Induced Chromosomal Aberrations with Special Reference to Man

  • Kurt Hirschhorn
  • Maimon H. Cohen

Abstract

Induced mutagenesis has long been an active and fruitful area of genetic research. The recent technical advances in tissue culture techniques, as well as in chromosome preparations, have greatly facilitated the expansion of this field to the chromosomal level. Four general classes of exogenous agents have been described which are capable of causing chromosome aberrations and, therefore, possibly gene mutations as well: irradiation, viruses, physical stimuli, and chemicals. This last group can be further subdivided into those compounds affecting biosynthesis of macromolecules (DNA, RNA, and protein): antitumor agents, antibiotics, alkylating agents, nitroso-compounds, and a heterogeneous miscellaneous group (Lea, 1955; Revell, 1953; Kihlman, 1961, 1966; Oster-tag, 1966; Cohen and Shaw, 1965).

Keywords

Leukemia Recombination Ozone Caffeine Macromolecule 

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Copyright information

© Springer-Verlag New York Inc. 1969

Authors and Affiliations

  • Kurt Hirschhorn
    • 1
  • Maimon H. Cohen
    • 2
  1. 1.Division of Medical Genetics, Department of PediatricsMt. Sinai School of MedicineNew YorkUSA
  2. 2.Division of Human Genetics, Department of PediatricsState University of New York at Buffalo Medical School and Buffalo Children’s HospitalBuffaloUSA

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