Skip to main content
SpringerLink
Log in
Book cover

Colorectal Cancer pp 139–159Cite as

Dietary Fiber, Fiber-Containing Foods, and Colon Cancer Risk

  • Chapter

  • 132 Accesses

Abstract

A number of national agencies, many of which are involved in formulating public health policy, have recommended major increases in the consumption of dietary fiber. Among the justifications used for such recommendations is that this will help inhibit the development of colorectal cancer. Some agencies have even attempted to “identify” the type and level of fiber that is anticarcinogenic. However, such health claims are, in the opinion of this author, premature since the human data on dietary fiber and cancer is at best circumstantial and certainly not consistent. There are many studies in both humans and experimental animals that show no protective effect with fiber, while several reports even indicate an enhancing effect. It is therefore important to evaluate critically the scientific evidence both for and against the dietary fiber hypothesis. For some investigators working in this area of cancer control, the fiber question has almost become a religious issue with believers and skeptics. Unfortunately, this has led to a politicization of the issues and a certain lack of objectivity in interpretation of the data. This situation has been further complicated by commercial pressures to eat more fiber, the supplementation of prepared foods with fibers, and by aggressive advertising of fiber supplements to the medical profession and general public.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abraham R, Barbolt TA, Rodgers JB (1980) Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. Exp Mol Pathol 33: 133–143

    Article  PubMed  CAS  Google Scholar 

  • Adlercreutz H (1984) Does fiber-rich food containing animal lignan precursors protect against both colon and breast cancer? An extension of the “fiber hypothesis. ” Gastroenterology 86: 761–766

    PubMed  CAS  Google Scholar 

  • Arakawa S, Okumura M, Yamada S, Ito M, Tejima S (1986) Enhancing effect of carageenan on the induction of rat colonic tumors by 1,2-dimethylhydrazine and its relation to ß-glucuronidase activities in feces and other tissues. J Nutr Sci Vitaminol (Tokyo) 32: 481–485

    Article  CAS  Google Scholar 

  • Armstrong B, Doll R (1975) Environmental factors and cancer incidence and mortality indifferent countries, with special reference to dietary practices. Int J Cancer 15: 617–631

    Article  PubMed  CAS  Google Scholar 

  • Barbolt TA, Abraham R (1978) The effect of bran on dimethyl-hydrazine-induced colon carci-nogenesis in the rat. Proc Soc Exp Biol 157: 656–659

    PubMed  CAS  Google Scholar 

  • Barbolt TA, Abraham R (1980) Dose-response, sex difference, and the effect of bran in dimethylhydrazine-induced intestinal tumorigenesis in rats. Toxicol Appl Pharmacol 55:417 —422

    Google Scholar 

  • Barnes DS, Clapp NK, Scott SA, Oberst DL, Berry SG (1983) Effects of wheat, rice, corn and soybean bran on 1,2-dimethylhydrazine-induced large bowel tumorigenesis in F344 rats. Nutr Cancer 5: 1–9

    Article  PubMed  CAS  Google Scholar 

  • Bauer HG, Asp N-G, Oste R, Dahlqvist A, Fredlund PE (1979) Effect of dietary fiber on the induction of colorectal tumors and fecal ß-glucuronidase activity in the rat. Cancer Res 39: 3752–3756

    PubMed  CAS  Google Scholar 

  • Bauer HG, Asp N-G, Dahlqvist A, Fredlund PE, Nyman M, Oste R (1981) Effect of two kinds of pectin and guar gum on 1,2-dimethylhydrazine initiation of colon tumors and on fecal ß-glucuronidase activity in the rat. Cancer Res 41: 2518–2523

    PubMed  CAS  Google Scholar 

  • Bingham SA, Williams DRR, Cole TJ, James WPT (1979) Dietary fiber and regional large-bowel cancer mortality in Britain. Br J Cancer 40: 456–463

    Article  PubMed  CAS  Google Scholar 

  • Bingham SA, Williams DRR, Cummings JH (1985) Dietary fibre consumption in Britain: newestimates and their relation to large bowel cancer mortality. Br J Cancer 52: 399–402

