von Quanten,” Angew. Chem. 83:818–821 (1971).
Kay, A. B., and Austen, K. F. “Chemotaxis of Human Basophil Leucocytes,” Clin. Exp. Immunol. 11:557–563 (1972).
Kishuo, S., Kunisuke, T., Shoji, K., Yoshisuke, K., Hideaki, K., and Shogo, F. Gumna J. Med. Sci. (Japan) 7:91 (1958).
Konijn, T. M., van de Meene, J. G. C., Bonner, J. T., and Barkley, D. S. “The Acrasin Activity of Adenosine 3′,5′-Cyclic Phosphate,” Proc. Nat. Acad. Sci. (U.S.A.) 58:1152–1154 (1967).
Leahy, D. R., McLean, E. R., and Bonner, J. T. “Evidence for Cyclic 3′,5′-Adenosine-Monophosphate As Chemotactic Agent for Polymorphonuclear Leukocytes,” Blood 36:52–54 (1970).
Lichtenstein, L. M. “Characteristics of Leukocytic Histamine Release by Antigen and by Antiimmunoglobulin and Anticellular Antibodies.” In Cellular and Humoral Mechanisms in Anaphylaxis and Allergy, H. Z. Movat, ed. Basel: Karger Verlag, pp. 176-186 (1969).
Lichtenstein, L. M., Levy, D. A., and Ishizaka, K. “In Vitro Reversed Anaphylaxis: Characteristics of Anti-IgE-Mediated Histamine Release,” Immunol. 19:831–842 (1970).
Miller, M. E., Oski, F. A., and Harris, M. B. “Lazy-Leucocyte Syndrome. A New Disorder of Neutrophil Function,” Lancet i:665–669 (1971).
Mustard, J. F., Evans, G., Packham, M. A., and Nishizawa, E. F. “The Platelet in Intravascular Immunological Reactions.” In Cellular and Humoral Mechanisms in Anaphylaxis and Allergy, H. Z. Movat, ed. Basel: Karger Verlag, pp. 157-163 (1969).
Ramsey, W. S. “Analysis of Individual Leukocyte Behavior During Chemotaxis,” Exp. Cell Res. 70:129–139 (1972a).
Ramsey, W. S. “Locomotion of Human Polymorphonuclear Leucocytes,” Exp. Cell Res. 72:489–501 (1972b).
Rifkind, J. M., and Eichhorn, G. L. “Specificity for the Interaction of Nucleotides with Basic Polypeptides,” Biochemistry 9:1753–1761 (1970).
Rossomando, E. F., and Sussman, M. “Adenyl Cyclase in Dictyostelium discoidenum. A Possible Control Element of the Chemotactic System,” Biochem. Biophys. Res. Commun. 47:604–610 (1972).
Sorkin, E., Stecher, V. J., and Borel, J. F. “Chemotaxis of Leukocytes and Inflammation,” Ser. Haematol. III (1) 131–162 (1970).
Sorkin, E., Stecher, V. J., and Wissler, J. H.’ The Anaphylatoxin-Related Leukotactic Binary Peptide System.” In A Reexamination of Nonspecific Factors Influencing Host Resistance. Basel: Karger Verlag (in press— 1972).
Symon, D. N. K., McKay, I. C., and Wilkinson, P. C. “Plasma-Dependent Chemotaxis of Macrophages Toward Mycobacterium tuberculosis and Other Organisms,” Immunol. 22:267–276 (1972).
Ward, P. A., Offen, C. D., and Montgomery, J. R. “Chemoattractants of Leukocytes with Special Reference to Lymphocytes,” Fed. Proc. 30:1721–1724 (1971).
Ward, P. A., and Zvaifler, N. J. “Complement Cleaved Leukotactic Factors in Inflammatory Synovial Fluids of Humans,” J. Clin. Invest. 50:606–616 (1971).
Wilkinson, P. C. “Chemotaxis of Phagocytic Cells Toward Proteins: The Effect of Protein Denaturation.” In The Reticuloendothelial System and Immune Phenomena, N. R. Di Luzio, ed. New York: Plenum Press, pp. 59–70 (1971).
Wilkinson, P. C. “Characterization of the Chemotactic Activity of Casein for Neutrophil Leukocytes and Macrophages,” Experientia 28:1051–1052 (1972).
Wilkinson, P. C. Personal communication (1973).
Wilkinson, P. C., and McKay, I. C. “The Chemotactic Activity of Native and Denatured Serum Albumin,” Int. Arch. Allergy 41:237–247 (1971).
Wissler, J. H. “A New Biologically Active Peptide System Related to Classical Anaphylatoxin.” Experientia 27:1447–1448 (1971).
Wissler, J. H. “Chemistry and Biology of the Anaphylatoxin Related Serum Peptide System. I. Purification, Crystallization and Properties of Classical Anaphylatoxin from Rat Serum,” Eur. J. Immunol. 2:73–83 (1972a).
Wissler, J. H. “Chemistry and Biology of The Anaphylatoxin Related Serum Peptide System. II. Purification, Crystallization, and Properties of Cocytotaxin, a Basic Peptide from Rat Serum,” Eur. J. Immunol. 2:84–89 (1972b).
Wissler, J. H., and Sorkin, E. “Structural Requirements of Proteins for Their Chemotactic Recognition by Neutrophil Phagocytes.” Commun. XXIVth Int. Congress of Pure and Applied Chemistry, Hamburg, 1973 (in press— 1973).
Wissler, J. H., Stecher, V. J., and Sorkin, E. “Biochemistry and Biology of a Leukotactic Binary Serum Peptide System Related to Anaphylatoxin,” Int. Arch. Allergy 42:722–747 (1972a).
Wissler, J. H., Stecher, V. J. and Sorkin, E. “Chemistry and Biology of the Anaphylatoxin Related Serum Peptide System. III. Evaluation of Leukotactic Activity As a Property of a New Peptide System with Classical Anaphylatoxin and Cocytotaxin As Components,” Eur. J. Immunol. 2:90–96 (1972b).
Wissler, J. H., Stecher, V. J., and Sorkin, E. “Regulation of Chemotaxis by the Anaphylatoxin Related Peptide System.” Proc. XXth Colloquium Protides of the Biological Fluids, H. H. Peeters, ed. Oxford: Pergamon Press, Abstr. Commun., p. 111 (in press—1972c).
Wissler, J. H., Stecher, V. J., Sorkin, E., and Jungi, Th. W. “Mechanism of Leucotaxis.” Abstr. Commun. 4th., Tagung Gesellschaft für Immunologie, Bern, 1972, p. 61 (1972d).
Wissler, J. H., Stecher, V. J., and Sorkin, E. “Secondary Structural Properties of Anaphylatoxin Preparations and Chemotactic Activity for Neutrophils.” Abstr. Commun. Vth, Int. Complement Workshop, La Jolla, 1973, J. Immunol. (in press—1973a).
Wissler, J. H., Stecher, V. J., and Sorkin, E. “Chemistry and Biology of the Anaphylatoxin Related Serum Peptide System. VI. On the Mechanism of Chemotaxis and of Cellular Recognition oof Neutrophil Leukocytes” (manuscript in preparation—1973b).
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Wissler, J.H., Stecher, V.J., Sorkin, E. (1974). Cyclic AMP and Chemotaxis of Leukocytes. In: Braun, W., Lichtenstein, L.M., Parker, C.W. (eds) Cyclic AMP, Cell Growth, and the Immune Response. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86026-3_22
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DOI: https://doi.org/10.1007/978-3-642-86026-3_22
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