Abstract
Two major questions concerning the role of cyclic adenosine 3′,5′-monophosphate (cyclic AMP) in lymphocyte metabolism and function have been focused upon in recent years:
-
(1)
What role does cyclic AMP play in mediating hormonal influences to modify lymphocyte proliferation and function?
-
(2)
Do mitogens initiate proliferation by using a second-messenger system like cyclic AMP?
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allwood, G., Asherson, G. L., Davey, M. Jean, and Goodford, P. J. “The Early Uptake of Radioactive Calcium by Human Lymphocytes Treated with Phytohemagglutinin.” Immunology, 21:500–516 (1971).
George, W. J., Poison, J. B., O’Toole, A. G., and Goldberg, N. D. “Elevation of Guanosine 3′,5′-Cyclic Phosphate in Rat Heart After Perfusion with Acetylcholine.” Proc. Nat. Acad. Sci., 66:398–403 (1970).
Goldberg, N., Haddox, M., Hartle, D., and Hadden, J. “The Biological Role of Cyclic 3′,5′ Guanosine Monophosphate. Proc. V International Congress Pharmacology.” Basel: Karger (in press) (1973a).
Goldberg, N. D., Haddox, M. R., and O’Dea, R. F. Advances in Cyclic Nucleotide Research: Cyclic GMP, vol. 3. New York: Raven Press (in press) (1973b).
Goldberg, N. D., Haddox, M. K., Lopez, C., Estensen, R., and Hadden, J. W. “Biological Dualism Between Cyclic GMP and Cyclic AMP in Cell Proliferation and Other Cellular Processes.” (In this volume.)
Hadden, J. W., Hadden, E. M., and Middleton, E., Jr. “Lymphocyte Blast Transformation. I. Demonstration of Adrenergic Receptors in Human Peripheral Lymphocytes.” Cellular Immunology 1:583–595 (1970).
Hadden, J. W., Hadden, E. M., Middleton, E., Jr., and Good, R. A. “Lymphocyte Blast Transformation. II. The Mechanism of Action of Alpha Adrenergic Receptor Effects.” International Archives of Allergy and Applied Immunology 40:526–539 (1971a).
Hadden, J. W., Hadden, E. M., and Good, R. A. “Adrenergic Mechanisms in Human Lymphocyte Metabolism.” Biochem. Biophys. Acta 237:339–347 (1971b).
Hadden, J. W., Hadden, E. M., Haddox, M. K., and Goldberg, N. D. “Guanosine 3′:5′-Cyclic Monophosphate: A Possible Intracellular Mediator of Mitogenic Influences in Lymphocytes.” Proc. Nat. Acad. Sci. 69:3024–3027 (1972).
Hadden, J. W., Hadden, E. M., Meetz, G., Good, R. A., Haddox, M. K., and Goldberg, N. D. “Guanosine Cyclic 3′5′ Monophosphate: A Cholinergic Mediator in Lymphocytes Modulating Cellular and Nuclear Metabolism.” Proc. Nat. Acad. Sci. (In preparation.)
Jost, J. P., and Sahib, M. K. “Role of Cyclic Adenosine 3′,5′-Monophosphate in the Induction of Hepatic Enzymes.” J. Biol. Chem. 246:1623–1629 (1971).
Langan, T. A. “Phosphorylation of Histones in Vivo Under the Control of Cyclic AMP and Hormones.” In Role of Cyclic AMP in Cell Function. New York: Raven Press (1970).
Leu, R. W., Eddleston, A. L. W. F., Hadden, J. W., and Good, R. A. “Mechanism of Action of Migration Inhibitory Factor (MIF).” J. Exp. Med. 136:589–603 (1972).
MacManus, J. P., and Whitfield, J. F. “Control of Normal Cell Proliferation (in Vivo and Vitro) by cAMP and Several Agents That Use This Cyclic Nucleotide as Their Mediator.” (In this volume.)
Pogo, B. G. T., Allfrey, V. G., and Mirsky, A. E. “RNA Synthesis and Histone Acetylation During the Course of Gene Activation in Lymphocytes.” Proc. Nat. Acad. Sci. 55:805–812 (1966).
Schultz, G., Hardman, J. G., Davis, J. W., Schultz, K., and Sutherland, E. W. “Cyclic GMP and Cyclic AMP in Ductus Deferens and Submaxillary Gland of the Rat.” Fifth International Congress of Pharmacology: Abstracts of Volunteer Papers, p. 206 (1972).
Smith, J. W., Steiner, A. L., Newberry, W. M., Jr., and Parker, C. W. “Cyclic Adenosine 3′, 5′-Monophosphate in Human Lymphocytes. Alterations After Phytohemagglutinin Stimulation.” J. Clin. Invest. 50:432–448 (1971).
Strom, T. B., Deisseroth, A., Morganroth, J., Carpenter, C. B., and Merrill, J. P. “Alteration of the Cytotoxic Action of Sensitized Lymphocytes by Cholinergic Agents and Activators of Adenylate Cyclase.” Proc. Nat. Acad. Sci. 69:2995–2999 (1972).
Whitfield, J. F., and MacManus, J. P. “Calcium-Mediated Effects of Cyclic GMP on the Stimulation of Thymocyte Proliferation by Prostaglandin E.” Proc. Soc. Exp. Biol. and Med. 139:818–824 (1972).
Willingham, M. C., Johnson, G. S., and Pastan, I. “Control of DNA Synthesis and Mitosis in 3T3 Cells by Cyclic AMP.” Biochem. Biophys. Res. Comm. 48:743–748 (1972).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1974 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Hadden, J.W., Hadden, E., Goldberg, N.D. (1974). Cyclic GMP and Cyclic AMP in Lymphocyte Metabolism and Proliferation. In: Braun, W., Lichtenstein, L.M., Parker, C.W. (eds) Cyclic AMP, Cell Growth, and the Immune Response. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86026-3_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-86026-3_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-86028-7
Online ISBN: 978-3-642-86026-3
eBook Packages: Springer Book Archive