    Article  PubMed  CAS  Google Scholar 

  • Bjelke E (1974 a) Case-control study in Norway. Scand J Gastroenterol 9 (Suppl 31):42–48

    Google Scholar 

  • Bjelke E (1974b) Case-control study in Minnesota. Scand J Gastroenterol 9 (Suppl 31): 49–53

    Google Scholar 

  • Bristol JB, Emmett PM, Heaton KW, Williamson RCN (1985) Sugar, fat, and the risk of colorectal cancer. Br Med J 291: 1467–1470

    Article  CAS  Google Scholar 

  • Bruce WR (1987) Recent hypotheses for the origin of colon cancer. Cancer Res 47: 4237–4242

    PubMed  CAS  Google Scholar 

  • Burkitt DP (1971) Epidemiology of cancer of the colon and rectum. Cancer 28: 3–13

    Article  PubMed  CAS  Google Scholar 

  • Byers T, Graham S (1984) The epidemiology of diet and cancer. Adv Cancer Res 41: 1–69

    Article  PubMed  CAS  Google Scholar 

  • Chen W-F, Patchefsky AS, Goldsmith HS (1978) Colonic protection from dimethylhydrazine by a high fiber diet. Surg Gynecol Obstet 147: 503–506

    PubMed  CAS  Google Scholar 

  • Clapp NK, Henke MA, London JF, Shock TL (1984) Enhancement of 1,2-dimethylhydrazine-induced large bowel tumorigenesis in Balb/c mice by corn, soybean, and wheat brans. Nutr Cancer 6: 77–85

    Article  PubMed  CAS  Google Scholar 

  • Cleave TL (1956) The neglect of natural principles in current medical practice. J Roy Nav Med Sery 42: 55–82

    Google Scholar 

  • Cohen BI, Raicht RF, Deschner EE, Takahashi M, Sarwal AN, Fazzini E (1980) Effect of cholic acid feeding on N-methyl-N-nitrosourea-induced colon tumors and cell kinetics in rats. J Natl Cancer Inst 64: 573–578

    PubMed  CAS  Google Scholar 

  • Craven PA, Pfanstiel J, DeRubertis FR (1987) Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids. J Clin Invest 79: 532–541

    Article  PubMed  CAS  Google Scholar 

  • Cruse JP, Lewin MR, Clark CG (1978) Failure of bran to protect against experimental colon cancer in rats. Lancet ii: 1278–1280

    Google Scholar 

  • Cummings JH (1983) Fermentation in the human large intestine: evidence and implications for health. Lancet i: 1206–1209

    Google Scholar 

  • Cummings JH, Branch WJ, Bjerrum L, Paerregaard A, Helms P, Burton R (1982) Colon cancer and large bowel function in Denmark and Finland. Nutr Cancer 4: 61–66

    Article  PubMed  CAS  Google Scholar 

  • Dales LG, Friedman GD, Ury HK, Grossman S, Williams SR (1979) A case-control study of relationships of diet and other traits to colorectal cancer in American Blacks. Am J Epidemiol 109:132 —144

    Google Scholar 

  • Doll R, Peto R (1981) The causes of cancer. Quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66: 1191–1308

    Google Scholar 

  • Drasar BS, Irving D (1973) Environmental factors and cancer of the colon and breast. Br J Cancer 27: 167–172

    Article  PubMed  CAS  Google Scholar 

  • Englyst HN, Bingham SA, Wiggins HS, Southgate DAT, Seppanen R, Helms P, Anderson V, Day KC, Choolun R, Collinson E, Cummings JH (1982) Nonstarch polysaccharide consumption in four Scandinavian populations. Nutr Cancer 4: 50–60

    Article  PubMed  CAS  Google Scholar 

  • Enstrom JE (1980) Health and dietary practices and cancer mortality among California Mor-mons. In: Chairns J, Lyon JL, Skolnick M (eds) Cancer incidence in defined populations. Banbury report no 4. Cold Spring Harbor, New York, pp 69–92

    Google Scholar 

  • Farber E (1984) The multistep nature of cancer development. Cancer Res 44: 4217–4223

    PubMed  CAS  Google Scholar 

  • Fleiszer D, Murray D, MacFarlane J, Brown RA (1978) Protective effect of dietary fiber against chemically induced bowel tumors in rats. Lancet ii: 552–553

    Google Scholar 

  • Freeman HJ, Spiller GA, Kim YS (1978) A double-blind study on the effect of purified cellulose dietary fiber on 1,2-dimethylhydrazine-induced rat colonic neoplasia. Cancer Res 38:2912 — 2917

    Google Scholar 

  • Freeman HJ, Spiller GA, Kim YS (1980) A double-blind study on the effects of different purified cellulose and pectin fiber diets on 1,2-dimethylhydrazine-induced rat colonic neoplasia. Cancer Res 40: 2661–2665

    PubMed  CAS  Google Scholar 

  • Freeman HJ, Spiller GA, Kim YS (1984) Effect of high hemicellulose corn bran in 1,2-dimethylhydrazine-induced rat intestinal neoplasia. Carcinogenesis 5: 261–264

    Article  PubMed  CAS  Google Scholar 

  • Galloway DJ, Owen RW, Jarrett F, Boyle P, Hill MJ, George WD (1986) Experimental colorectal cancer: the relationship of diet and faecal bile acid concentration to tumour induction. Br J Surg 73: 233–237

    Article  PubMed  CAS  Google Scholar 

  • Glauert HP, Bennick MR, Sander CH (1981) Enhancement of 1,2-dimethylhydrazine-induced colon carcinogenesis in mice by dietary agar. Food Cosmet Toxicol 19: 281–286

    Article  PubMed  CAS  Google Scholar 

  • Goldin BR, Gorbach SL (1976) The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer. J Natl Cancer Inst 57: 371–375

    PubMed  CAS  Google Scholar 

  • Graf E, Eaton JW (1985) Dietary suppression of colon cancer. Fiber or phytate. Cancer 56: 717–718

    Google Scholar 

  • Graham S, Dayal H, Swanson M, Mittelman A, Wilkinson G (1978) Diet in the epidemiology of cancer of the colon and rectum. J Natl Cancer Inst 61: 709–714

    PubMed  CAS  Google Scholar 

  • Gulliver WP, Kutty KP, Laher JM, Barrowman JA (1983) In vitro interaction of 7,12-dimethylbenz[a]anthracene and its biliary metabolites with dietary fibers. J Natl Cancer Inst 71: 207–210

    PubMed  CAS  Google Scholar 

  • Haenszel W, Berg JW, Segi M, Kurihara M, Locke FB (1973) Large-bowel cancer in Haiwaiian Japanese. J Natl Cancer Inst 51: 1765–1779

    PubMed  CAS  Google Scholar 

  • Haenszel W, Locke FB, Segi M (1980) A case-control study of large bowel cancer in Japan. J Natl Cancer Inst 64: 17–22

    PubMed  CAS  Google Scholar 

  • Helms P, Jorgensen IM, Paerregaard A, Bjerrum L, Poulsen L, Mosbech J (1982) Dietary patterns in Them and Copenhagen, Denmark. Nutr Cancer 4: 34–40

    Google Scholar 

  • Higginson J (1966) Etiological factors in gastrointestinal cancer in man. J Natl Cancer Inst 37: 527–545

    PubMed  CAS  Google Scholar 

  • Hill M, MacLennan R, Newcombe K (1979) Diet and large bowel cancer in three socioeconomic groups in Hong Kong. Lancet i: 436

    Google Scholar 

  • Hirayama T (1981) A large-scale cohort study on the relationship between diet and selected cancers of digestive organs. In: Bruce WR, Correa P, Lipkin M, Tannenbaum SR, Wilkins TD (eds) Gastrointestinal cancer: endogenous factors. Banbury report no 7. Cold Spring Harbor, New York, pp 409–429

    Google Scholar 

  • Hoff G, Moen IE, Trygg K, Frolich W, Sauar J, Vatn M, Gjone E, Larsen S (1986) Epidemiology of polyps in the rectum and sigmoid colon. Evaluation of nutritional factors. Scand J Gastroenterol 21: 199–204

    Google Scholar 

  • Howell MA (1985) Diet as an etiological factor in the development of cancers of the colon and rectum. J Chronic Dis 28: 67–80

    Article  Google Scholar 

  • Ingram DM, Castleden WM (1980) The effect of dietary lactulose on experimental large bowel cancer. Carcinogenesis 1: 893–895

    Article  PubMed  CAS  Google Scholar 

  • International Agency for Research on Cancer Intestinal Microecology Group (1977) Dietary fiber, transit-time, faecal bacteria, steroids and colon cancer in two Scandinavian populations. Lancet ii: 207–211

    Google Scholar 

  • Irving D, Drassar BS (1973) Fibre and cancer of the colon. Br J Cancer 28: 462–463

    Article  PubMed  CAS  Google Scholar 

  • Jacobs LR (1983) Enhancement of rat colon carcinogenesis by wheat bran consumption during the stage of 1,2-dimethylhydrazine administration. Cancer Res 43: 4057–4061

    PubMed  CAS  Google Scholar 

  • Jacobs LR (1984) Stimulation of rat colonic crypt cell proliferative activity by wheat branconsumption during the stage of 1,2-dimethylhydrazine administration. Cancer Res44: 2458 —2463

    Google Scholar 

  • Jacobs LR (1986 a) Enhancement of experimental colon cancer and production of colitis in rats fed sorbitol. Clin Res 35:441 A

    Google Scholar 

  • Jacobs LR (1986 b) Enhancement of experimental rat colon cancer with dietary lactulose. Gastroenterology 90:1473

    Google Scholar 

  • Jacobs LR, Lupton JR (1984) Effect of dietary fibers on rat large bowel mucosal growth and cell proliferation. Am J Physiol 246: G378 — G385

    PubMed  CAS  Google Scholar 

  • Jacobs LR, Lupton JR (1986) Relationship between colonic luminal pH, cell proliferation, and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets. Cancer Res 46:1727 —1734

    Google Scholar 

  • Jacobs LR, White FA (1983) Modulation of mucosal cell proliferation in the intestine of rats fed a wheat bran diet. Am J Clin Nutr 37: 945–953

    PubMed  CAS  Google Scholar 

  • Jain M, Cook GM, Davis FG, Grace MG, Howe GR, Miller AB (1980) A case-control study of diet and colo-rectal cancer. Int J Cancer 26: 757–768

    Article  PubMed  CAS  Google Scholar 

  • Kim YS, Tsao D, Marita A, Bella A (1982) Effect of sodium butyrate on three human colorectal adenocarcinoma cell lines in culture. In: Malt RA, Williamson RCN (eds) Colonic carcinogenesis. MTP Press, Lancaster, pp 317–323

    Google Scholar 

  • Knox EG (1977) Foods and diseases. Br J Prey Soc Med 31: 71–80

    CAS  Google Scholar 

  • Kritchevsky D, Story JA (1974) Binding of bile salts in vitro by non-nutritive fiber. J Nutr 104: 458–462

    PubMed  CAS  Google Scholar 

  • Kroes R, Beems RB, Bosland MC, Bunnik GSJ, Sinkeldam EJ (1986) Nutritional factors in lung, colon, and prostate carcinogenesis in animal models. Fed Proc Fed Am Soc Exp Biol 45: 136–141

    CAS  Google Scholar 

  • Kromhout D, Bosschieter EB, de Lezenne Coulander C (1982) Dietary fiber and 10-year mortality from coronary heart disease, cancer and all causes. The Zutphen study. Lancet ii: 518–522

    Google Scholar 

  • Kruh J (1982) Effect of sodium butyrate, a new pharmacological agent, on cells in culture. Mol Cell Biochem 42: 65–82

    PubMed  CAS  Google Scholar 

  • Kune S, Kune GA, Watson LF (1987) Case-control study of dietary etiological factors: the Melbourne colorectal cancer study. Nutr Cancer 9: 21–42

    Article  PubMed  CAS  Google Scholar 

  • Kuratsune M, Honda T, Englyst HN, Cummings JH (1986) Dietary fiber in the Japanese diet as investigated in connection with colon cancer risk. Jpn J Cancer Res 77: 736–738

    PubMed  CAS  Google Scholar 

  • Lindop R, Tasman-Jones C, Thomsen LL, Lee SP (1985) Cellulose and pectin alter intestinal ß-glucuronidase (EC 3.2.1.31) in the rat. Br J Nutr 54: 21–26

    Article  PubMed  CAS  Google Scholar 

  • Liu K, Stamler J, Moss D, Garside D, Persky V, Soltero I (1979) Dietary cholesterol, fat and fibre, and colon-cancer mortality. Lancet ii: 782–785

    Google Scholar 

  • Lupton JR, Coder DM, Jacobs LR (1985) Influence of luminal pH on rat large bowel epithelial cell cycle. Am J Physiol 249: G382 — G388

    PubMed  CAS  Google Scholar 

  • Lyon JL, Sorenson AW (1978) Colon cancer in a low-risk population. Am J Clin Nutr 31: S227 — S230

    PubMed  CAS  Google Scholar 

  • Lyon JL, Gardner JW, West DW, Mahoney AM (1983) Methodological issues in epidemiological studies in diet and cancer. Cancer Res (Suppi) 43:2392 s-2396 s

    Google Scholar 

  • Lyon JL, Mahoney AW, West DW, Gardner JW, Smith KR, Sorensen AW, Stanish W (1987)

    Google Scholar 

  • Energy intake: its relationship to colon cancer risk. J Natl Cancer Inst 78:853–861

    Google Scholar 

  • Macquart-Moulin G, Riboli E, Cornée J, Charnay B, Berthezène P, Day N (1986) Case-control study on colorectal cancer and diet in Marseilles. Int J Cancer 38: 183–191

    Article  PubMed  CAS  Google Scholar 

  • Macquart-Moulin G, Riboli E, Cornée J, Kaaks R, Berthezène P (1987) Colorectal polyps and diet: a case-control study in Marseilles. Int J Cancer 40: 179–188

    Article  Google Scholar 

  • Mallett AK, Wise A, Rowland IR (1983) Effect of dietary cellulose on the metabolic activity of the rat cecal microflora. Arch Toxicol 52: 311–317

    Article  PubMed  CAS  Google Scholar 

  • Mallett AK, Wise A, Rowland IR (1984) Hydrocolloid food additives rat caecal microbial enzyme activities. Food Chem Toxicol 22: 415–418

    Article  PubMed  CAS  Google Scholar 

  • Mallett AK, Rowland IR, Bearne CA (1986) Influence of wheat bran on some reductive and hydrolytic activities of the rat cecal flora. Nutr Cancer 8: 125–131

    Article  PubMed  CAS  Google Scholar 

  • Manousos O, Day NE, Trichopoulos D, Gerovassilis F, Tzonou A,Polychronopoulou A (1983) Diet and colorectal cancer: a case-control study in Greece. Int J Cancer 32: 1–5

    CAS  Google Scholar 

  • Martinez I, Torres R, Frias Z, Colon JR, Fernandez N (1979) Factors associated with adenocarcinomas of the large bowel in Puerto Rico. In: Birch JM (ed) Epidemiology. Advances in medical oncology, research and education, vol 3. Pergamon, New York, pp 45–52

    Google Scholar 

  • McKeown-Eyssen GE, Bright-See E (1984) Dietary factors in colon cancer: international relationships. Nutr Cancer 6: 160–170

    Article  PubMed  CAS  Google Scholar 

  • Minowa M, Bingham S, Cummings JH (1983) Dietary fiber intake in Japan. Hum Nutr Appl Nutr 37A: 113–119

    PubMed  CAS  Google Scholar 

  • Mitchell BL, Lawson MJ, Davies M, Grant MK, Roediger WEW, Illman RJ, Topping DL (1985) Volatile fatty acids in the human intestine: studies in surgical patients. Nutr Res 5: 1089–1092

    Article  Google Scholar 

  • Mizutani I, Mitsuoka T (1983) Effect of Konjac mannan on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in Fischer F344 rats. Cancer Lett 19: 1–6

    Article  PubMed  CAS  Google Scholar 

  • Modan B, Barell V, Lubin F, Modan M, Greenberg RA, Graham S (1975) Low-fiber intake as an etiological factor in cancer of the colon. J Natl Cancer 55: 15–18

    CAS  Google Scholar 

  • Morgenstern H (1982) Uses of ecological analysis in epidemiological research. Am J Public Health 72: 1336–1344

    Article  PubMed  CAS  Google Scholar 

  • Nigro ND, Bull AW, Klopfer BA, Pak MS, Campbell RL (1979) Effect of dietary fiber onazoxymethane-induced intestinal carcinogenesis in rats. J Natl Cancer Inst 62: 1097–1102

    PubMed  CAS  Google Scholar 

  • Nyman M, Asp N-G (1982) Fermentation of dietary fiber components in the rat intestinal tract.Br J Nutr 47: 357–366

    CAS  Google Scholar 

  • Pence BC, Buddingh F, Yang SP (1986) Multiple dietary factors in the enhancement of dimethyl-hydrazine carcinogenesis: main effect of indole-3-carbinol. J Natl Cancer Inst 77: 269–276

    PubMed  CAS  Google Scholar 

  • Phillips RL (1975) Role of life-style and dietary habits in risk of cancer among Seventh-Day Adventists. Cancer Res 35: 3513–3522

    PubMed  CAS  Google Scholar 

  • Phillips RL, Snowdon DA (1985) Dietary relationships with fatal colorectal cancer among Seventh-Day Adventists. J Natl Cancer Inst 74: 307–317

    PubMed  CAS  Google Scholar 

  • Pickle LW, Greene MH, Ziegler RG, Toledo A, Hoover R, Lynch HT, Fraumeni JF (1984) Colorectal cancer in rural Nebraska. Cancer Res 44: 363–369

    PubMed  CAS  Google Scholar 

  • Pilch SM (ed) (1987) Physiological effects and health consequences of dietary fiber. Life Sciences Research Office, Federation of American Societies for Experimental Biology, Bethesda, Maryland

    Google Scholar 

  • Potter JD, McMichael AJ (1986) Diet and cancer of the colon and rectum: a case-control study. J Natl Cancer Inst 76: 557–569

    PubMed  CAS  Google Scholar 

  • Reddy BS, Mori H (1981) Effect of dietary wheat bran and dehydrated citrus fiber on 3,2-dimethyl-4-aminobiphenyl-induced intestinal carcinogenesis in F344 rats. Carcinogenesis 2: 21–25

    Article  PubMed  CAS  Google Scholar 

  • Reddy BS, Mori H, Nicolais M (1981) Effect of dietary wheat bran and dehydrated citrus fiber on azoxymethane-induced intestinal carcinogenesis in Fischer 344 rats. J Natl Cancer Inst 66: 553–557

    PubMed  CAS  Google Scholar 

  • Reddy BS, Maeura Y, Wayman M (1983) Effect of dietary corn bran and autohydrolyzed lignin on 3,2-dimethyl-4-aminobiphenyl-induced intestinal carcinogenesis in male F344 rats. J Natl Cancer Inst 71: 419–423

    PubMed  CAS  Google Scholar 

  • Reddy BS, Sharma C, Simi B, Engle A, Laakso K, Puska P, Korpela R (1987) Metabolic epidemiology of colon cancer: effect of dietary fiber on fecal mutagens and bile acids in healthy subjects. Cancer Res 47: 644–648

    PubMed  CAS  Google Scholar 

  • Roberts-Andersen J, Mehta T, Wilson RB (1987) Reduction of DMH-induced colon tumors in rats fed psyllium husk or cellulose. Nutr Cancer 10: 129–136

    Article  PubMed  CAS  Google Scholar 

  • Roediger WEW (1982) Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 83: 424–429

    PubMed  CAS  Google Scholar 

  • Rowland IR, Wise A, Mallett AK (1983) Metabolic profile of caecal micro-organisms from rats fed indigestible plant cell-wall components. Food Chem Toxicol 21: 25–29

    Article  PubMed  CAS  Google Scholar 

  • Rozen P, Hellerstein SM, Horwitz C (1981) The low incidence of colorectal cancer in a “high risk” population: its correlation with dietary habits. Cancer 48: 2692–2695

    Article  PubMed  CAS  Google Scholar 

  • Rozen P, Horwitz C, Tabenkin C, Ron E, Katz L (1987) Dietary habits and colorectal cancerincidence in a second-defined kibbutz population. Nutr Cancer 9 (2–3): 177–184

    Article  PubMed  CAS  Google Scholar 

  • Sakata T, Yajima T (1984) Influence of short chain fatty acids on the epithelial cell division of digestive tract. Q J Exp Physiol 69: 639–648

    PubMed  CAS  Google Scholar 

  • Samelson SL, Nelson RL, Nyhus LM (1985) Protective role of fecal pH in experimental colon carcinogenesis. J R Soc Med 78: 230–233

    PubMed  CAS  Google Scholar 

  • Schrauzer GN (1976) Cancer mortality correlation studies. II. Regional association of mortali- ties with the consumptions of foods and other commodities. Med Hypotheses 2: 39–49

    Article  PubMed  CAS  Google Scholar 

  • Smith-Barbaro P, Hanson D, Reddy BS (1981) Carcinogen binding to various types of dietary fiber. J Natl Cancer Inst 67: 495–497

    PubMed  CAS  Google Scholar 

  • Stocks P, Kam MN (1933) A cooperative study of the habits, home life, dietary and family histories of 450 cancer patients and of an equal number of control patients. Ann Eugen (London) 5: 237–280

    Article  Google Scholar 

  • Story JA (1986) Modification of steroid excretion in response to dietary fiber. In: Vahouny GV, Kritchevsky D (eds) Dietary fiber. Basic and clinical aspects. Plenum, New York, pp 253–264

    Google Scholar 

  • Tajima K, Tominaga S (1985) Dietary habits and gastrointestinal cancer: A comparative case-control study of stomach and large intestinal cancers in Nagoya, Japan. Jpn J Cancer Res 76: 705–716

    Google Scholar 

  • Takada H, Hirooka T, Hiramatsu Y, Yamamoto M (1982) Effect of ß-glucuronidase inhibitor on azoxymethane-induced colonic carcinogenesis in rats. Cancer Res 42: 331–334

    PubMed  CAS  Google Scholar 

  • Temple NJ, El-Khatib S (1987) Cabbage and vitamin E: their effect on colon tumor formation in mice. Cancer Lett 35: 71–77

    Article  PubMed  CAS  Google Scholar 

  • Thornton JR (1981) High colonic pH promotes colorectal cancer. Lancet i: 1081–1083

    Google Scholar 

  • Thornton JR, Dryden A, Kelleher J, Losowsky MS (1987) Super-efficient starch absorption. A risk factor for colonic neoplasia? Dig Dis Sci 32: 1088–1091

    Article  PubMed  CAS  Google Scholar 

  • Toth B (1984) Effect of Metamucil on tumour formation by 1,2-dimethylhydrazine dihydrochloride in mice. Food Chem Toxicol 22: 573–578

    Article  PubMed  CAS  Google Scholar 

  • Trowell H (1976) Definition of dietary fiber and hypotheses that it is a protective factor in certain diseases. Am J Clin Nutr 29: 417–427

    PubMed  CAS  Google Scholar 

  • Trudel JL, Senterman MK, Brown RA (1983) The fat/fiber antagonism in experimental colon carcinogenesis. Surgery 94: 691–696

    PubMed  CAS  Google Scholar 

  • Tuyns AJ (1986) A case-control study on colorectal cancer in Belgium. Preliminary results. Soz Praventivmed 31: 81–82

    Article  PubMed  CAS  Google Scholar 

  • Walker ARP (1978) The relationship between bowel cancer and fiber content in the diet. Am J Clin Nutr 31: 5248 — S251

    Google Scholar 

  • Walker ARP, Walker BF, Walker AJ (1986) Fecal pH, dietary fibre intake, and proneness to colon cancer in four South African populations. Br J Cancer 53: 489–495

    Article  PubMed  CAS  Google Scholar 

  • Ward JM, Yamamoto RS, Weisburger JH (1973) Cellulose dietary bulk and azoxymethaneinduced intestinal cancer. J Natl Cancer Inst 51: 713–715

    PubMed  CAS  Google Scholar 

  • Wargovich MJ, Eng VWS, Newmark HL (1984) Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett 23: 253–258

    Article  PubMed  CAS  Google Scholar 

  • Watanabe K, Reddy BS, Wong CQ, Weisburger JH (1978) Effect of dietary undegraded carageenan on colon carcinogenesis in F344 rats treated with azoxymethane or methylnitrosourea. Cancer Res 38: 4427–4430

    PubMed  CAS  Google Scholar 

  • Watanabe K, Reddy BS, Weisburger JH, Kritchevsky D (1979) Effect of dietary alfalfa, pectin and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats. J Natl Cancer Inst 63: 141–145

    PubMed  CAS  Google Scholar 

  • Weisburger JH, Reddy BS, Barnes MS, Wynder EL (1983) Bile acids but not neutral sterols, are tumor promoters in the colon in man and in rodents. Environ Health Perspect 50: 101–107

    Article  PubMed  CAS  Google Scholar 

  • Wilpart M, Roberfroid M (1987) Intestinal carcinogenesis and dietary fibers: the influence of cellulose on Fybogel chronically given after exposure to DMH. Nutr Cancer 10: 39–51

    Article  PubMed  CAS  Google Scholar 

  • Wilson RB, Hutcheson DP, Wideman L (1977) Dimethylhydrazine-induced colon tumors in rats fed diets containing beef fat or corn oil with and without wheat bran. Am J Clin Nutr 30: 176–181

    PubMed  CAS  Google Scholar 

  • Wynder EL, Shigematsu T (1967) Environmental factors of cancer of the colon and rectum. Cancer 20: 1520–1561

    Article  PubMed  CAS  Google Scholar 

  • Wynder EL, Kajitani T, Ishikawa S, Dodo H, Takano A (1969) Environmental factors of cancerof the colon and rectum. II. Japanese epidemiological data. Cancer 23: 1210–1220

    Google Scholar 

  • Yamamoto I, Marugama H (1985) Effect of dietary seaweed preparations on 1,2-dimethyl-hydrazine-induced intestinal carcinogenesis in rats. Cancer Lett 26: 241–251

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Nutrition, Division of Gastroenterology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California, 90048, USA

    L. R. Jacobs

Authors
  1. L. R. Jacobs
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Innere Medizin IV (Gastroenterologie), Medizinische Universitätsklinik, Bergheimer Straße 58, D-6900, Heidelberg 1, Germany

    Helmut Karl Seitz  & Ulrich A. Simanowski  & 

  2. Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK

    Nicholas A. Wright

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Jacobs, L.R. (1989). Dietary Fiber, Fiber-Containing Foods, and Colon Cancer Risk. In: Seitz, H.K., Simanowski, U.A., Wright, N.A. (eds) Colorectal Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85930-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85930-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85932-8

  • Online ISBN: 978-3-642-85930-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation