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Cyclic GMP: Vestige or Another Intracellular Messenger?

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Cyclic AMP, Cell Growth, and the Immune Response

Abstract

For some time, the possibility has been entertained that cyclic AMP might not be unique as an intracellular mediator of effects of hormones and other alterations in the extracellular environment. The discovery of cyclic GMP in rat urine by Ashman et al. (1963) has stimulated a substantial amount of investigation of this nucleotide as a potential regulatory agent. Progress in elucidating the role(s) of cyclic GMP has been slow. This has been due in part to the difficulty of methodology available for studying the endogenous nucleotide and in part to the inherently tedious task of finding an unknown function of a substance that is present in very small amounts.

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Authors
  1. Joel G. Hardman
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  2. Günter Schultz
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  3. Earl W. Sutherland
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Editors and Affiliations

  1. Department of Medicine, The Johns Hopkins University School of Medicine at The Good Samaritan Hospital, Baltimore, Maryland, 21239, USA

    Lawrence M. Lichtenstein

  2. Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Charles W. Parker

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© 1974 Springer-Verlag Berlin Heidelberg

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Hardman, J.G., Schultz, G., Sutherland, E.W. (1974). Cyclic GMP: Vestige or Another Intracellular Messenger?. In: Braun, W., Lichtenstein, L.M., Parker, C.W. (eds) Cyclic AMP, Cell Growth, and the Immune Response. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86026-3_18

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  • DOI: https://doi.org/10.1007/978-3-642-86026-3_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-86028-7

  • Online ISBN: 978-3-642-86026-3

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