Abstract
Following transplantation with a histoincompatible graft, a small proportion of host thymus-derived (T) lymphocytes contact donor cell structures bearing histocompatibility antigens (Stober and Gowans, 1965). This process is made possible by specific recognition units on lymphocytic surfaces (David et al., 1964). Clonal proliferation of those lymphocytes that bear receptors for donor histocompatibility antigens ensues (Gowans and McGregor, 1965; Turk, 1967). A subpopulation of antigen-sensitized T lymphocytes, which have undergone proliferation, are believed to constitute the effector lymphocyte population, which is cytopathic to donor cells (lymphocyte-mediated cytotoxicity) (Rosenau and Moon, 1961; Cerottini et al., 1970a, b). Effector T lymphocytes elaborate diffusible, biologically active agents collectively termed lymphokines (Lawrence and Landy, 1969). It has not been ascertained whether the cytotoxic lymphocytes are the same effector cells as those responsible for lymphokine secretion. The nature of the cytotoxic process is enigmatic; however, it may be mediated in part via synthesis and secretion of cytotoxic lymphokines (i. e., lymphotoxin) (Ruddle and Waksman, 1967).
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Strom, T.B., Deisseroth, A., Morganroth, J., Carpenter, C.B., Merrill, J.P. (1974). Modulation of Cytotoxic T Lymphocyte Function by Cyclic 3′,5′-Mononucleotides. In: Braun, W., Lichtenstein, L.M., Parker, C.W. (eds) Cyclic AMP, Cell Growth, and the Immune Response. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86026-3_17
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DOI: https://doi.org/10.1007/978-3-642-86026-3_17
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