Advertisement

Biochemical Changes in Colorectal Carcinogenesis

  • N. W. Toribara
  • S. B. Ho
  • R. S. Bresalier
  • Y. S. Kim
Chapter

Abstract

Technological advances over the past decade have produced a remarkable expansion in our knowledge of the basic biological processes involved in cell growth and replication. Nevertheless, our understanding of these processes both under normal and pathological circumstances is far from complete and, in fact, can be considered to be early in its evolution.

Keywords

Adenomatous Polyp Colorectal Carcinogenesis Familial Polyposis Blood Group Antigen Human Colonic Adenocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abe K, McKibbin JM, Hakomori S (1983) The monoclonal antibody directed to difucosylated type 2 chain (Fucαl → 2 Galß1 →4 [Fucαl → 3] G1cNAc; Y determinant). J Biol Chem 258:11 793–11 797Google Scholar
  2. Abe K, Hakomori S, Ohshiba S (1986) Differential expression of difucosyl type 2 chain (Ley) defined by monoclonal antibody AH6 in different locations of colonic epithelia, various histological types of colonic polyps, and adenocarcinomas. Cancer Res 46: 2639–2644PubMedGoogle Scholar
  3. Abeloff MD, Rosen ST, Luk GD, Baylin SB, Zeltzman M, Sjoerdsma A (1986) Phase II trials of a-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer. Cancer Treat Rep 70: 843–845PubMedGoogle Scholar
  4. Allfrey VG, Boffa LC, Vidali G (1977) Selective inhibition with sodium cyanate of protein synthesis in colon cancer cells. Cancer 40: 2692–2698PubMedCrossRefGoogle Scholar
  5. Arends JW, Verstynen C, Bosman FT, Hilgers J, Steplewski Z (1983) Distribution of monoclonal antibody-defined monosialoganglioside in normal and cancerous human tissues: an immunoperoxidase study. Hybridoma 2: 219–229PubMedCrossRefGoogle Scholar
  6. Armitage NC, Robins RA, Evans DF, Turner DR, Baldwin RW, Hardcastle JD (1985) The influence of tumour cell DNA abnormalities on survival in colorectal cancer. Br J Surg 72: 828–830PubMedCrossRefGoogle Scholar
  7. Atkinson BF, Ernst CS, Herlyn M, Steplewski Z, Sears HF, Koprowski H (1982) Gastrointestinal cancer-associated antigen in immunoperoxidase assay. Cancer Res 42: 4820–4823PubMedGoogle Scholar
  8. Balis ME, Higgins PJ, Salser JS (1981) Enzymes of normal, premalignant, and malignant colonic cells. In: Bruce WR, Correa P, Lipkin M, Tannenbaum SR, Wilkins TD (eds) Banbury report no 7: Gastrointestinal cancer: endogenous factors. Cold Spring Harbor, New York, pp 129–139Google Scholar
  9. Bara J, Nardelli J, Gadenne C, Prade M, Bertin P (1984) Differences in the expression of mucus-associated antigens between proximal and distal human colon adenocarcinomas. Br J Cancer 49: 495–501PubMedCrossRefGoogle Scholar
  10. Bara J, Gautier R, Daher N, Zaghouani H, Decaens C (1986) Monoclonal antibodies against oncofetal mucin M1 antigens associated with precancerous colonic mucosae. Cancer Res 46: 3983–3989PubMedGoogle Scholar
  11. Basu A, Murthy U, Rodeck U, Herlyn M, Mattes L, Das M (1987) Presence of tumor-associated antigens in epidermal growth factor receptors from different human carcinomas. Cancer Res 47: 2531–2536PubMedGoogle Scholar
  12. Bauer KD, Clevenger CV, Endow RK, Murad T, Epstein AL, Scarpelli DG (1986) Simultaneous nuclear antigen and DNA content quantitation using paraffin-embedded colonic tissue and multiparameter flow cytometry. Cancer Res 46: 2428–2434PubMedGoogle Scholar
  13. Becher R, Gibas Z, Sandberg AA (1983) Involvement of chromosomes 7 and 12 in large bowel cancer: trisomy 7 and 12q-. Cancer Genet Cytogenet 8: 329–332CrossRefGoogle Scholar
  14. Bertram JS, Mordan LJ, Domanska-Janik K, Bernacki RJ (1982) Inhibition of in vitro neoplastic transformation by retinoids. In: Arnott MS, Van Eys J, Wang YM (eds) Molecular interrelations of nutrition and cancer. Raven, New York, pp 315–335Google Scholar
  15. Bloom EJ, Itzkowitz SH, Kim YS (in press) Carbohydrate tumor markers in colon cancer and polyps. In: Moyer MP, Posk GH (eds) Colon cancer cells. Academic, New YorkGoogle Scholar
  16. Bodmer WF, Bailey CJ, Bodmer J, Bussey HJR, Ellis A, Gorman P, Lucibello FC, Murday VA, Rider SH, Scambler P, Sheer D, Solomon E, Spurr NK (1987) Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 328: 614–616PubMedCrossRefGoogle Scholar
  17. Boffa LC, Allfrey VG (1977) Changes in chromosomal proteins in colon cancer. Cancer 40: 2584–2591PubMedCrossRefGoogle Scholar
  18. Boffa LC, Diwan BA, Gruss R, Allfrey VG (1980) Differences in colonic nuclear proteins of two mouse strains with different susceptibilities to 1,2-dimethylhydrazine-induced carcinogenesis. Cancer Res 40: 1774–1780PubMedGoogle Scholar
  19. Boffa LC, Kozak S, Allfrey VG (1981) Activation of sodium cyanate for selective inhibition of protein synthesis in cultured tumor cells. Cancer Res 41: 60–66PubMedGoogle Scholar
  20. Boland CR, Ahnen DJ (1985) The binding of lesions to goblet cell mucin in premalignant colonic epithelium of the CF-1 mouse. Gastroenterology 89: 127–137PubMedGoogle Scholar
  21. Boland CR, Clapp NK (1987) Glycoconjugates in the colon of new world monkeys with spontaneous colitis. Gastroenterology 92: 625–634PubMedGoogle Scholar
  22. Boland CR, Montgomery CK, Kim YS (1982 a) Alterations in human colonic mucin occurring with cellular differentiation and malignant transformation. Proc Natl Acad Sci USA 79: 2051–2055Google Scholar
  23. Boland CR, Montgomery CK, Kim YS (1982 b) A cancer-associated mucin alteration in benign colonic polyps. Gastroenterology 82: 664–672Google Scholar
  24. Bos JL, Fearon ER, Hamilton SR, Verlaan-de Vries M, van Boom JH, van der Eb AJ, Vogelstein B (1987) Prevalence of ras gene mutations in human colorectal cancers. Nature 327: 293–297PubMedCrossRefGoogle Scholar
  25. Bradley SJ, Garfinkle G, Walker E, Salem R, Chen LB, Steele G (1986) Increased expression of the epidermal growth factor receptor on human colon carcinoma cells. Arch Surg 121: 1242–1247PubMedCrossRefGoogle Scholar
  26. Brasitus TA, Dudeja PK, Dahiya R (1986) Premalignant alteration in the lipid composition and fluidity of colonic brush border membranes of rats administered 1,2-dimethylhydrazine. J Clin Invest 77: 831–840PubMedCrossRefGoogle Scholar
  27. Brattain MG, Kimball PM, Pretlow TG (1977) ß-hexosaminidase isoenzymes in human colonic carcinoma. Cancer Res 37: 731–735PubMedGoogle Scholar
  28. Brattain MG, Green C, Kimball PM, Marks M, Khaled M (1979) Isoenzymes of ß-hexosaminidase from normal rat colon and colonic carcinoma. Cancer Res 39: 4083–4090PubMedGoogle Scholar
  29. Brattain MG, Levine AE, Chakrabarty S, Yeoman LC, Willson JK, Long B (1984) Heterogeneity of human colon carcinoma. Cancer Metastasis Rev 3: 177–191PubMedCrossRefGoogle Scholar
  30. Bresalier RS, Boland CR, Kim YS (1984) Characteristics of colorectal carcinoma cells with high metastatic potential. Gastroenterology 87: 115–122PubMedGoogle Scholar
  31. Bresalier RS, Boland CR, Kim YS (1985) Regional differences in normal and cancer-associated glycoconjugates of the human colon. J Natl Cancer Inst 75: 249–260PubMedGoogle Scholar
  32. Bresalier RS, Hujanen ES, Raper SE, Roll FJ, Itzkowitz SH, Martin GR, Kim YS (1987 a) An animal model for colon cancer metastasis: establishment and characterization of murine cell lines with enhanced liver-metastasizing ability. Cancer Res 47: 1398–1406Google Scholar
  33. Bresalier RS, Raper SE, Hujanen ES, Kim YS (1987 b) A new animal model for human colon cancer metastasis. Int J Cancer 39: 625–630Google Scholar
  34. Bristol JB, Ghatei MA, Smith JHF, Bloom SR, Williamson RCN (1987) Elevated plasma enteroglucagon alone fails to alter distal colonic carcinogenesis in rats. Gastroenterology 92: 617–624PubMedGoogle Scholar
  35. Burtin P, Chavanel G, Andre J (1985) The plasmin system in human colonic tumors: an immunofluorescence study. Int J Cancer 35: 307–314PubMedCrossRefGoogle Scholar
  36. Burtin P, Chavanel G, Andre-Bougaran J, Gentile A (1987) The plasmin system in human adenocarcinomas and their metastases. A comparative immunofluorescence study. Int J Cancer 39: 170–178Google Scholar
  37. Cajot J-F, Sordat B, Kruithof E, Bachman F ( 1986 a) Human primary colon carcinomas xenografted into nude mice. I. Characterization of plasminogen activators expressed by primary tumors and their xenografts. J Natl Cancer Inst 77: 703–712Google Scholar
  38. Cajot J-F, Sordat B, Bachman F ( 1986 b) Human primary colon carcinomas xenografted into nude mice. II. Modulation of tumor plasminogen activator activity by the host tissue environment. J Natl Cancer Inst 77: 1099–1107Google Scholar
  39. Chakrabarty S, Jan Y, Miller CA, Brattain MG (1985) Selective nuclear protein phospho- rylation/dephosphorylation in subpopulations of human colonic carcinoma cells. Cancer Lett 28: 291–297PubMedCrossRefGoogle Scholar
  40. Chen LB, Rosenberg S, Nadakavukaren KK, Walker ES, Shepherd EL, Steele GD (1985) The cytoskeleton. In: Springer TA (ed) Hybridoma technology and the biosciences and medicine. Plenum, New York, pp 251–268CrossRefGoogle Scholar
  41. Chesa PG, Rettig WJ, Melamed MR (1986) Expression of cytokeratins in normal and neoplastic colonic epithelial cells. Implications for cellular differentiation and carcinogenic. Am J Surg Pathol 10: 829–835Google Scholar
  42. Coffey RJ, Shipley GD, Moses HL (1986) Production of transforming growth factors by human colon cancer lines. Cancer Res 46: 1164–1169PubMedGoogle Scholar
  43. Cooper D, Schermer A, Sun T-T (1985) Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations. Lab Invest 52: 243–256PubMedGoogle Scholar
  44. Cordon-Cardo C, Lloyd KO, Sakamoto J, McGroarty ME, Old LJ, Melamed MR (1986) Immunohistologic expression of blood group antigens in normal human gastrointestinal tract and colonic carcinoma. Int J Cancer 37: 667–676PubMedCrossRefGoogle Scholar
  45. Czernobilsky B, Tsou KC (1968) Adenocarcinoma, adenomas and polyps of the colon. Cancer 21: 165–177PubMedCrossRefGoogle Scholar
  46. Dahiya R, Dudeja PK, Brasitus TA (1987) Premalignant alterations in the glycosphingolipid composition of colonic epithelial cells of rats treated with 1,2-dimethylhydrazine. Cancer Res 47: 1031–1035PubMedGoogle Scholar
  47. Denk H, Holzner JH, Obiditsch-Mayr I (1975) Epithelial blood group antigens in colon polyps. I. Morphologic distribution and relationship to differentiation. J Natl Cancer Inst 54: 1313–1317Google Scholar
  48. Denk H, Tappeiner G, Holzner JH (1974) Blood group substances as carcinofetal antigens in carcinomas of the distal colon. Eur J Cancer 10: 487–490PubMedGoogle Scholar
  49. DeRubertis FR, Chayoth R, Field JB (1976) The content and metabolism of cyclic adenosine 3’,5’-monophosphate and cyclic guanosine 3’,5’-monophosphate in adenocarcinoma of the human colon. J Clin Invest 57: 641–649PubMedCrossRefGoogle Scholar
  50. DeRubertis FR, Craven PA (1980) Early alterations in rat colonic mucosal cyclic nucleotide metabolism and protein kinase activity induced by 1,2-dimethylhydrazine. Cancer Res 40: 4589–4598PubMedGoogle Scholar
  51. DiFronzo G, Cappelletti V, Miodini P, Bertario L, Ravasi G (1987) Role of cellular retinoic acid binding protein (cRABP) in patients with large bowel cancer. Cancer Detect Prey 10: 327–333Google Scholar
  52. d’Istria M, Fasano S, Catuogno F, Gaeta F, Bucci L, Benassal G, Mazzeo F, Delrio G (1986) Androgen and progesterone receptors in colonic and rectal cancers. Dis Colon Rectum 29: 263–265PubMedCrossRefGoogle Scholar
  53. Dutrillaux B, Muleris M (1986) Induction of increased salvage pathways of nucleotide synthesis by dosage effect due to chromosome imbalances may be fundamental in carcinogenesis: the example of colorectal carcinoma. Ann Genet (Paris) 29: 11–15Google Scholar
  54. Ernst C, Thurin J, Atkinson B, Wurzel H, Herlyn M, Stromberg N, Cevin C, Koprowski H (1984) Monoclonal antibody localization of A and B isoantigens in normal and malignant fixed human tissues. Am J Pathol 117: 451–461PubMedGoogle Scholar
  55. Farber E (1984) Pre-cancerous steps in carcinogenesis. Biochim Biophys Acta 738:171–180 Fearon ER, Hamilton SR, Vogelstein B (1987) Clonal analysis of human colorectal tumors. Science 238: 193–197Google Scholar
  56. Feizi T (1985) Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are oncodevelopmental antigens. Nature 314: 53–57PubMedCrossRefGoogle Scholar
  57. Fett JW, Strydom DJ, Lobb RR, Alderman EM, Bethune JL, Riordan JF, Vallee BL (1985) Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells. Biochemistry 24: 5480–5486PubMedCrossRefGoogle Scholar
  58. Fex G, Ekelund G, Leandoer L, Sternby NH (1986) Cellular retinol-binding protein ( CRBP) in human colorectal adenocarcinoma. Br J Cancer 53: 687–690Google Scholar
  59. Filipe MI, Branfoot AC (1974) Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma. Cancer 34: 282–290PubMedCrossRefGoogle Scholar
  60. Finan PJ, Quirke P, Dixon MF, Dyson JED, Giles GR, Bird CC (1986) Is DNA aneuploidy a good prognostic indicator in patients with advanced colorectal cancer? Br J Cancer 54: 327–330PubMedCrossRefGoogle Scholar
  61. Forrester K, Almoguera C, Han K, Grizzle WE, Perucho M (1987) Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 327: 298–303PubMedCrossRefGoogle Scholar
  62. Fozard JBJ, Quirke P, Dixon MF, Giles GR, Bird CC (1986) DNA aneuploidy in ulcerative colitis. Gut 27: 1414–1418PubMedCrossRefGoogle Scholar
  63. Freeman HJ, Kim Y, Kim YS (1978) Glycoprotein metabolism in normal proximal and distal rat colon and changes associated with 1,2-dimethylhydrazine-induced colonic neoplasia. Cancer Res 38: 3385–3390PubMedGoogle Scholar
  64. Freeman HJ, Lotan R, Kim YS (1980) Application of lectins for detection of goblet cell glycoconjugate differences in proximal and distal colon of the rat. Lab Invest 42: 405–412PubMedGoogle Scholar
  65. Friedman E, Verderame M, Lipkin M, Pollack R (1985) Altered actin cytoskeletal patterns in two premalignant stages in human colon carcinoma development. Cancer Res 45: 3236–3242PubMedGoogle Scholar
  66. Friedman E, Verderame M, Winawer S, Pollack R (1984) Actin cytoskeletal organization loss in the benign-to-malignant tumor transition in cultured human colonic epithelial cells. Cancer Res 44: 3040–3050PubMedGoogle Scholar
  67. Fukushi Y, Hakomori S, Nudelman E, Cochran N (1984 a) Novel fucolipids accumulating in human adenocarcinoma. II. Selective isolation of hybridoma antibodies that differentially recognize mono-, di-, and trifucosylated type 2 chain. J Biol Chem 259: 4681–4685Google Scholar
  68. Fukushi Y, Nudelman E, Levery SB, Rauvala H, Hakomori S (1984 b) Novel fucolipids accumulating in human adenocarcinoma. III. A hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside (VI3NeuAcV3III3Fuc2nLc6). J Biol Chem 259: 10511–10 517Google Scholar
  69. Fukushima K, Hirota M, Terasaki PI, Wakisaka A, Togashi H, Chia D, Suyama N, Fukushi Y, Nudelman E, Hakomori S (1984) Characterization of sialosylated Lewis“ a new tumor associated antigen. Cancer Res 44: 5279–5285PubMedGoogle Scholar
  70. Geiger B, Kreis TE, Gigi O, Schmid E, Mittnacht S, Jorcano JL, von Bassewitz DB, Franke WW (1984) Dynamic rearrangements of cytokeratins in living cells. In: Levine AJ, Vande Wonde GF, Topp WC, Watson JD (eds) Cancer cells, the transformed phenotype. Cold Spring Harbor, New York, pp 201–215Google Scholar
  71. Gelister JSK, Mahmoud M, Gaffney PJ, Boulos PB (1986) Plasminogen activators in human colorectal neoplasia. Br Med J 293: 728–731CrossRefGoogle Scholar
  72. Gelister JSK, Jass JR, Mahmoud M, Gaffney PJ, Boulos PB (1987) Role of urokinase in colorectal neoplasia. Br J Surg 74: 460–463PubMedCrossRefGoogle Scholar
  73. Goh HS, Jass JR (1986) DNA content and the adenoma-carcinoma sequence in the colorectum. J Clin Pathol 39: 387–392PubMedCrossRefGoogle Scholar
  74. Gold DV, Miller F (1978) Comparison of human colonic mucoprotein antigen from normal and neoplastic mucosa. Cancer Res 38: 3204–3211PubMedGoogle Scholar
  75. Gold DV, Shochat D, Miller F (1981) Protease digestion of colonic mucin: evidence for the existence of two immunochemically distinct mucins. J Biol Chem 256: 6354–6358PubMedGoogle Scholar
  76. Gong E, Hirohashi S, Shimosato Y, Watanabe M, Ino Y, Teshima S, Kodaira S (1985) Expression of carbohydrate antigen 19–9 and stage specific embryonic antigen 1 in nontumorous and tumorous epithelia of the human colon and rectum. J Natl Cancer Inst 75:447–454 Google Scholar
  77. Gooi HC, Feizi T, Kapadia A, Knowles BB, Solter D, Evans MJ (1981) Stage specific embryonic antigen involves al ->3 fucosylated type 2 blood group chains. Nature 292: 156–158PubMedCrossRefGoogle Scholar
  78. Hakomori S (1981) Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. Annu Rev Biochem 50: 733–764PubMedCrossRefGoogle Scholar
  79. Hakomori S (1985) Aberrant glycosylation in cancer cell membranes as focused on glycolipids overview and perspectives. Cancer Res 45: 2405–2414PubMedGoogle Scholar
  80. Hakomori S, Fukuda M, Sekiguchi K, Carter WG (1984) Chemistry and function of pericellular and intercellular glycoproteins: fibronectin, laminin and other matrix components. In: Piez K, Reddi AH (eds) Extracellular matrix biochemistry. Elsevier/North-Holland Biomedical, Amsterdam, pp 229–275Google Scholar
  81. Hamilton SR, Luk GD (1987) Induction of colonic mucosal ornithine decarboxylase activity by chronic dietary ethanol consumption in rats. Gastroenterology 92: 1423Google Scholar
  82. Hand PH, Thor A, Schlom J, Rao CN, Liotta L (1985) Expression of laminin receptor in normal and carcinomatous human tissues as defined by a monoclonal antibody. Cancer Res 45: 2713–2719PubMedGoogle Scholar
  83. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove E (1983) Method for analysis of cellular DNA content in paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 31: 1333–1335PubMedCrossRefGoogle Scholar
  84. Herrera-Ornelas L, Porter C, Pera P, Greco W, Petrelli NJ, Mittelman A (1987) A comparison of ornithine decarboxylase and S-adenosylmethionine decarboxylase activity in human large bowel mucosa, polyps, and colorectal adenocarcinoma. J Surg Res 42: 56–60PubMedCrossRefGoogle Scholar
  85. Herzfeld A, Greengard 0 (1980) Enzyme activities in human fetal and neoplastic tissues. Cancer 46: 2047–2054Google Scholar
  86. Hoagland JG, Scoggin S, Giavazzi R, Campbell D, Kanellopoulos K, Jessup JM (1986) Tumor-derived suppressor factors ( TDSFs) in normal and neoplastic colon and rectum. J Surg Res 40: 467–474Google Scholar
  87. Holmes EH, Ostrander GK, Clausen H, Graem N (1987) Oncofetal expression of Le“ carbohydrate antigens in human colonic adenocarcinomas. Regulation through type 2 core chain synthesis rather than fucosylation. J Biol Chem 262:11 331–11 338Google Scholar
  88. Hoosein NM, Brattain DE, McKnight MK, Levine AE, Brattain MG (1987) Characterization of the inhibitory effects of transforming growth factor-ß on a human colon carcinoma cell line. Cancer Res 47: 2950–2954PubMedGoogle Scholar
  89. Hwang WI, Sack TL, Kim YS (1986) Effects of cyclic adenosine 3’,5’-monophosphate upon glycoprotein and carcinoembryonic antigen synthesis and release by human colon cancer cells. Cancer Res 46: 3371–3374PubMedGoogle Scholar
  90. Irimura T, Ota DM, Cleary KR (1987) Ulex europeus agglutinin-I-reactive high molecular weight glycoproteins of adenocarcinoma of distal colon and rectum and their possible relationship with metastatic potential. Cancer Res 47: 881–889Google Scholar
  91. Itzkowitz SH, Yuan M, Ferrell LD, Palekar A, Kim YS (1986 a) Cancer-associated alterations of blood group antigen expression in human colorectal polyps. Cancer Res 46: 5976–5984Google Scholar
  92. Itzkowitz SH, Yuan M, Fukushi Y, Palekar A, Phelps PC, Shamsuddin AM, Trump BF, Hakamori S, Kim YS (1986 b) Lewis“- and sialylated Lewis”-related antigen expression in human malignant and nonmalignant colonic tissues. Cancer Res 46: 2627–2632Google Scholar
  93. Izbicki JR, Schmitz R, Kamran D, Izbicki W (1983) Androgens as promoters of colon carcinogenesis. Cancer Detect Prey 6: 355–362Google Scholar
  94. Izbicki JR, Wambach G, Hamilton SR, Harnisch E, Hogenschurz R, Izbicki W, Kusche J (1986) Androgen receptors in experimentally induced colon carcinogenesis. J Cancer Res Clin Oncol 112: 39–46PubMedCrossRefGoogle Scholar
  95. Kaizu T, Levery SB, Nudelman E, Stenkamp RE, Hakomori S (1986) Novel fucolipids of human adenocarcinoma: monoclonal antibody specific for trifucosyl LeY (III3FucV3FucVI2FucnLc6) and a possible three-dimensional epitope structure. J Biol Chem 261:11 254–11 258Google Scholar
  96. Kanagalingam K, Balis ME (1975) In vivo repair of rat intestinal DNA damage by alkylating agents. Cancer 36: 2364–2372PubMedCrossRefGoogle Scholar
  97. Karlin DA, McBath M, Jones RD, Elwyn KE, Romsdahl MM (1985) Hypergastrinemia and colorectal carcinogenesis in the rat. Cancer Lett 29: 73–78PubMedCrossRefGoogle Scholar
  98. Kennedy MFG, Tutton PJM, Barkla DH (1985) Adrenergic factors regulating cell division in the colonic crypt epithelium during carcinogenesis and in colonic adenoma and adenocarcinoma. Br J Cancer 52: 383–390PubMedCrossRefGoogle Scholar
  99. Kijima-Suda I, Miyamoto Y, Toyoshima S, Itoh M, Osawa T (1986) Inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid: nucleoside conjugate having sialyltransferase inhibiting activity. Cancer Res 46: 858–862PubMedGoogle Scholar
  100. Kim YS, Isaacs R (1975) Glycoprotein metabolism in inflammatory and neoplastic diseases of the human colon. Cancer Res 35: 2092–2097PubMedGoogle Scholar
  101. Kim YS, Isaacs R, Perdomo JM (1974) Alterations of membrane glycopeptides in human colonic adenocarcinoma. Proc Natl Acad Sci USA 71: 4869–4873PubMedCrossRefGoogle Scholar
  102. Kim YS, Whitehead JS, Perdomo J (1979) Glycoproteins of cultured epithelial cells from human colonic adenocarcinoma and fetal intestine. Eur J Cancer 15: 725–735PubMedGoogle Scholar
  103. Kim YS, Yuan M, Itzkowitz SH, Sun Q, Kaizu T, Palekar A, Trump BF, Hakomori S (1986) Expression of Ley and extended Ley blood groups-related antigens in human malignant, premalignant and nonmalignant colonic tissues. Cancer Res 46: 5985–5992PubMedGoogle Scholar
  104. Kingsnorth AN, King WW, Diekema KA, McCann PP, Ross JS, Malt RA (1983 a) Inhibition of ornithine decarboxylase with 2-difluoromethylornithine: reduced incidence of dimethylhydrazine-induced colon tumors in mice. Cancer Res 43: 2545–2549Google Scholar
  105. Kingsnorth AN, Russell WE, McCann PP, Diekema KA, Malt RA (1983b) Effects of a-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line. Cancer Res 43: 4035–4038PubMedGoogle Scholar
  106. Kokal W, Sheibani K, Terz J, Horoda JR (1986) Tumor DNA content in the prognosis of colorectal carcinoma. JAMA 255: 3123–3127PubMedCrossRefGoogle Scholar
  107. Koprowski H, Steplewski Z, Mitchell K, Herlyn M, Herlyn D, Fuhrer P (1979) Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet 5: 957–971PubMedCrossRefGoogle Scholar
  108. Kornfeld R, Kornfeld S (1981) Structure of glycoproteins and their oligosaccharide units. In: Lennary WJ (ed) The biochemistry of glycoproteins and proteoglycans. Plenum, New York, pp 1–34Google Scholar
  109. Koss LG, Greenbaum E (1986) Measuring DNA in human cancer. JAMA 255:3158–3159 Kuhns WS, Schoentag R (1981) Carcinoma-related alterations of glycosyltransferascs in human tissue. Cancer Res 41: 2767–2772Google Scholar
  110. Kurosaka A, Nakajima H, Funakoshi 1, Matsuyama M, Nagayo T, Yamashina I (1983) Structure of the major oligosaccharides from a human rectal adenocarcinoma glycoprotein. J Biol Chem 258: 11594–11 598Google Scholar
  111. LaMont JT, Isselbacher KJ (1975) Alterations in glycosyltransferase activity in human colon cancer. J Natl Cancer Inst 54: 53–56PubMedGoogle Scholar
  112. LaMont JT, O’Gorman TA (1978) Experimental colon cancer. Gastroenterology 75:1157–1169 LaMont JT, Weiser MM, Isselbacher KJ (1974) Cell surface glycosyltransferase activity in normal and neoplastic intestinal epithelium of the rat. Cancer Res 34: 3225–3228Google Scholar
  113. LaMurglia GM, Lacaine R, Malt RA (1986) High ornithine decarboxylase activity and poly- amine levels in human colorectal neoplasia. Ann Surg 204: 89–93CrossRefGoogle Scholar
  114. Langvad E (1968) Lactate dehydrogenese isoenzyme patterns in the tumor bearing colon. Int J Cancer 3: 17–29PubMedCrossRefGoogle Scholar
  115. Lazarus P, Panasci LC (1987) Mechanism of decrease of protein synthesis by sodium cyanate in murine P388 leukemia cells. Cancer Res 47: 5102–5107PubMedGoogle Scholar
  116. Levin B, Reichmann A (1986) Chromosomes and large bowel tumors. Cancer Genet Cytogenet 19: 159–162PubMedCrossRefGoogle Scholar
  117. Levine AE, McRae U, Hamilton DA, Brattain DE, Yeoman LC, Brattain MG (1985) Identification of endogenous inhibitory growth factors from a human colon carcinoma cell line. Cancer Res 45: 2248–2254PubMedGoogle Scholar
  118. Liotta LA (1986) Tumor invasion and metastasis — role of the extracellular matrix: Rhoads memorial lecture. Cancer Res 46: 1–7PubMedCrossRefGoogle Scholar
  119. Liotta LA, Kleinerman J, Catanzara P, Gynbrandt D (1977) Degradation of basement membrane by murine tumor cells. J Natl Cancer Inst 58: 1427–1439PubMedGoogle Scholar
  120. Luk GD, Hamilton SR, Yang P, Smith JA, O’Ceallaigh D, McAvinchey D, Hyland J (1986) Kinetic changes in mucosal ornithine decarboxylase activity during azoxymethane-induced colonic carcinogenesis in the rat. Cancer Res 46: 4449–4452PubMedGoogle Scholar
  121. Luk GD, Silverman AL, Giardiello FM (1987) Biochemical markers in patients with familial colonic neoplasia. Semin Surg Oncol 3: 126–132PubMedCrossRefGoogle Scholar
  122. Magnani JL, Nilsson B, Brockhaus M, Zopf D, Steplewski Z, Koprowski H, Ginsburg V (1982) A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J Biol Chem 257: 14365–14369PubMedGoogle Scholar
  123. Magnani JL, Steplewski Z, Koprowski H, Ginsburg V (1983) Identification of the gastrointestinal and pancreatic associated antigen detected by monoclonal antibody 19–9 in the sera of patients as a mucin. Cancer Res 43: 5489–5492PubMedGoogle Scholar
  124. Marks ME, Danbury BH, Miller CA, Brattain MG (1983) Cell surface proteins and glycoproteins from biologically different human colon carcinoma cell lines. J Natl Cancer Inst 71: 663–771PubMedGoogle Scholar
  125. Matsushita Y, Yonezawa S, Nakamura T, Shimizu S, Ozawa M, Muramatsu T, Sato E (1985) Carcinoma-specific Ulex europaeus agglutinin-I binding glycoproteins of human colorectal carcinoma and its relation to carcinoembryonic antigen. J Natl Cancer Inst 75: 219–226PubMedGoogle Scholar
  126. Matthews J, Cooke T (1986) Changes in crypt cell DNA content during experimental colonic carcinogenesis. Br J Cancer 53: 787–791PubMedCrossRefGoogle Scholar
  127. McGinty F, Delides G, Harrison D (1973) The significance of enzyme histochemical patterns in carcinoma of the large intestine in man. Gut 14: 502–505PubMedCrossRefGoogle Scholar
  128. McKinley M, Budman D, Caccese W, Weissman G, Scheidt N, Kahn E, Bronzo R (1985)Google Scholar
  129. Evaluation of colonic neoplasia by flow cytometry of endoscopie biopsies. Am J Gastroenterol 80:47–49Google Scholar
  130. Melamed MR, Enker WE, Banner P, Janov AJ, Kessler G, Darzynkiewicz Z (1986) Flow cytometry of colorectal carcinoma with three-year follow-up. Dis Colon Rectum 29: 184–186PubMedCrossRefGoogle Scholar
  131. Mian N, Cowen DM (1974) Glycosidases in normal and dimethylhydrazine-treated rats and mice with special reference to the colonic tumors. Br J Cancer 29: 438–446PubMedCrossRefGoogle Scholar
  132. Mian N, Herries DG, Cowen DM, Batte EA (1979) The multiple forms and kinetic properties of the N-acetyl-ß-D-hexosaminidases from colonic tumors and mucosa of rats treated with 1,2-dimethylhydrazine. Biochem J 177: 319–330PubMedGoogle Scholar
  133. Moon RC, Fricks CM (1977) Influence of gonadal hormones and age on 1,2-dimethylhydrazine-induced colon carcinogenesis. Cancer 40: 2502–2508PubMedCrossRefGoogle Scholar
  134. Moorehead RJ, Hoper M, McKelvey ST (1987) Assessment of ornithine decarboxylase activity in rectal mucosa as a marker of colorectal adenomas and carcinomas. Br J Surg 74: 364–365PubMedCrossRefGoogle Scholar
  135. Mooseker MS (1985) Organization, chemistry and assembly of the cytoskeletal apparatus of the intestinal brush border. Annu Rev Cell Biol 1: 209–241PubMedCrossRefGoogle Scholar
  136. Morris DR, Marton LJ (eds) (1981) Polyamines in biology and medicine. Dekker, New YorkGoogle Scholar
  137. Moshier JA, Luk GD, Huang RCC (1986) mRNA from human colon tumor and mucosa related to the pol gene of an endogenous A-type retrovirus. Biochem Biophys Res Commun 139: 1071–1077Google Scholar
  138. Nachlas MN, Hannibal MJ (1961) Histochemical observations of the polyp-carcinoma sequence. Surg Gynecol Obstet 112: 534–542PubMedGoogle Scholar
  139. Narisawa T, Hosaka S, Niwa M (1985) Prostaglandin E2 counteracts the inhibition by indomethacin of rat colon ornithine decarboxylase induction by deoxycholic acid. Jpn J Cancer Res 76: 338–344PubMedGoogle Scholar
  140. Nelson RL, Wilson W, Samelson SL, Khoobyarian N (1987) The interaction of retrovirus and chemical carcinogen in experimental colon carcinogenesis. Surgery 101: 172–175PubMedGoogle Scholar
  141. Odagiri E, Jibiki K, Demura R, Shinozaki H, Nakamura S, Demura H, Suzuki H (1984) Steroid receptors and the distribution of IR-carcinoembryonic antigen in colon cancer. Dis Colon Rectum 27: 787–791PubMedCrossRefGoogle Scholar
  142. Odagiri E, Jibiki K, Kato Y, Nakamura S, Oda S-I, Demura R, Demura H (1985) Steroid receptors in dimethylhydrazine-induced colon carcinogenesis. Cancer 56: 2627–2634PubMedCrossRefGoogle Scholar
  143. O’Gorman TA, LaMont JT (1978) Glycoprotein synthesis and secretion in human colon cancers and normal colonic mucosa. Cancer Res 38: 2784–2789Google Scholar
  144. Olden K, Parnet JB, White SL (1982) Carbohydrate moieties of glycoproteins, a reevaluation of their function. Biochim Biophys Acta 650: 209–232PubMedCrossRefGoogle Scholar
  145. Ong DE, Markert C, Chiu J-F (1978) Cellular binding proteins for vitamin A in colorectal adenocarcinoma of rat. Cancer Res 38: 4422–4426PubMedGoogle Scholar
  146. Paraskeva C, Buckle BG, Sheer D, Wigley CB (1984) The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis soli patients. Int J Cancer 34: 49–56PubMedCrossRefGoogle Scholar
  147. Paris H, Bouscarel B, Cortinovis C, Murat JC (1985) Growth-related variation of a-adrenergic receptivity in the HT 29 adenocarcinoma cell-line from human colon. FEBS Lett 184: 82–86PubMedCrossRefGoogle Scholar
  148. Pegg AE, McCann PP (1982) Polyamine metabolism and function. Am J Physiol 243: C212 — C221PubMedGoogle Scholar
  149. Petersen SE (1985) Flow cytometry of human colorectal tumors: nuclear isolation by detergent technique. Cytometry 6: 452–460PubMedCrossRefGoogle Scholar
  150. Podolsky DK, Weiser MM, Westwood JC, Gammon M (1977) Cancer-associated serum galactosyltransferase activity. J Biol Chem 252: 1807–1813PubMedGoogle Scholar
  151. Quirke P, Fozard JBJ, Dixon MF, Dyson JED, Giles GR, Bird CC (1986) DNA aneuploidy in colorectal adenomas. Br J Cancer 53: 477–481PubMedCrossRefGoogle Scholar
  152. Quirke P, Dixon MF, Clayden AD, Durdey P, Dyson JED, Williams NS, Bird CC (1987) Prognostic significance of DNA aneuploidy and cell proliferation in rectal adenocarcinomas. J Pathol 151: 285–291PubMedCrossRefGoogle Scholar
  153. Reichmann A, Martin P, Levin B (1981) Chromosomal banding patterns in human large bowel cancer. Int J Cancer 28: 431–440PubMedCrossRefGoogle Scholar
  154. Reid PE, Culling CFA, Dunn WL, Ramey CW, Clay MG (1975) Differences in chemical composition between the epithelial glycoproteins of the upper and lower halves of rat colon. Can J Biochem 53: 1328–1332PubMedCrossRefGoogle Scholar
  155. Reid PE, Owen DA, Dunn WL, Ramey CW, Lazosky, Clay MG (1985) Chemical and histochemical studies of normal and diseased human gastrointestinal tract. III. Changes in the histochemical and chemical properties of the epithelial glycoproteins in the mucosa close to colonic tumors. Histochem J 17: 171–181Google Scholar
  156. Rousset M, Paris H, Chevalier G, Terrain B, Murat J-C, Zweibaum A (1984) Growth-related enzymatic control of glycogen metabolism in cultured human tumor cells. Cancer Res 44: 154–160PubMedGoogle Scholar
  157. Rozhin J, Wilson PS, Bull AW, Nigro ND (1984) Ornithine decarboxylase activity in the rat and human colon. Cancer Res 44: 3226–3230PubMedGoogle Scholar
  158. Russell DH (1983) Clinical relevance of polyamines. CRC Crit Rev Clin Lab Sci 18: 261–311CrossRefGoogle Scholar
  159. Rybak SM, Fett JW, Yao Q-Z, Vallee BL (1987) Angiogenin mRNA in human tumor and normal cells. Biochem Biophys Res Commun 146: 1240–1248PubMedCrossRefGoogle Scholar
  160. Sakamoto J, Furukawa K, Cordon-Cardo C, Yin BWT, Rettig WJ, Oettgen HF, Old LJ, Lloyd KO (1986) Expression of Lewis’, Lewis’, X and Y blood group antigens in human colonic tumors and normal tissue and in human tumor-derived cell lines. Cancer Res 46: 1553–1561Google Scholar
  161. Sakamoto S, Kuwa K, Tsukada K, Sagara T, Kasahara N, Okamoto R (1987) Relative activities of thymidylate synthetase and thymidine kinase in 1,2-dimethylhydrazine-induced colon carcinomas in rats. Carcinogenesis 8: 405–408PubMedCrossRefGoogle Scholar
  162. Sakamoto S, Sagara T, Iwama T, Kawasaki T, Okamoto R (1985) Increased activities of thymidine kinase isozymes in human colon polyp and carcinoma. Carcinogenesis 6: 917–919PubMedCrossRefGoogle Scholar
  163. Salo T, Liotta LA, Trggvason K (1983) Purification and characterization of a murine basement membrane collagen-degrading enzyme secreted by metastatic tumor cells. J Biol Chem 258: 3058–3063PubMedGoogle Scholar
  164. Sani BP, Banerjee CK (1983) Cellular receptor mediation of the action of retinoic acid. In: Meyskens FL, Prasad KN (eds) Modulation and mediation of cancer by vitamins. Karger, Basel, pp 153–161Google Scholar
  165. Sani BP, Banerjee CK, Peckham JC (1980) The presence of binding proteins for retinoic acid and dihydrotestosterone in murine and human colon tumors. Cancer 46: 2421–2429PubMedCrossRefGoogle Scholar
  166. Savage AP, Matthews JL, Ghatei MA, Cooke T, Bloom SR (1987) Enteroglucagon and experi- mental intestinal carcinogenesis in the rat. Gut 28: 33–39PubMedCrossRefGoogle Scholar
  167. Saydjari R, Townsend CM, Barranco SC, Thompson JC (1987) Effects of cyclosporine and a-difluoromethylornithine on the growth of mouse colon cancer in vitro. Life Sci 40: 359–366PubMedCrossRefGoogle Scholar
  168. Shamsuddin AKM, Trump BF (1981) Colon epithelium. I. Light microscopic, histochemical, and ultrastructural features of normal colon epithelium of male Fischer 344 rats. J Natl Cancer Inst 66: 375–388PubMedGoogle Scholar
  169. Shi ZR, McIntyre LJ, Knowles BB, Solter D, Kim YS (1984) Expression of a carbohydrate differentiation antigen stage specific embryonic antigen 1 in human colonic adenocarcinoma. Cancer Res 44: 1142–1147PubMedGoogle Scholar
  170. Shioda Y, Brown WR, Ahnen AJ (1987) Serial observations of colonic carcinogenis in the rat. Premalignant mucosa binds Ulex europeus agglutinin. Gastroenterology 92: 1–12PubMedGoogle Scholar
  171. Shonk CE, Arison RN, Koven BJ, Majima H, Boxer GE (1965) Enzyme patterns in human tissues. III. Glycolytic enzymes in normal and malignant tissues of the colon and rectum. Cancer Res 25: 206–213Google Scholar
  172. Siddiqui B, Whitehead JS, Kim YS (1978) Glycosphingolipids in human colonic adenocarcinoma. J Biol Chem 253: 2168–2175PubMedGoogle Scholar
  173. Singh P, Walker JP, Townsend CM, Thompson JC (1986) Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC-26) in BALB/c mice. Cancer Res 46: 1612–1616PubMedGoogle Scholar
  174. Solomon E, Voss R, Hall V, Bodmer WF, Jass JR, Jeffreys AJ, Lucibello FC, Patel I, Rider SH (1987) Chromosome 5 allele loss in human colorectal carcinomas. Nature 328: 616–619PubMedCrossRefGoogle Scholar
  175. Sporn MB, Roberts AB (1985) Autocrine growth factors and cancer. Nature 313: 745–747PubMedCrossRefGoogle Scholar
  176. Sporn MB, Dunlop NM, Newton DL, Smith JM (1976) Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc 35: 1332–1338Google Scholar
  177. Stebbings WSL, Farthing MJG, Vinson GP, Northover JMA, Wood RFM (1986) Androgen receptors in rectal and colonic cancer. Dis Colon Rectum 29: 95–98PubMedCrossRefGoogle Scholar
  178. Stevens RH, Loven DP (1980) Intracellular adenosine and guanosine 3’,5’-cyclic monophosphate concentrations in rat small and large bowel following a single and multiple exposure to 1,2-dimethylhydrazine. Cancer Lett 9: 151–159PubMedCrossRefGoogle Scholar
  179. Stuart CA, Prince MJ, Peters EJ, Smith FE, Townsend CM, Poffenbarger PL (1986) Insulin receptor proliferation: a mechanism for tumor-associated hypoglycemia. J Clin Endocrinol Metab 63: 879–885PubMedCrossRefGoogle Scholar
  180. Summerton J, Flynn M, Cooke T, Taylor I (1983) Bile acid receptors in colorectal cancer. Br J Surg 70: 549–551PubMedCrossRefGoogle Scholar
  181. Summerton J, Goeting N, Trotter GA, Taylor I (1985) Effect of deoxycholic acid on the tumour incidence, distribution, and receptor status of colorectal cancer in the rat model. Digestion 31: 77–81PubMedCrossRefGoogle Scholar
  182. Sun AS, Sepkowitz K, Geller SA (1981) A study of some mitochondrial and peroxisomal enzymes in human colonic adenocarcinoma. Lab Invest 44: 13–17PubMedGoogle Scholar
  183. Sun Q, Siddiqui B, Nudelman E, Hakomori S, Ho JJL, Kim YS (1987) New murine monoclonal antibodies to a human colonic cancer-associated glycolipid, extended difucosylated Ley glycolipid. Cancer J 1: 213–221Google Scholar
  184. Sunkara PS, Rao PN, Nishioka K, Brinkley BR (1979) Role of polyamines in cytokinesis of mammalian cells. Exp Cell Res 119: 63–68PubMedCrossRefGoogle Scholar
  185. Suzuki H, Umehara N (1986) Early mucosal changes in dimethylhdrazine-induced colonic carcinogenesis in rats. Jpn J Surg 16: 140–143PubMedCrossRefGoogle Scholar
  186. Suzuki H, Honda E, Matsumoto K, Iriyama K (1985) Tissue CEA determination and cytophotometric DNA analysis of colorectal mucosa in patients with colorectal cancer. Jpn J Surg 15: 449–454PubMedCrossRefGoogle Scholar
  187. Takano S, Matsushima M, Erturk E, Bryan GT (1981) Early induction of rat colonic epithelial ornithine and S-adenosyl-L-methionine decarboxylase activities by N-methyl-N’-nitro-Nnitrosoguanidine or bile salts. Cancer Res 41: 624–628PubMedGoogle Scholar
  188. Talpaz M, Plager C, Quesada J, Benjamin R, Kantarjian H, Gutterman J (1986) Difluoromethylornithine and leukocyte interferon: a phase I study in cancer patients. Eur J Cancer Clin Oncol 22: 685–689PubMedCrossRefGoogle Scholar
  189. Tempero M (1986) Bile acids, ornithine decarboxylase, and cell proliferation in colon cancer: a review. Dig Dis 4: 49–56PubMedCrossRefGoogle Scholar
  190. Ten Kate J, Van Den Ingh HFGM, Khan PM, Bosman FT (1986) Adenosine deaminase complexing protein ( ADCP) immunoreactivity in colorectal adenocarcinoma. Int J Cancer 37: 479–485Google Scholar
  191. Tricoli JV, Rall LB, Karakousis CP, Herrera L, Petrelli NJ, Bell GI, Shows TB (1986) Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas. Cancer Res 46: 6169–6173PubMedGoogle Scholar
  192. Trotta PP, Balis ME (1977) Enzyme variants in normal and neoplastic intestinal mucosa. Cancer 40: 2592–2599PubMedCrossRefGoogle Scholar
  193. Tsao D, Freeman HJ, Kim YS (1979) ß-Hexosaminidase isoenzymes in tissues, cultured cells, and media from human fetal intestine and colonic adenocarcinoma. Cancer Res 39: 3405–3410PubMedGoogle Scholar
  194. Tutton PJM, Barkla DH (1982) The influence of androgens, antiandrogens, and castration on cell proliferation in the jejunal and colonic crypt epithelia, and in dimethylhydrazine-induced adenocarcinoma of rat colon. Virchows Arch [B] 38: 351–355CrossRefGoogle Scholar
  195. Tutton PJM, Barkla DH (1986) Comparison of the effects of an ornithine decarboxylase inhibitor on the intestinal epithelium and on intestinal tumors. Cancer Res 46:6091–6094 Warburg 0 (1956) On the origin of cancer cells. Science 123: 309–314Google Scholar
  196. Wattenberg LW (1959) A histochemical study of five oxidative enzymes in carcinoma of the large intestine in man. Am J Pathol 35: 113–137PubMedGoogle Scholar
  197. Weber G (1977) Enzymology of cancer cells. N Engl J Med 296: 486–493PubMedCrossRefGoogle Scholar
  198. Weber G, Kizaki H, Tzeng D, Shiotani T, Olah E (1978) Colon tumor: enzymology of the neoplastic program. Life Sci 23: 729–736PubMedCrossRefGoogle Scholar
  199. Weber G, Lui MS, Takeda E, Denton JE (1980) Enzymology of human colon tumors. Life Sci 27: 793 — 799Google Scholar
  200. Weiner HL, Weiner LH, Swain JL (1987) Tissue distribution and developmental expression of the messenger RNA encoding angiogenin. Science 237: 280–282PubMedCrossRefGoogle Scholar
  201. Weiser MM, Podolsky DK, Isselbacher KJ (1976) Cancer-associated isoenzyme of serum galactosyltransferase. Proc Natl Acad Sci USA 73: 1319–1327PubMedCrossRefGoogle Scholar
  202. Whitehead JS, Fearney FJ, Kim YS (1979) Glycosyltransferase and glycosidase activities in cultured human fetal and colonic adenocarcinoma cell lines. Cancer Res 39: 1259–1263PubMedGoogle Scholar
  203. Wice BM, Trugnan G, Pinto M, Rousset M, Chevalier G, Dussaulx E, Lacroix B, Zweibaum A (1985) The intracellular accumulation of UDP-N-adenylhexosamine is concomitant with the mobility of human colon cancer cells to differentiate. J Biol Chem 260: 139–146PubMedGoogle Scholar
  204. Wiley EL, Mendelsohn G, Eggleston JC (1981) Distribution of carcinoembryonic antigens and blood group substances in adenocarcinoma of the colon. Lab Invest 44: 507–513PubMedGoogle Scholar
  205. Winsett 0E, Townsend CM, Glass EJ, Rae-Venter B, Thompson JC (1986) Gastrin stimulates growth of colon cancer. Surgery 99: 302–307Google Scholar
  206. Wobbes T, Beex LV, Koenders AM (1984) Estrogen and progestin receptors in colonic cancer? Dis Colon Rectum 27: 591–592PubMedCrossRefGoogle Scholar
  207. Yamakawa T, Nagai Y (1978) Glycolipids at the cell surface and their biological significance. Trends Biochem Sci 3: 128–131CrossRefGoogle Scholar
  208. Yeger H, Baumal R, Kahn HJ, Duwe G, Phillips MJ (1986) The use of cytoskeletal characteristics of tumor cells for the diagnosis of colon and breast adenocarcinomas. Am J Clin Pathol 86: 697–705PubMedGoogle Scholar
  209. Yonezawa S, Nakamura T, Tanaka S, Sato E (1982) Glycoconjugate with Ulex europaeus agglutinin-1-binding sites in normal mucosa, adenoma, and carcinoma of the human large bowel. J Natl Cancer Inst 69: 777–785PubMedGoogle Scholar
  210. Yonezawa S, Nakamura T, Tanaka S, Moruta K, Nishi M, Sato E (1983) Binding of Ulex europeaus agglutinin 1 in polyposis coli: comparative study with solitary adenocarcinoma in the sigmoid colon and rectum. J Natl Cancer Inst 71: 19–24PubMedGoogle Scholar
  211. Youakim A, Herscovics A (1985) Cell surface glycopeptides from human intestinal epithelial cell lines derived from normal colon and colon adenocarcinomas. Cancer Res 45: 5505–5511PubMedGoogle Scholar
  212. Yuan M, Itzkowitz SH, Boland CR, Kim YD, Tomita JT, Polekas A, Bennington JL, Trump BJ, Kim YS (1986) Comparison of T-antigen expression in normal, premalignant, and malignant human colonic tissue using lectin and antibody immunohistochemistry. Cancer Res 46: 4841–4847PubMedGoogle Scholar
  213. Yuan M, Itzkowitz SH, Ferrell LD, Fukushi Y, Palekar A, Hakomori S, Kim YS (1987) Expression of Lewis’ and sialylated Lewis“ antigens in human colorectal polyps. J Natl Cancer Inst 78: 479–488PubMedGoogle Scholar
  214. Yuan M, Itzkowitz SH, Palekar A, Shamsuddin AM, Phelps PC, Trump BF, Kim YS (1985) Distribution of blood group antigens A, B, H, Lewis’, and Lewisb in human normal, fetal, and malignant colonic tissue. Cancer Res 45: 4499–4511PubMedGoogle Scholar
  215. Zweibaum A, Pinto M, Chevalier G, Dussaulx E, Triadau N, Lacroix B, Haffen K, Brun J-L, Roussel M (1985) Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT-29 selected for growth in sugar-free medium and its inhibition by glucose. J Cell Physiol 122: 21–29PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • N. W. Toribara
    • 1
  • S. B. Ho
    • 1
  • R. S. Bresalier
    • 1
  • Y. S. Kim
    • 1
  1. 1.Gastrointestinal Research LaboratoryVeterans Administration Medical CenterSan FranciscoUSA

Personalised recommendations