Cardiomyopathy Diagnostic Criteria and Classification

  • George E. Burch
  • Thomas Giles


The history of cardiomyopathy from 1800 to 1965 was briefly reviewed by Mattingly (49). It is evident from this review that serious interest in diseases of the myocardium developed only during the present century. In recent years considerable knowledge has been gained concerning the ultrastructure and function of the normal and diseased myocardium. However, it seems that progress in clinical application of accumulating knowledge has possibly been retarded because of differences of opi nion and confusion regarding criteria for diagnosis and classification of the cardiomyopathies.


Ischemic Cardiomyopathy Myocardial Disease Viral Myocarditis Coxsackie Virus Ventricular Outflow Tract Obstruction 
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  1. 1.
    Alexander, C. S. Idiopathic heart disease. I. Analysis of 100 cases, with special reference to chronic alcoholism. Am. J. Med., 41:213, 1966.PubMedCrossRefGoogle Scholar
  2. 2.
    Alexander, C. S. Electron microscopic observations in alcoholic heart disease. Br. Heart J., 29:200, 1967.PubMedCrossRefGoogle Scholar
  3. 3.
    Bashour, F. and Winchell, P. “Postpartal” heart disease-A syndrome? Ann. Intern. Med., 40:803, 1954.Google Scholar
  4. 4.
    Becker, F. F. and Taube, H. Myocarditis of obscure etiology associated with pregnancy. N. Engl. J. Med., 266:62, 1962.PubMedCrossRefGoogle Scholar
  5. 5.
    Benchimol, A. B., Carneiro, R. D., and Schlesinger, P. Post-partum heart disease. Br. Heart J., 21:89, 1959.PubMedCrossRefGoogle Scholar
  6. 6.
    Brigden, W. Uncommon myocardial diseases; the non-coronary cardiomyopathies. Lancet, 2:1179, 1243, 1957.CrossRefGoogle Scholar
  7. 7.
    Alcoholic cardiomyopathy. In Brest, A., ed., Burcn, G., guest ed. Cardiovascular Clinics: Cardiomyopathy. Philadelphia, F. A. Davis Co., 1972, Vol. 4, No. 1, pp. 187–201.Google Scholar
  8. 8.
    Brockington, I. F. Postpartum hypertensive heart failure. Am. J. Cardiol., 27:650, 1971.PubMedCrossRefGoogle Scholar
  9. 9.
    Burch, G. E. Interesting aspects of geriatric cardiology. Am. Heart J., 89:99, 1975.PubMedCrossRefGoogle Scholar
  10. 10.
    Burch, G. E., Colcolough, H. L., Harb, J. M., and Tsui, C. Y. The effect of ingestion of ethyl alcohol, wine and beer on the myocardium of mice. Am. J. Cardiol., 27:522, 1971.PubMedCrossRefGoogle Scholar
  11. 11.
    and DePasquale, N. P. Viral myocarditis. In Wolstenholme, G. E. W. and O’Connor, M., ed. Ciba Foundation Symposium on Cardiomyopathies. London, J. and A. Churchill, Ltd., 1964, pp. 376–407.Google Scholar
  12. 12.
    and DePasquale, N. P. Recognition and prevention of cardiomyopathy. Circulation, 42 :A– 47, 1970.Google Scholar
  13. 13.
    and Giles, T. D. Alcoholic cardiomyopathy: Concept of the disease and its treatment. Am. J. Med., 50:141, 1971.PubMedCrossRefGoogle Scholar
  14. 14.
    and Giles, T. D. Senile cardiomyopathy. J. Chron. Dis., 24:1, 1971.PubMedCrossRefGoogle Scholar
  15. 15.
    and Giles, T. D. The role of viruses in the production of heart disease. Am. J. Cardiol., 29:231, 1972.PubMedCrossRefGoogle Scholar
  16. 16.
    and Giles, T. D. Diagnosis and treatment of cardiomyopathy. In Changing Concepts in Car diovascular Disease. Proceedings of the American College of Cardiology. Baltimore, The Williams and Wilkins Co., 1972, pp. 80–95.Google Scholar
  17. 17.
    and Giles, T. D. Ischemic cardiomyopathy: Diagnostic, pathophysiologic and therapeutic considerations. In Brest, A., ed., Burch, G., guest ed. Cardiovascular Clinics: Cardiomyopathy. Philadelphia, F. A. Davis Co., 1972, Vol. 4, No. 1, pp. 203–220.Google Scholar
  18. 18.
    and Giles, T. D. Incidence of cardiomyopathy. In Bajusz, E., and Rona, G., ed., with Brink, A. J. and Lochner, A. Recent Advances in Cardiac Structure and Metabolism: Cardiomyopathies. Baltimore, University Park Press, 1973, Vol. 2, pp. 59–76.Google Scholar
  19. 19.
    and Giles, T. D. Alcoholic cardiomyopathy. In Kissin, B., and Begleiter, H., ed. The Biology of Alcoholism: Clinical Pathology. New York, Plenum Press, 1974, Vol. 3, pp. 435–460.Google Scholar
  20. 20.
    Giles, T. D., and Colcolough, H. L. Ischemic cardiomyopathy. Am. Heart J., 79:291, 1970.PubMedCrossRefGoogle Scholar
  21. 21.
    Giles, T. D., and Tsui, C. Y. Postpartal cardiomyopathy. In Brest, A., ed., Burch, G., guest ed. Cardiovascular Clinics: Cardiomyopathy. Philadelphia, F. A. Davis Co., 1972, Vol. 4, No. 1, pp. 269–282.Google Scholar
  22. 22.
    Harb, J. M., Colcolough, H. L., and Tsui, C. Y. The effect of prolonged consumption of beer, wine and ethanol on the myocardium of the mouse. The Johns Hopkins Med. J., 129:130, 1971.Google Scholar
  23. 23.
    Sohal, R., and Fairbanks, L. D. Ultrastructural changes in Drosophila heart with age. Arch. Pathol., 89:128, 1970.PubMedGoogle Scholar
  24. 24.
    Sun, S. C., Chu, K. C., Sohal, R. S., and Colcolough, H. L. Interstitial and Coxsackie virus B myocarditis in infants and children. J.A.M.A., 203:1, 1968.PubMedCrossRefGoogle Scholar
  25. 25.
    Sun, S. C., Colcolough, H. L., Sohal, R. S., and DePasquale, N. P. Coxsackie virus valvulitis and myocarditis observed at routine autopsy. Experientia, 23:1041, 1967.PubMedCrossRefGoogle Scholar
  26. 26.
    and Walsh, J. J. Cardiac insufficiency in chronic alcoholism. Am. J. Cardiol., 6:864, 1960.PubMedCrossRefGoogle Scholar
  27. 27.
    Davies, J. N. P. African endomyocardial fibrosis. In Brest, A., ed, Burch, G., guest ed. Cardiovascular Clinics: Cardiomyopathy. Philadelphia, F. A. Davis Co., 1972, Vol. 4, No. 1, pp. 345–359.Google Scholar
  28. 28.
    Dock, W. Cardiomyopathies of the senescent and senile. In Brest, A., ed., Burch, G., guest ed. Cardiovascular Clinics: Cardiomyopathy. Philadelphia, F. A. Davis Co., 1972, Vol. 4, No. 1, pp. 361–373.Google Scholar
  29. 29.
    Eliaser, M. Jr. and Giansiracusa, F. J. The heart and alcohol. Calif. Med., 84:234, 1956.PubMedGoogle Scholar
  30. 30.
    Epstein, S. E., Henry, W. L., Clark, C. E., Roberts, W. C., Maron, B. J., Ferrans, V. J., Redwood, D. R., and Morrow, A. G. NIH Conference: Asymmetric septal hypertrophy. Ann. Intern. Med., 81:650, 1974.Google Scholar
  31. 31.
    Evans, W. Alcoholic cardiomyopathy. Am. Heart J., 61:556, 1961.PubMedCrossRefGoogle Scholar
  32. 32.
    Faber, P. A. and Glasgow, L. A. Viral myocarditis during pregnancy: Encephalomyocarditis virus infection in mice. Am. Heart J., 80:96, 1970.CrossRefGoogle Scholar
  33. 33.
    Fejfar, Z. Definition and classification of the cardiomyopathies. Pathol. Microbiol, 35:17, 1970.Google Scholar
  34. 34.
    Giles, T. D., Burch, G. E., and Martinez, E. C. An echocardiographic study of cardiomyopathy. To be published.Google Scholar
  35. 35.
    Goodwin, J. F., Gordon, H., Hollman, A., and Bishop, M. B. Clinical aspects of cardiomyopathy. Brit. Med. J., 1:69, 1961.PubMedCrossRefGoogle Scholar
  36. 36.
    and Oakley, C. M. The cardiomyopathies. Br. Heart J., 34:545, 1972.PubMedCrossRefGoogle Scholar
  37. 37.
    Gould, L., Reddy, C. V. R., Patel, N., and Gomprecht, R. F. Effects of a cocktail on the human conduction system. Clin. Res., 22:277A, 1974 (abstr.).Google Scholar
  38. 38.
    Gould, S. E. and Ioannides, G. Ischemic heart disease. In Gould, S. E., ed. Pathology of the Heart and. Blood Vessels. Springfield, I11., Charles C. Thomas, 1968, pp. 601–648.Google Scholar
  39. 39.
    Grist, N. R. and Bell, E. J. Coxsackie viruses and the heart (Editorial). Am. Heart J., 77:295, 1969.PubMedCrossRefGoogle Scholar
  40. 40.
    Helin, M., Savola, J., and Lapinleimu, K. Cardiac manifestations during a Coxsackie B5 epidemic. Br. Med. J., 3:97, 1968.PubMedCrossRefGoogle Scholar
  41. 41.
    Hibbs, R. G., Ferrans, V. J., Black, W. C., Walsh, J. J., and Burch, G. E. Virus-like particles in the heart of a patient with cardiomyopathy: An electron microscopic and histochemical study. Am. Heart J., 69:327, 1965.PubMedCrossRefGoogle Scholar
  42. 42.
    Hibbs, R. G., Ferrans, V. J., Black, W. C., Weilbaecher, D. G., Walsh, J. J., and Burch, G. E. Alcoholic cardiomyopathy: An electron microscopic study. Am. Heart J., 69:766, 1965.PubMedCrossRefGoogle Scholar
  43. 43.
    Hudson, R. E. B. The cardiomyopathies: Order from chaos. Am. J. Cardiol., 25:70, 1970.PubMedCrossRefGoogle Scholar
  44. 44.
    Lewes, D., Rainford, D. J., and Lane, W. F. Symptomless myocarditis and myalgia in viral and Mycoplasma pneumoniae infections. Br. Heart J., 36:924, 1974.PubMedCrossRefGoogle Scholar
  45. 45.
    Lieber, C. S., Spritz, N., and DeCarli, L. M. Accumulation of triglycerides in heart and kidney after alcohol ingestion. J. Clin. Invest., 45:1041, 1966 (abstr.).Google Scholar
  46. 46.
    Lyon, E. Virus Diseases and the Cardiovascular System. New York, Grune and Stratton, 1956.Google Scholar
  47. 47.
    Maines, J. E. Ill and Aldinger, E. E. Myocardial depression accompanying chronic consumption of alcohol. Am. Heart J., 73:55, 1967.PubMedCrossRefGoogle Scholar
  48. 48.
    Massumi, R. A., Rios, J. C., Gooch, A. S., Nutter, D., DeVita, V. T., and Datlow, D. W. Primary myocardial disease: Report of fifty cases and review of the subject. Circulation, 31:19, 1965.PubMedCrossRefGoogle Scholar
  49. 49.
    Mattingly, T. W. Changing concepts of myocardial diseases. J.A.M.A., 191:33, 1965.PubMedCrossRefGoogle Scholar
  50. 50.
    Mattingly, T. W. The clinical concept of primary myocardial disease: A classification and a few notes on management and prognosis. Circulation, 32:845, 1965.PubMedCrossRefGoogle Scholar
  51. 51.
    Mitchell, J. H. and Cohen, L. S. Alcohol and the heart. Mod. Concepts Cardiovasc. Dis., 39:109, 1970.PubMedGoogle Scholar
  52. 52.
    Morgan, R. R. Heart disease and alcoholism. Circulation, 24:1001, 1961.Google Scholar
  53. 53.
    Morin, Y. and Daniel, P. Quebec beer drinkers’ cardiomyopathy: Etiological considerations. Can. Med. Assoc. J., 97:926, 1967.PubMedGoogle Scholar
  54. 54.
    Musser, J. H., Sodeman, W. A., and Turner, R. H. Heart failure or acute nephritis with onset about 3 weeks after delivery. Ann. Intern. Med., 12:739, 1938.Google Scholar
  55. 55.
    Opie, L. H. Metabolism of the heart in health and disease. Part III. Am. Heart J., 77:383, 1969.Google Scholar
  56. 56.
    Pankey, G. A. Effect of viruses on the cardiovascular system. Am. J. Med. Sci., 250:103, 1965.PubMedCrossRefGoogle Scholar
  57. 57.
    Raftery, E. B., Banks, D. C., and Oram, S. Occlusive disease of the coronary arteries presenting as primary congestive cardiomyopathy. Lancet, 2:1146, 1969.PubMedGoogle Scholar
  58. 58.
    Regan, T. J., Koroxenidis, G., Moschos, C. B., Oldewurtel, H. A., Lehan, P. H., and Hellems, H. K. The acute metabolic and hemodynamic responses of the left ventricle to ethanol. J. Clin. Invest., 45:270, 1966.PubMedCrossRefGoogle Scholar
  59. 59.
    Regan, T. J., Levinson, G. E., Oldewurtel, H. A., Frank, M. J., Weisse, A. B., and Moschos, C. B. Ventricular function in noncardiacs with alcoholic fatty liver: Role of ethanol in the production of cardiomyopathy. J. Clin. Invest., 48:397, 1969.PubMedCrossRefGoogle Scholar
  60. 60.
    Roberts, W. C. and Ferrans, V. J. Morphologic observations in the cardiomyopathies. In Fowler, N. O., ed. Myocardial Diseases. New York, Grune and Stratton, 1973, pp. 59–115.Google Scholar
  61. 61.
    Rose, G. A. and Wilson, R. R. Unexplained heart failure in the aged. Br. Heart J., 21:511, 1959.PubMedCrossRefGoogle Scholar
  62. 62.
    Rosen, S. M. Puerperal cardiomyopathy. Br. Med. J., 2:5, 1959.PubMedCrossRefGoogle Scholar
  63. 63.
    Rubin, E. and Lieber, C. S. Fatty liver, alcoholic hepatitis and cirrhosis produced by alcohol in primates. N. Engl. J. Med., 290:128, 1974.PubMedCrossRefGoogle Scholar
  64. 64.
    Sainani, G. S., KrompotiC., E., and Slodki, S. J. Adult heart disease due to the Coxsackie virus B in fection. Medicine, 47:133, 1968.PubMedCrossRefGoogle Scholar
  65. 65.
    Sanders, V. Idiopathic diseases of myocardium: A prospective study. Arch. Intern. Med., 112:661, 1963.PubMedGoogle Scholar
  66. 66.
    Saphir, O. Myocarditis: A general review with analysis of 240 cases. Arch. Pathol., 32:1000, 1941.Google Scholar
  67. 67.
    Myocarditis: A general review with analysis of 240 cases. Arch. Pathol., 33:88, 1942.Google Scholar
  68. 68.
    Schenk, E. A. and Cohen, J. The heart in chronic alcoholism: Clinical and pathological findings. Pathol. Microbiol., 35:96, 1970.Google Scholar
  69. 69.
    Smith, W. G. Coxsackie B myopericarditis in adults. Am. Heart J., 80:34, 1970.PubMedCrossRefGoogle Scholar
  70. 70.
    Spann, J. F. Jr., Mason, D. T., Beiser, G. D., and Gold, H. K. Actions of ethanol on the contractile state of the normal and failing cat papillary muscle. Clin. Res., 16:249, 1968 (abstr.).Google Scholar
  71. 71.
    Sulkin, N. M. Senescence as reflection of cellular changes. Triangle, 8:304, 1968.PubMedGoogle Scholar
  72. 72.
    Walsh, J. J. and Burch, G. E. Postpartal heart disease. Arch. Intern. Med., 108:817, 1961.PubMedCrossRefGoogle Scholar
  73. 73.
    Wendt, V. E., Wu, C., Balcon, R., Doty, G., and Bing, R. J. Hemodynamic and metabolic effects of chronic alcoholism in man. Am. J. Cardiol., 15:175, 1965.PubMedCrossRefGoogle Scholar
  74. 74.
    Ajluni, R., and Bruce, T. A. Acute effects of alcohol on the human myocardium. Am. J. Car diol., 17:804, 1966.Google Scholar
  75. 75.
    Yatteau, R. F., Peter, R. H., Behar, V. S., Bartel, A. G., Rosati, R. A., and Kong, Y. Ischemic cardiomyopathy: The myopathy of coronary artery disease. Natural history and results of medical versus surgical treatment. Am. J. Cardiol., 34:520, 1974.PubMedCrossRefGoogle Scholar

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© Springer-Verlag New York Inc. 1976

Authors and Affiliations

  • George E. Burch
  • Thomas Giles

There are no affiliations available

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