Skip to main content
SpringerLink
Log in

Dietary Fat and Colorectal Cancer: Experimental Evidence for Tumor Promotion

  • Chapter
Colorectal Cancer

Abstract

Investigations into colorectal cancer during the past three decades have suggested that genetic variation accounts for only a small percentage of the approximately 500000 new cases of this type of cancer worldwide each year (Muir and Parkin 1985). It is becoming more apparent that environmental factors, particularly dietary constituents, are important and are causally implicated in a significant percentage of colorectal cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • American Institute of Nutrition (1977) Report of the AIN ad hoc committee on standards for nutritional studies. J Nutr 107: 1340–1348

    Google Scholar 

  • Armstrong B, Doll R (1975) Environmental factors and cancer incidence and mortality in different countries with special reference to dietary practices. Int J Cancer 15: 617–631

    Article  PubMed  CAS  Google Scholar 

  • Autrup H, Williams GM (1983) Carcinogenesis studies in human gastrointestinal epithelium. In: Autrup H, Williams GM (eds) Experimental colon carcinogenesis. CRC, Boca Raton, pp 95–106

    Google Scholar 

  • Bansal BR, Rhoads JE, Bansal SC (1978) Effects of diet on colon carcinogenesis and the immune system in rats treated with 1,2-dimethylhydrazine. Cancer Res 38: 3293–3303

    PubMed  CAS  Google Scholar 

  • Bingham S, Williams DRR, Cole TJ, James WPT (1979) Dietary fibre and regional large-bowel cancer mortality in Britain. Br J Cancer 40: 456–463

    Article  PubMed  CAS  Google Scholar 

  • Bjelke E (1978) Dietary factors and the epidemiology of cancer of the stomach and large bowel. Aktuel Ernaehrungsmed KIM Prax (Suppl 2 ): 10–17

    Google Scholar 

  • Bland PW, Britton DC (1984) Morphological study of antigen-sampling structures in the rat large intestine. Infect Immun 43: 693–699

    PubMed  CAS  Google Scholar 

  • Broitman SA (1981) Cholesterol excretion and colon cancer. Cancer Res 41: 3738–3740

    PubMed  CAS  Google Scholar 

  • Broitman SA, Vitale JJ, Vavrousek-Jakuba E, Gottlieb LS (1977) Polyunsaturated fat, cholesterol and large bowel tumorigenesis. Cancer 40: 2455–2463

    Article  PubMed  CAS  Google Scholar 

  • Bull AW, Soullier BK, Wilson PS, Hayden MT, Nigro ND (1979) Promotion of azoxymethaneinduced intestinal cancer by high-fat diet in rats. Cancer Res 39: 4956–4959

    PubMed  CAS  Google Scholar 

  • Bull AW, Burd AD, Nigro ND (1981) Effect of inhibitors of tumorigenesis on the formation of 06-methylguanine in the colon of 1,2-dimethylhydrazine-treated rats. Cancer Res 41: 4938 —4941

    Google Scholar 

  • Byers T, Graham S (1984) The epidemiology of diet and cancer. In: Klein G, Weinhouse S (eds) Advances in Cancer Research. Academic, New York, pp 1–16

    Google Scholar 

  • Cancer Statistics (1986) Ca-A Cancer journal for clinicians. American Cancer Society, New York, 36: 16–27

    Google Scholar 

  • Celik C, Mittelman A, Paolini NS, Lewis D, Evans JT (1981) Effects of 1,2-symmetrical dimethyl- hydrazine on jejunocolic transposition in Sprague-Dawley rats. Cancer Res 41: 2908–2911

    PubMed  CAS  Google Scholar 

  • Cohen B, Racht RF, Faccini E (1982) Reduction N-nitrosourea induced colon tumors in the rat by cholesterol. Cancer Res 42: 5050–5052

    PubMed  CAS  Google Scholar 

  • Committee on Diet, Nutrition, and Cancer (1982) Assembly of Life Sciences. National Research Council. Diet, nutrition, and cancer. National Academy Press, Washington

    Google Scholar 

  • Cooper HK, Buecheler J, Kleihues P (1978) DNA alkylation in mice with genetically different susceptibility. Cancer Res 38: 3063–3065

    PubMed  CAS  Google Scholar 

  • Cummings JH (1983) Fermentation in the human large intestine: evidence and implications for health. Lancet 1: 1206–1211

    Article  PubMed  CAS  Google Scholar 

  • Dales LG, Friedman GD, Ury HK, Grossman S, Williams SR (1978) A case-control study of relationships of diet and other traits to colorectal cancer in American Blacks. Am J Epidemiol 109:132 —144

    Google Scholar 

  • Devroede G, Winawer S, Schottenfield D, Sherlock P (eds) (1980) Risk of cancer in inflammatory bowel disease. In: Colorectal cancer: prevention, epidemiology and screening. Raven, New York, pp 325–344

    Google Scholar 

  • Doll R, Peto R (1981) The causes of cancer. Oxford University Press, Oxford

    Google Scholar 

  • Donato K, Hegsted DM (1985) Efficiency of utilization of various sources of energy for growth. Proc Natl Acad Sci USA 82: 4866–4870

    Article  PubMed  CAS  Google Scholar 

  • Druckrey H, Preussman S, Ivanbovic D, Schmahl J, Afbham G, Blum HD, Mennel M, Muller M, Petropoulos P, Schneider H (1967) Organotropic carcinogenic effects of 65 different N-nitroso compounds on BD rats. Z Krebsforsch 69: 103–201

    Article  PubMed  CAS  Google Scholar 

  • El Khatib SM, Cora EM (1981) Role of high fat diet in tumorigenesis in C57BL/1 mice. JNCI 66: 297–301

    PubMed  Google Scholar 

  • Enstrom JE (1975) Colorectal cancer and consumption of beef and fat. Br J Cancer 32: 432–439

    Article  PubMed  CAS  Google Scholar 

  • Fisher ER, Paulson J, McCoy M (1981) Genesis of 1,2-dimethylhydrazine-induced colon cancer. Arch Pathol Lab Med 105: 29–37

    PubMed  CAS  Google Scholar 

  • Garmaise ABK, Rogers AE, Saravis C, Zamcheck N, Newberne P (1975) Immunologic aspects of 1,2-dimethylhydrazine-induced colon tumors in rats. J Natl Cancer Inst 54: 1231–1235

    PubMed  CAS  Google Scholar 

  • Gennaro AR, Villanueva R, Sukonthaman Y, Vathanopas V, Rosemond GP (1973) Chemical carcinogenesis in transposed intestinal segments. Cancer Res 33: 536–541

    PubMed  CAS  Google Scholar 

  • Goldin B, Gorbach SL (1981) Effect of antibiotics on rat intestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. J Natl Cancer Inst 67: 877–880

    PubMed  CAS  Google Scholar 

  • Goldin B, Gorbach SL (1983) Activation of carcinogens by bacterial and microsomal enzyme systems. Gastroenterology 85: 200–201

    PubMed  CAS  Google Scholar 

  • Gortner WA (1975) Nutrition in the United States 1900–1974. Cancer Res 35: 3246–3253

    PubMed  CAS  Google Scholar 

  • Graham S, Dayal H, Swanson M, Mittleman A, Wilkinson G (1978) Diet in the epidemiology of cancer of the colon and rectum. J Natl Cancer Inst 61: 709–714

    PubMed  CAS  Google Scholar 

  • Haenszel W, Berg JW, Segi M, Krihara M Locke FB (1973) Large-bowel cancer in Hawaiian Japanese. J Natl Cancer Inst 51: 1765–1779

    PubMed  CAS  Google Scholar 

  • Haenszel W, Locke FB, Segi M (1980) A case-control study of large bowel cancer in Japan. J Natl Cancer Inst 64: 17–22

    PubMed  CAS  Google Scholar 

  • Hawks A, Magee DM (1974) The alkylation of nucleic acids in the rat and mouse in vivo by the carcinogen 1,2-dimethylhydrazine. Br J Cancer 30: 440–447

    Article  PubMed  CAS  Google Scholar 

  • Hill MJ et al. (1987) Faecal bile acids, dysplasia and carcinoma in ulcerative colitis. Lancet ii: 185–186

    Google Scholar 

  • Howell MA (1975) Diet as an etiological factor in the development of cancers of the colon and rectum. J Chronic Dis 29: 67–80

    Article  Google Scholar 

  • Isaksson G, Lundquist I, Akesson B, Ihse I (1984) Effect of pectin and wheat bran on intraluminal pancreatic enzyme activities and on fat absorption as examined with the triolein breath test in patients with pancreatic insufficiency. Scand J Gastroenterol 19: 457–473

    Google Scholar 

  • Jacobs MM (1983) Selenium inhibition of 1,2-dimethylhydrazine-induced colon carcinogenesis. Cancer Res 43: 1646–1649

    PubMed  CAS  Google Scholar 

  • James JT, Autrup H (1983) Methylated DNA adducts in the large intestine of ICR/HA and C57BL/HA mice given 1,2-dimethylhydrazine. J Natl Cancer Inst 70: 541–546

    PubMed  CAS  Google Scholar 

  • Kaur AP, Bhat CM, Grewal RB (1985) Effect of cellulose incorporation in a low fiber diet on fecal excretion and digestibility of nutrients in adolescent girls. Nutr Rep Int 32: 383–390

    Google Scholar 

  • Knox EG (1977) Foods and diseases. Br J Prey Soc med 31: 71–80

    CAS  Google Scholar 

  • Kolonel LN, Marchand LL (1986) The epidemiology of colon cancer and dietary fat. In: Ip C, Birt DF, Rogers AE, Metlin C (eds) Dietary fat and cancer. Liss, New York, pp 69–92

    Google Scholar 

  • Lightdale CJ, Sherlock P (1980) Cancer in Crohn’s disease: Memorial Hospital experience and review of the literature. In: Winawar S, Schottenfeld D, Sherlock P (eds) Colorectal cancer: prevention, epidemiology, and screening. Raven, New York, pp 341–346

    Google Scholar 

  • Locniskar M, Nauss KM, Kaufmann P, Newberne PM (1975) Interaction of dietary fat and route of carcinogen administration on 1,2 DMH-induced colon tumorigenesis in rats. Carcinogenesis 6: 349–354

    Article  Google Scholar 

  • Lyon JL, Sorenson AW (1978) Colon cancer in a low-risk population. Am J Clin Nutr 31: 5227 — 5230

    Google Scholar 

  • Madara JL, Harte P, Deasey J et al. (1983) Evidence for adenoma carcinoma progression in DMH-induced rat neoplasm. Am J Pathol 110: 230–235

    PubMed  CAS  Google Scholar 

  • Maskens AP (1980) Confirmation of the two-step nature of chemical carcinogenesis in the rat colon adenocarcinoma model. Cancer Res 41: 1240–1245

    Google Scholar 

  • Maskens AP, Dujardins-Loits R (1981) Experimental adenomas and carcinomas of the large intestine behave as distinct entities: most carcinomas arise de novo in flat mucosa. Cancer 47:81— 89

    Google Scholar 

  • Morson BC (1980) Use of dysplasia as an indicator of risk for malignancy in patients with ulcerative colitis. In: Winawer S, Schottenfeld D, Sherlock P (eds) Colorectal cancer: prevention, epidemiology, and screening. Raven, New York, pp 341–346

    Google Scholar 

  • Muir CS, Parkin DM (1985) The world cancer burden: prevent on perish. Br Med J 1: 5–6

    Article  Google Scholar 

  • Narisawa T, Weisburger JH (1975) Colon cancer induction in mice by intrarectal instillation of N-methylnitrosourea. Proc Soc Exp Biol Med 148: 166–172

    PubMed  CAS  Google Scholar 

  • Narisawa T, Sata M, Tani M, Kudo T, Takahashi T, Goto A (1981) Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment. Cancer Res 41:1954 —1957

    Google Scholar 

  • Nauss KM, Locniskar M, Newberne PM (1983) Effects of alterations in quantity and quality of dietary fat on 1,2-DMH-induced colon tumorigenesis in rats. Cancer Res 43: 4083–4090

    PubMed  CAS  Google Scholar 

  • Nauss KM, Locniskar M, Pavlina T, Newberne PM (1984a) Morphology and distribution of 1,2-dimethylhydrazine dihydrochloride-induced colon tumors and their relationship to gut-associated lymphoid tissue in the rat. J Natl Cancer Inst 73: 915–924

    PubMed  CAS  Google Scholar 

  • Nauss KM, Locniskar M, Sondergaard D, Newberne PM (1984b) Lack of effect of dietary fat on N-nitrosomethylurea ( NMU)-induced colon tumorigenesis in rats. Carcinogenesis 5: 255–260

    Google Scholar 

  • Nauss KM, Jacobs LR, Newberne PM (1986) Dietary fat and fiber: relationship to caloric intake, body growth, and colon tumorigenesis. Am J Clin Nutr 45 (Suppl 1): 149–372

    Google Scholar 

  • Nauss KM, Bueche D, Newberne PM (1987) Effect of beef fat on DMH-induced colon tumorigenesis: influence of rat strain and nutrient composition. J Nutr 117: 739–747

    PubMed  CAS  Google Scholar 

  • Newberne PM, Nauss KM (1986) Dietary fat and colon cancer: variable results in animal models. In: Ip C, Birt DF, Rogers AE, Mettlin C (eds) Dietary fat and cancer. Liss, New York, pp 311–330

    Google Scholar 

  • Newberne PM, Suphakarn V (1977) Preventive role of vitamin A in colon carcinogenesis in rats. Cancer 40: 2553–2556

    Article  PubMed  CAS  Google Scholar 

  • Newberne PM, Young VR (1973) Marginal maternal vitamin B12: long term effects. Nature 242: 263 — 270

    Google Scholar 

  • Nigro ND, Bhadrachari N, Chomchai C (1973) A rat model for studying colon cancer. Effect of cholestyramine on induced tumors. Dis Colon Rectum 16: 438–443

    Google Scholar 

  • Nigro ND, Sigh DV, Campbell RL, Pak MS (1975) Effect of dietary fat on intestinal tumors. J Natl Cancer Inst 54: 439–442

    PubMed  CAS  Google Scholar 

  • Notman J, Tan QH, Zedeck MS (1982) Inhibition of methylazoxymethanol-induced intestinal tumors in the rat by pyrazole with paradoxical effects on skin and kidney. Cancer Res 42: 1774–1780

    PubMed  CAS  Google Scholar 

  • Nutter RL, Gridley DS, Kettering JD, Goude AG, Slater JM (1983) BALB/c mice fed milk or beef protein. JNCI 71: 867–875

    PubMed  CAS  Google Scholar 

  • Nyman M, Asp N-G (1982) Fermentation of dietary fiber components in the rat intestinal tract. Br J Nutr 47: 357–364

    Article  PubMed  CAS  Google Scholar 

  • Phillips RL (1975) Role of life-style and dietary habits in risk of cancer among Seventh-Day Adventists. Cancer Res 35: 3513–3522

    PubMed  CAS  Google Scholar 

  • Pollard M, Luckert P (1980) Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors. Cancer Treat Rep 64: 1323–1327

    PubMed  CAS  Google Scholar 

  • Pozharisski KM, Likhachev A, Klimashevski V, Shaposhnikov J (1979) Experimental intestinal cancer research with special reference to human pathology. Adv Cancer Res 30: 165–237

    Article  PubMed  CAS  Google Scholar 

  • Reddy BS (1979) Nutrition and colon cancer. Adv Nutr Res 2: 199–218

    CAS  Google Scholar 

  • Reddy BS, Weisburger JH, Wynder EL (1974) Effects of dietary fat level and dimethylhydrazine on fecal acid and neutral sterol excretion and colon carcinogenesis in rats. J Natl Cancer Inst 52: 507–511

    PubMed  CAS  Google Scholar 

  • Reddy BS, Watanabe K, Weisburger JH (1977a) Effect of high-fat diet on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine, methylazoxymethanol acetate, or methylnitrosourea. Cancer Res 37: 4156–4159

    PubMed  CAS  Google Scholar 

  • Reddy BS, Watanabe K, Weisburger JH, Wynder EL (1977b) Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats. Cancer Res 37: 3238–3242

    PubMed  CAS  Google Scholar 

  • Reddy BS, Cohen LA, McCoy GD, Hill P, Weisburger JH, Wynder EL (1980) Nutrition and its relationship to cancer. Adv Cancer Res 32: 237–345

    Article  PubMed  CAS  Google Scholar 

  • Reddy BS, Ohmori T (1981) Effect of intestinal microflora and dietary fat on colon carcinogenesis in F344 rats. Cancer Res 451: 1363–1367

    Google Scholar 

  • Reddy BS (1986) Amount and type of dietary fat and colon cancer: animal model studies. In: 1p C, Birt DF, Rogers AE, Mettlin C (eds) Dietary fat and cancer. Liss, New York, pp 295–309

    Google Scholar 

  • Rogers AE (1975) Variable effects of a lipotrope-deficient, high-fat diet on chemical carcinogenesis in rats. Cancer Res 35: 2469–2474

    PubMed  CAS  Google Scholar 

  • Rogers AE, Gildin J (1975) Effect of BCG on dimethylhydrazine induction of colon tumors in rats. J Natl Cancer Inst 55: 385–391

    PubMed  CAS  Google Scholar 

  • Rogers AE, Newberne PM (1973) Dietary enhancement of intestinal carcinogenesis by dimethylhydrazine in rats. Nature 246: 491–492

    Article  PubMed  CAS  Google Scholar 

  • Rogers AE, Newberne PM (1980) Lipotrope deficiency in experimental carcinogenesis. Nutr Cancer 2: 104–112

    Article  CAS  Google Scholar 

  • Rogers KJ, Pegg AE (1977) Formation of 06-methylguanine by alkylation of rat liver, colon, and kidney DNA following administration of 1,2-dimethylhydrazine. Cancer Res 37: 4082–4087

    PubMed  CAS  Google Scholar 

  • Rogers AE, Herndon BJ, Newberne PM (1973) Induction by dimethylhydrazine of intestinal carcinoma in normal rats and rats fed high or low level of vitamin A. Cancer Res 33:1003 —1009

    Google Scholar 

  • Rubio CA, Nylander G (1981) Further studies on the carcinogenesis of the colon and the rat with special reference to the absence of intestinal contents. Cancer 48: 951–953

    Article  PubMed  CAS  Google Scholar 

  • Shamsuddin AKM (1983) In vivo induction of colon cancer: dose and animal species. In: Autrup H, Williams GM (eds) Experimental colon carcinogenesis. CRC, Boca Raton, pp 51–79

    Google Scholar 

  • Shamsuddin AKM, Trump BF (1983) Colon epithelium. II. In vivo studies of colon carcinogenesis. Light microscopic, histochemical, and ultrastructural studies of histogenesis of azoxymethane-induced colon carcinomas in Fischer 344 rats. J Natl Cancer Inst 66: 389–401

    Google Scholar 

  • Sinclair TS, Brunt PW, Mowat NA (1983) Nonspecific proctocolitis in northeastern Scotland: a community study. Gastroenterology 85: 1–11

    PubMed  CAS  Google Scholar 

  • Stemmerman GN, Nomura AM, Heilbrun LK (1984) Dietary fat and the risk of colorectal cancer. Cancer Res 44: 4633–4637

    Google Scholar 

  • Stemmerman GN, Nomura AM, Heilbrun LK (1986) Cancer risk in relation to fat and energy intake among Hawaiian Japanese. A prospective study. In: Hayashi Y, Nagoo M, Sugimura T et al. (eds) Diet, nutrition and cancer. Japan Scientific Society Press, Tokyo, pp 265–274

    Google Scholar 

  • Swenberg JA, Cooper HK, Bucheler J, Kleihues P (1979) 1,2-Dimethylhydrazine-induced methylation of DNA bases in various rat organs and the effect of pretreatment with disulfiram. Cancer Res 39: 465–467

    Google Scholar 

  • Toth B, Patil K (1983) Enhancing effect of vitamin E on murine intestinal tumorigenesis by 1,2-dimethylhydrazine dihydrochloride. J Natl Cancer Inst 70: 1107–1111

    CAS  Google Scholar 

  • Visek WJ, Clinton SK (1983) Dietary fat and breast cancer. In: Perkins EG,Visek WJ (eds) Dietary fats and health. American Oil Chemists Society, Champaign, IL, pp 721–728

    Google Scholar 

  • Ward JM (1974) Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats. Lab Invest 30: 505–513

    PubMed  CAS  Google Scholar 

  • Ward JM, Yamamoto RS, Brown CA (1973) Pathology of intestinal neoplasms and other lesions in rats exposed to azoxymethane. J Natl Cancer Inst 51: 1029–1039

    PubMed  CAS  Google Scholar 

  • Wargovich MJ, Medline A, Bruce WR (1983) Early histopathologic events of evolution of colon cancer in C57BL/6 and CF1 mice treated with 1,2-dimethylhydrazine. J Natl Cancer Inst 71: 125–131

    PubMed  CAS  Google Scholar 

  • Wattenberg LW (1983) Inhibition of neoplasia by minor dietary constituents. Cancer Res 43 (Suppl): 2448–2453

    CAS  Google Scholar 

  • Weisburger JH, Fiala ES (1983) Experimental colon carcinogenesis and their mode of action. In: Autrup H, Williams GM (eds) Experimental colon carcinogenesis. CRC, Boca Raton, pp 27–50

    Google Scholar 

  • Williamson RCN, Bauer FLR, Terpstra OT, Ross JS, Malt RA (1980) Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on azoxymethane-induced intestinal carcinogenesis. Cancer Res 40: 538–543

    PubMed  CAS  Google Scholar 

  • Yardley JH, Ransohoff D, Riddell RH, Goldman H (1983) Incidence of inflammatory bowel disease: going up or down? Gastroenterology 85: 196–203

    Google Scholar 

  • Zedeck MS, Tan Q (1978) P-effect of pyrazole in tumor induction by MAM. Pharmacologist 20: 174–181

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Boston University School of Medicine, 784 Massachusetts Ave., Boston, MA, 02118, USA

    P. M. Newberne

  2. Department of Pathobiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand

    S. Sahaphong

Authors
  1. P. M. Newberne
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Sahaphong
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Innere Medizin IV (Gastroenterologie), Medizinische Universitätsklinik, Bergheimer Straße 58, D-6900, Heidelberg 1, Germany

    Helmut Karl Seitz  & Ulrich A. Simanowski  & 

  2. Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK

    Nicholas A. Wright

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Newberne, P.M., Sahaphong, S. (1989). Dietary Fat and Colorectal Cancer: Experimental Evidence for Tumor Promotion. In: Seitz, H.K., Simanowski, U.A., Wright, N.A. (eds) Colorectal Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85930-4_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85930-4_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85932-8

  • Online ISBN: 978-3-642-85930-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation