Skip to main content

Biochemical Changes in Colorectal Carcinogenesis

  • Chapter
Colorectal Cancer
  • 134 Accesses

Abstract

Technological advances over the past decade have produced a remarkable expansion in our knowledge of the basic biological processes involved in cell growth and replication. Nevertheless, our understanding of these processes both under normal and pathological circumstances is far from complete and, in fact, can be considered to be early in its evolution.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abe K, McKibbin JM, Hakomori S (1983) The monoclonal antibody directed to difucosylated type 2 chain (Fucαl → 2 Galß1 →4 [Fucαl → 3] G1cNAc; Y determinant). J Biol Chem 258:11 793–11 797

    Google Scholar 

  • Abe K, Hakomori S, Ohshiba S (1986) Differential expression of difucosyl type 2 chain (Ley) defined by monoclonal antibody AH6 in different locations of colonic epithelia, various histological types of colonic polyps, and adenocarcinomas. Cancer Res 46: 2639–2644

    PubMed  CAS  Google Scholar 

  • Abeloff MD, Rosen ST, Luk GD, Baylin SB, Zeltzman M, Sjoerdsma A (1986) Phase II trials of a-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer. Cancer Treat Rep 70: 843–845

    PubMed  CAS  Google Scholar 

  • Allfrey VG, Boffa LC, Vidali G (1977) Selective inhibition with sodium cyanate of protein synthesis in colon cancer cells. Cancer 40: 2692–2698

    Article  PubMed  CAS  Google Scholar 

  • Arends JW, Verstynen C, Bosman FT, Hilgers J, Steplewski Z (1983) Distribution of monoclonal antibody-defined monosialoganglioside in normal and cancerous human tissues: an immunoperoxidase study. Hybridoma 2: 219–229

    Article  PubMed  CAS  Google Scholar 

  • Armitage NC, Robins RA, Evans DF, Turner DR, Baldwin RW, Hardcastle JD (1985) The influence of tumour cell DNA abnormalities on survival in colorectal cancer. Br J Surg 72: 828–830

    Article  PubMed  CAS  Google Scholar 

  • Atkinson BF, Ernst CS, Herlyn M, Steplewski Z, Sears HF, Koprowski H (1982) Gastrointestinal cancer-associated antigen in immunoperoxidase assay. Cancer Res 42: 4820–4823

    PubMed  CAS  Google Scholar 

  • Balis ME, Higgins PJ, Salser JS (1981) Enzymes of normal, premalignant, and malignant colonic cells. In: Bruce WR, Correa P, Lipkin M, Tannenbaum SR, Wilkins TD (eds) Banbury report no 7: Gastrointestinal cancer: endogenous factors. Cold Spring Harbor, New York, pp 129–139

    Google Scholar 

  • Bara J, Nardelli J, Gadenne C, Prade M, Bertin P (1984) Differences in the expression of mucus-associated antigens between proximal and distal human colon adenocarcinomas. Br J Cancer 49: 495–501

    Article  PubMed  CAS  Google Scholar 

  • Bara J, Gautier R, Daher N, Zaghouani H, Decaens C (1986) Monoclonal antibodies against oncofetal mucin M1 antigens associated with precancerous colonic mucosae. Cancer Res 46: 3983–3989

    PubMed  CAS  Google Scholar 

  • Basu A, Murthy U, Rodeck U, Herlyn M, Mattes L, Das M (1987) Presence of tumor-associated antigens in epidermal growth factor receptors from different human carcinomas. Cancer Res 47: 2531–2536

    PubMed  CAS  Google Scholar 

  • Bauer KD, Clevenger CV, Endow RK, Murad T, Epstein AL, Scarpelli DG (1986) Simultaneous nuclear antigen and DNA content quantitation using paraffin-embedded colonic tissue and multiparameter flow cytometry. Cancer Res 46: 2428–2434

    PubMed  CAS  Google Scholar 

  • Becher R, Gibas Z, Sandberg AA (1983) Involvement of chromosomes 7 and 12 in large bowel cancer: trisomy 7 and 12q-. Cancer Genet Cytogenet 8: 329–332

    Article  Google Scholar 

  • Bertram JS, Mordan LJ, Domanska-Janik K, Bernacki RJ (1982) Inhibition of in vitro neoplastic transformation by retinoids. In: Arnott MS, Van Eys J, Wang YM (eds) Molecular interrelations of nutrition and cancer. Raven, New York, pp 315–335

    Google Scholar 

  • Bloom EJ, Itzkowitz SH, Kim YS (in press) Carbohydrate tumor markers in colon cancer and polyps. In: Moyer MP, Posk GH (eds) Colon cancer cells. Academic, New York

    Google Scholar 

  • Bodmer WF, Bailey CJ, Bodmer J, Bussey HJR, Ellis A, Gorman P, Lucibello FC, Murday VA, Rider SH, Scambler P, Sheer D, Solomon E, Spurr NK (1987) Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 328: 614–616

    Article  PubMed  CAS  Google Scholar 

  • Boffa LC, Allfrey VG (1977) Changes in chromosomal proteins in colon cancer. Cancer 40: 2584–2591

    Article  PubMed  CAS  Google Scholar 

  • Boffa LC, Diwan BA, Gruss R, Allfrey VG (1980) Differences in colonic nuclear proteins of two mouse strains with different susceptibilities to 1,2-dimethylhydrazine-induced carcinogenesis. Cancer Res 40: 1774–1780

    PubMed  CAS  Google Scholar 

  • Boffa LC, Kozak S, Allfrey VG (1981) Activation of sodium cyanate for selective inhibition of protein synthesis in cultured tumor cells. Cancer Res 41: 60–66

    PubMed  CAS  Google Scholar 

  • Boland CR, Ahnen DJ (1985) The binding of lesions to goblet cell mucin in premalignant colonic epithelium of the CF-1 mouse. Gastroenterology 89: 127–137

    PubMed  CAS  Google Scholar 

  • Boland CR, Clapp NK (1987) Glycoconjugates in the colon of new world monkeys with spontaneous colitis. Gastroenterology 92: 625–634

    PubMed  CAS  Google Scholar 

  • Boland CR, Montgomery CK, Kim YS (1982 a) Alterations in human colonic mucin occurring with cellular differentiation and malignant transformation. Proc Natl Acad Sci USA 79: 2051–2055

    Google Scholar 

  • Boland CR, Montgomery CK, Kim YS (1982 b) A cancer-associated mucin alteration in benign colonic polyps. Gastroenterology 82: 664–672

    Google Scholar 

  • Bos JL, Fearon ER, Hamilton SR, Verlaan-de Vries M, van Boom JH, van der Eb AJ, Vogelstein B (1987) Prevalence of ras gene mutations in human colorectal cancers. Nature 327: 293–297

    Article  PubMed  CAS  Google Scholar 

  • Bradley SJ, Garfinkle G, Walker E, Salem R, Chen LB, Steele G (1986) Increased expression of the epidermal growth factor receptor on human colon carcinoma cells. Arch Surg 121: 1242–1247

    Article  PubMed  CAS  Google Scholar 

  • Brasitus TA, Dudeja PK, Dahiya R (1986) Premalignant alteration in the lipid composition and fluidity of colonic brush border membranes of rats administered 1,2-dimethylhydrazine. J Clin Invest 77: 831–840

    Article  PubMed  CAS  Google Scholar 

  • Brattain MG, Kimball PM, Pretlow TG (1977) ß-hexosaminidase isoenzymes in human colonic carcinoma. Cancer Res 37: 731–735

    PubMed  CAS  Google Scholar 

  • Brattain MG, Green C, Kimball PM, Marks M, Khaled M (1979) Isoenzymes of ß-hexosaminidase from normal rat colon and colonic carcinoma. Cancer Res 39: 4083–4090

    PubMed  CAS  Google Scholar 

  • Brattain MG, Levine AE, Chakrabarty S, Yeoman LC, Willson JK, Long B (1984) Heterogeneity of human colon carcinoma. Cancer Metastasis Rev 3: 177–191

    Article  PubMed  CAS  Google Scholar 

  • Bresalier RS, Boland CR, Kim YS (1984) Characteristics of colorectal carcinoma cells with high metastatic potential. Gastroenterology 87: 115–122

    PubMed  CAS  Google Scholar 

  • Bresalier RS, Boland CR, Kim YS (1985) Regional differences in normal and cancer-associated glycoconjugates of the human colon. J Natl Cancer Inst 75: 249–260

    PubMed  CAS  Google Scholar 

  • Bresalier RS, Hujanen ES, Raper SE, Roll FJ, Itzkowitz SH, Martin GR, Kim YS (1987 a) An animal model for colon cancer metastasis: establishment and characterization of murine cell lines with enhanced liver-metastasizing ability. Cancer Res 47: 1398–1406

    Google Scholar 

  • Bresalier RS, Raper SE, Hujanen ES, Kim YS (1987 b) A new animal model for human colon cancer metastasis. Int J Cancer 39: 625–630

    Google Scholar 

  • Bristol JB, Ghatei MA, Smith JHF, Bloom SR, Williamson RCN (1987) Elevated plasma enteroglucagon alone fails to alter distal colonic carcinogenesis in rats. Gastroenterology 92: 617–624

    PubMed  CAS  Google Scholar 

  • Burtin P, Chavanel G, Andre J (1985) The plasmin system in human colonic tumors: an immunofluorescence study. Int J Cancer 35: 307–314

    Article  PubMed  CAS  Google Scholar 

  • Burtin P, Chavanel G, Andre-Bougaran J, Gentile A (1987) The plasmin system in human adenocarcinomas and their metastases. A comparative immunofluorescence study. Int J Cancer 39: 170–178

    Google Scholar 

  • Cajot J-F, Sordat B, Kruithof E, Bachman F ( 1986 a) Human primary colon carcinomas xenografted into nude mice. I. Characterization of plasminogen activators expressed by primary tumors and their xenografts. J Natl Cancer Inst 77: 703–712

    Google Scholar 

  • Cajot J-F, Sordat B, Bachman F ( 1986 b) Human primary colon carcinomas xenografted into nude mice. II. Modulation of tumor plasminogen activator activity by the host tissue environment. J Natl Cancer Inst 77: 1099–1107

    Google Scholar 

  • Chakrabarty S, Jan Y, Miller CA, Brattain MG (1985) Selective nuclear protein phospho- rylation/dephosphorylation in subpopulations of human colonic carcinoma cells. Cancer Lett 28: 291–297

    Article  PubMed  CAS  Google Scholar 

  • Chen LB, Rosenberg S, Nadakavukaren KK, Walker ES, Shepherd EL, Steele GD (1985) The cytoskeleton. In: Springer TA (ed) Hybridoma technology and the biosciences and medicine. Plenum, New York, pp 251–268

    Chapter  Google Scholar 

  • Chesa PG, Rettig WJ, Melamed MR (1986) Expression of cytokeratins in normal and neoplastic colonic epithelial cells. Implications for cellular differentiation and carcinogenic. Am J Surg Pathol 10: 829–835

    Google Scholar 

  • Coffey RJ, Shipley GD, Moses HL (1986) Production of transforming growth factors by human colon cancer lines. Cancer Res 46: 1164–1169

    PubMed  CAS  Google Scholar 

  • Cooper D, Schermer A, Sun T-T (1985) Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations. Lab Invest 52: 243–256

    PubMed  CAS  Google Scholar 

  • Cordon-Cardo C, Lloyd KO, Sakamoto J, McGroarty ME, Old LJ, Melamed MR (1986) Immunohistologic expression of blood group antigens in normal human gastrointestinal tract and colonic carcinoma. Int J Cancer 37: 667–676

    Article  PubMed  CAS  Google Scholar 

  • Czernobilsky B, Tsou KC (1968) Adenocarcinoma, adenomas and polyps of the colon. Cancer 21: 165–177

    Article  PubMed  CAS  Google Scholar 

  • Dahiya R, Dudeja PK, Brasitus TA (1987) Premalignant alterations in the glycosphingolipid composition of colonic epithelial cells of rats treated with 1,2-dimethylhydrazine. Cancer Res 47: 1031–1035

    PubMed  CAS  Google Scholar 

  • Denk H, Holzner JH, Obiditsch-Mayr I (1975) Epithelial blood group antigens in colon polyps. I. Morphologic distribution and relationship to differentiation. J Natl Cancer Inst 54: 1313–1317

    Google Scholar 

  • Denk H, Tappeiner G, Holzner JH (1974) Blood group substances as carcinofetal antigens in carcinomas of the distal colon. Eur J Cancer 10: 487–490

    PubMed  CAS  Google Scholar 

  • DeRubertis FR, Chayoth R, Field JB (1976) The content and metabolism of cyclic adenosine 3’,5’-monophosphate and cyclic guanosine 3’,5’-monophosphate in adenocarcinoma of the human colon. J Clin Invest 57: 641–649

    Article  PubMed  CAS  Google Scholar 

  • DeRubertis FR, Craven PA (1980) Early alterations in rat colonic mucosal cyclic nucleotide metabolism and protein kinase activity induced by 1,2-dimethylhydrazine. Cancer Res 40: 4589–4598

    PubMed  CAS  Google Scholar 

  • DiFronzo G, Cappelletti V, Miodini P, Bertario L, Ravasi G (1987) Role of cellular retinoic acid binding protein (cRABP) in patients with large bowel cancer. Cancer Detect Prey 10: 327–333

    CAS  Google Scholar 

  • d’Istria M, Fasano S, Catuogno F, Gaeta F, Bucci L, Benassal G, Mazzeo F, Delrio G (1986) Androgen and progesterone receptors in colonic and rectal cancers. Dis Colon Rectum 29: 263–265

    Article  PubMed  Google Scholar 

  • Dutrillaux B, Muleris M (1986) Induction of increased salvage pathways of nucleotide synthesis by dosage effect due to chromosome imbalances may be fundamental in carcinogenesis: the example of colorectal carcinoma. Ann Genet (Paris) 29: 11–15

    CAS  Google Scholar 

  • Ernst C, Thurin J, Atkinson B, Wurzel H, Herlyn M, Stromberg N, Cevin C, Koprowski H (1984) Monoclonal antibody localization of A and B isoantigens in normal and malignant fixed human tissues. Am J Pathol 117: 451–461

    PubMed  CAS  Google Scholar 

  • Farber E (1984) Pre-cancerous steps in carcinogenesis. Biochim Biophys Acta 738:171–180 Fearon ER, Hamilton SR, Vogelstein B (1987) Clonal analysis of human colorectal tumors. Science 238: 193–197

    Google Scholar 

  • Feizi T (1985) Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are oncodevelopmental antigens. Nature 314: 53–57

    Article  PubMed  CAS  Google Scholar 

  • Fett JW, Strydom DJ, Lobb RR, Alderman EM, Bethune JL, Riordan JF, Vallee BL (1985) Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells. Biochemistry 24: 5480–5486

    Article  PubMed  CAS  Google Scholar 

  • Fex G, Ekelund G, Leandoer L, Sternby NH (1986) Cellular retinol-binding protein ( CRBP) in human colorectal adenocarcinoma. Br J Cancer 53: 687–690

    Google Scholar 

  • Filipe MI, Branfoot AC (1974) Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma. Cancer 34: 282–290

    Article  PubMed  CAS  Google Scholar 

  • Finan PJ, Quirke P, Dixon MF, Dyson JED, Giles GR, Bird CC (1986) Is DNA aneuploidy a good prognostic indicator in patients with advanced colorectal cancer? Br J Cancer 54: 327–330

    Article  PubMed  CAS  Google Scholar 

  • Forrester K, Almoguera C, Han K, Grizzle WE, Perucho M (1987) Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 327: 298–303

    Article  PubMed  CAS  Google Scholar 

  • Fozard JBJ, Quirke P, Dixon MF, Giles GR, Bird CC (1986) DNA aneuploidy in ulcerative colitis. Gut 27: 1414–1418

    Article  PubMed  CAS  Google Scholar 

  • Freeman HJ, Kim Y, Kim YS (1978) Glycoprotein metabolism in normal proximal and distal rat colon and changes associated with 1,2-dimethylhydrazine-induced colonic neoplasia. Cancer Res 38: 3385–3390

    PubMed  CAS  Google Scholar 

  • Freeman HJ, Lotan R, Kim YS (1980) Application of lectins for detection of goblet cell glycoconjugate differences in proximal and distal colon of the rat. Lab Invest 42: 405–412

    PubMed  CAS  Google Scholar 

  • Friedman E, Verderame M, Lipkin M, Pollack R (1985) Altered actin cytoskeletal patterns in two premalignant stages in human colon carcinoma development. Cancer Res 45: 3236–3242

    PubMed  CAS  Google Scholar 

  • Friedman E, Verderame M, Winawer S, Pollack R (1984) Actin cytoskeletal organization loss in the benign-to-malignant tumor transition in cultured human colonic epithelial cells. Cancer Res 44: 3040–3050

    PubMed  CAS  Google Scholar 

  • Fukushi Y, Hakomori S, Nudelman E, Cochran N (1984 a) Novel fucolipids accumulating in human adenocarcinoma. II. Selective isolation of hybridoma antibodies that differentially recognize mono-, di-, and trifucosylated type 2 chain. J Biol Chem 259: 4681–4685

    Google Scholar 

  • Fukushi Y, Nudelman E, Levery SB, Rauvala H, Hakomori S (1984 b) Novel fucolipids accumulating in human adenocarcinoma. III. A hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside (VI3NeuAcV3III3Fuc2nLc6). J Biol Chem 259: 10511–10 517

    Google Scholar 

  • Fukushima K, Hirota M, Terasaki PI, Wakisaka A, Togashi H, Chia D, Suyama N, Fukushi Y, Nudelman E, Hakomori S (1984) Characterization of sialosylated Lewis“ a new tumor associated antigen. Cancer Res 44: 5279–5285

    PubMed  CAS  Google Scholar 

  • Geiger B, Kreis TE, Gigi O, Schmid E, Mittnacht S, Jorcano JL, von Bassewitz DB, Franke WW (1984) Dynamic rearrangements of cytokeratins in living cells. In: Levine AJ, Vande Wonde GF, Topp WC, Watson JD (eds) Cancer cells, the transformed phenotype. Cold Spring Harbor, New York, pp 201–215

    Google Scholar 

  • Gelister JSK, Mahmoud M, Gaffney PJ, Boulos PB (1986) Plasminogen activators in human colorectal neoplasia. Br Med J 293: 728–731

    Article  CAS  Google Scholar 

  • Gelister JSK, Jass JR, Mahmoud M, Gaffney PJ, Boulos PB (1987) Role of urokinase in colorectal neoplasia. Br J Surg 74: 460–463

    Article  PubMed  CAS  Google Scholar 

  • Goh HS, Jass JR (1986) DNA content and the adenoma-carcinoma sequence in the colorectum. J Clin Pathol 39: 387–392

    Article  PubMed  CAS  Google Scholar 

  • Gold DV, Miller F (1978) Comparison of human colonic mucoprotein antigen from normal and neoplastic mucosa. Cancer Res 38: 3204–3211

    PubMed  CAS  Google Scholar 

  • Gold DV, Shochat D, Miller F (1981) Protease digestion of colonic mucin: evidence for the existence of two immunochemically distinct mucins. J Biol Chem 256: 6354–6358

    PubMed  CAS  Google Scholar 

  • Gong E, Hirohashi S, Shimosato Y, Watanabe M, Ino Y, Teshima S, Kodaira S (1985) Expression of carbohydrate antigen 19–9 and stage specific embryonic antigen 1 in nontumorous and tumorous epithelia of the human colon and rectum. J Natl Cancer Inst 75:447–454

    Google Scholar 

  • Gooi HC, Feizi T, Kapadia A, Knowles BB, Solter D, Evans MJ (1981) Stage specific embryonic antigen involves al ->3 fucosylated type 2 blood group chains. Nature 292: 156–158

    Article  PubMed  CAS  Google Scholar 

  • Hakomori S (1981) Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. Annu Rev Biochem 50: 733–764

    Article  PubMed  CAS  Google Scholar 

  • Hakomori S (1985) Aberrant glycosylation in cancer cell membranes as focused on glycolipids overview and perspectives. Cancer Res 45: 2405–2414

    PubMed  CAS  Google Scholar 

  • Hakomori S, Fukuda M, Sekiguchi K, Carter WG (1984) Chemistry and function of pericellular and intercellular glycoproteins: fibronectin, laminin and other matrix components. In: Piez K, Reddi AH (eds) Extracellular matrix biochemistry. Elsevier/North-Holland Biomedical, Amsterdam, pp 229–275

    Google Scholar 

  • Hamilton SR, Luk GD (1987) Induction of colonic mucosal ornithine decarboxylase activity by chronic dietary ethanol consumption in rats. Gastroenterology 92: 1423

    Google Scholar 

  • Hand PH, Thor A, Schlom J, Rao CN, Liotta L (1985) Expression of laminin receptor in normal and carcinomatous human tissues as defined by a monoclonal antibody. Cancer Res 45: 2713–2719

    PubMed  CAS  Google Scholar 

  • Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove E (1983) Method for analysis of cellular DNA content in paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 31: 1333–1335

    Article  PubMed  CAS  Google Scholar 

  • Herrera-Ornelas L, Porter C, Pera P, Greco W, Petrelli NJ, Mittelman A (1987) A comparison of ornithine decarboxylase and S-adenosylmethionine decarboxylase activity in human large bowel mucosa, polyps, and colorectal adenocarcinoma. J Surg Res 42: 56–60

    Article  PubMed  CAS  Google Scholar 

  • Herzfeld A, Greengard 0 (1980) Enzyme activities in human fetal and neoplastic tissues. Cancer 46: 2047–2054

    CAS  Google Scholar 

  • Hoagland JG, Scoggin S, Giavazzi R, Campbell D, Kanellopoulos K, Jessup JM (1986) Tumor-derived suppressor factors ( TDSFs) in normal and neoplastic colon and rectum. J Surg Res 40: 467–474

    Google Scholar 

  • Holmes EH, Ostrander GK, Clausen H, Graem N (1987) Oncofetal expression of Le“ carbohydrate antigens in human colonic adenocarcinomas. Regulation through type 2 core chain synthesis rather than fucosylation. J Biol Chem 262:11 331–11 338

    Google Scholar 

  • Hoosein NM, Brattain DE, McKnight MK, Levine AE, Brattain MG (1987) Characterization of the inhibitory effects of transforming growth factor-ß on a human colon carcinoma cell line. Cancer Res 47: 2950–2954

    PubMed  CAS  Google Scholar 

  • Hwang WI, Sack TL, Kim YS (1986) Effects of cyclic adenosine 3’,5’-monophosphate upon glycoprotein and carcinoembryonic antigen synthesis and release by human colon cancer cells. Cancer Res 46: 3371–3374

    PubMed  CAS  Google Scholar 

  • Irimura T, Ota DM, Cleary KR (1987) Ulex europeus agglutinin-I-reactive high molecular weight glycoproteins of adenocarcinoma of distal colon and rectum and their possible relationship with metastatic potential. Cancer Res 47: 881–889

    Google Scholar 

  • Itzkowitz SH, Yuan M, Ferrell LD, Palekar A, Kim YS (1986 a) Cancer-associated alterations of blood group antigen expression in human colorectal polyps. Cancer Res 46: 5976–5984

    Google Scholar 

  • Itzkowitz SH, Yuan M, Fukushi Y, Palekar A, Phelps PC, Shamsuddin AM, Trump BF, Hakamori S, Kim YS (1986 b) Lewis“- and sialylated Lewis”-related antigen expression in human malignant and nonmalignant colonic tissues. Cancer Res 46: 2627–2632

    Google Scholar 

  • Izbicki JR, Schmitz R, Kamran D, Izbicki W (1983) Androgens as promoters of colon carcinogenesis. Cancer Detect Prey 6: 355–362

    CAS  Google Scholar 

  • Izbicki JR, Wambach G, Hamilton SR, Harnisch E, Hogenschurz R, Izbicki W, Kusche J (1986) Androgen receptors in experimentally induced colon carcinogenesis. J Cancer Res Clin Oncol 112: 39–46

    Article  PubMed  CAS  Google Scholar 

  • Kaizu T, Levery SB, Nudelman E, Stenkamp RE, Hakomori S (1986) Novel fucolipids of human adenocarcinoma: monoclonal antibody specific for trifucosyl LeY (III3FucV3FucVI2FucnLc6) and a possible three-dimensional epitope structure. J Biol Chem 261:11 254–11 258

    Google Scholar 

  • Kanagalingam K, Balis ME (1975) In vivo repair of rat intestinal DNA damage by alkylating agents. Cancer 36: 2364–2372

    Article  PubMed  CAS  Google Scholar 

  • Karlin DA, McBath M, Jones RD, Elwyn KE, Romsdahl MM (1985) Hypergastrinemia and colorectal carcinogenesis in the rat. Cancer Lett 29: 73–78

    Article  PubMed  CAS  Google Scholar 

  • Kennedy MFG, Tutton PJM, Barkla DH (1985) Adrenergic factors regulating cell division in the colonic crypt epithelium during carcinogenesis and in colonic adenoma and adenocarcinoma. Br J Cancer 52: 383–390

    Article  PubMed  CAS  Google Scholar 

  • Kijima-Suda I, Miyamoto Y, Toyoshima S, Itoh M, Osawa T (1986) Inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid: nucleoside conjugate having sialyltransferase inhibiting activity. Cancer Res 46: 858–862

    PubMed  CAS  Google Scholar 

  • Kim YS, Isaacs R (1975) Glycoprotein metabolism in inflammatory and neoplastic diseases of the human colon. Cancer Res 35: 2092–2097

    PubMed  CAS  Google Scholar 

  • Kim YS, Isaacs R, Perdomo JM (1974) Alterations of membrane glycopeptides in human colonic adenocarcinoma. Proc Natl Acad Sci USA 71: 4869–4873

    Article  PubMed  CAS  Google Scholar 

  • Kim YS, Whitehead JS, Perdomo J (1979) Glycoproteins of cultured epithelial cells from human colonic adenocarcinoma and fetal intestine. Eur J Cancer 15: 725–735

    PubMed  CAS  Google Scholar 

  • Kim YS, Yuan M, Itzkowitz SH, Sun Q, Kaizu T, Palekar A, Trump BF, Hakomori S (1986) Expression of Ley and extended Ley blood groups-related antigens in human malignant, premalignant and nonmalignant colonic tissues. Cancer Res 46: 5985–5992

    PubMed  CAS  Google Scholar 

  • Kingsnorth AN, King WW, Diekema KA, McCann PP, Ross JS, Malt RA (1983 a) Inhibition of ornithine decarboxylase with 2-difluoromethylornithine: reduced incidence of dimethylhydrazine-induced colon tumors in mice. Cancer Res 43: 2545–2549

    Google Scholar 

  • Kingsnorth AN, Russell WE, McCann PP, Diekema KA, Malt RA (1983b) Effects of a-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line. Cancer Res 43: 4035–4038

    PubMed  CAS  Google Scholar 

  • Kokal W, Sheibani K, Terz J, Horoda JR (1986) Tumor DNA content in the prognosis of colorectal carcinoma. JAMA 255: 3123–3127

    Article  PubMed  CAS  Google Scholar 

  • Koprowski H, Steplewski Z, Mitchell K, Herlyn M, Herlyn D, Fuhrer P (1979) Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet 5: 957–971

    Article  PubMed  CAS  Google Scholar 

  • Kornfeld R, Kornfeld S (1981) Structure of glycoproteins and their oligosaccharide units. In: Lennary WJ (ed) The biochemistry of glycoproteins and proteoglycans. Plenum, New York, pp 1–34

    Google Scholar 

  • Koss LG, Greenbaum E (1986) Measuring DNA in human cancer. JAMA 255:3158–3159 Kuhns WS, Schoentag R (1981) Carcinoma-related alterations of glycosyltransferascs in human tissue. Cancer Res 41: 2767–2772

    Google Scholar 

  • Kurosaka A, Nakajima H, Funakoshi 1, Matsuyama M, Nagayo T, Yamashina I (1983) Structure of the major oligosaccharides from a human rectal adenocarcinoma glycoprotein. J Biol Chem 258: 11594–11 598

    Google Scholar 

  • LaMont JT, Isselbacher KJ (1975) Alterations in glycosyltransferase activity in human colon cancer. J Natl Cancer Inst 54: 53–56

    PubMed  CAS  Google Scholar 

  • LaMont JT, O’Gorman TA (1978) Experimental colon cancer. Gastroenterology 75:1157–1169 LaMont JT, Weiser MM, Isselbacher KJ (1974) Cell surface glycosyltransferase activity in normal and neoplastic intestinal epithelium of the rat. Cancer Res 34: 3225–3228

    Google Scholar 

  • LaMurglia GM, Lacaine R, Malt RA (1986) High ornithine decarboxylase activity and poly- amine levels in human colorectal neoplasia. Ann Surg 204: 89–93

    Article  Google Scholar 

  • Langvad E (1968) Lactate dehydrogenese isoenzyme patterns in the tumor bearing colon. Int J Cancer 3: 17–29

    Article  PubMed  CAS  Google Scholar 

  • Lazarus P, Panasci LC (1987) Mechanism of decrease of protein synthesis by sodium cyanate in murine P388 leukemia cells. Cancer Res 47: 5102–5107

    PubMed  CAS  Google Scholar 

  • Levin B, Reichmann A (1986) Chromosomes and large bowel tumors. Cancer Genet Cytogenet 19: 159–162

    Article  PubMed  CAS  Google Scholar 

  • Levine AE, McRae U, Hamilton DA, Brattain DE, Yeoman LC, Brattain MG (1985) Identification of endogenous inhibitory growth factors from a human colon carcinoma cell line. Cancer Res 45: 2248–2254

    PubMed  CAS  Google Scholar 

  • Liotta LA (1986) Tumor invasion and metastasis — role of the extracellular matrix: Rhoads memorial lecture. Cancer Res 46: 1–7

    Article  PubMed  CAS  Google Scholar 

  • Liotta LA, Kleinerman J, Catanzara P, Gynbrandt D (1977) Degradation of basement membrane by murine tumor cells. J Natl Cancer Inst 58: 1427–1439

    PubMed  CAS  Google Scholar 

  • Luk GD, Hamilton SR, Yang P, Smith JA, O’Ceallaigh D, McAvinchey D, Hyland J (1986) Kinetic changes in mucosal ornithine decarboxylase activity during azoxymethane-induced colonic carcinogenesis in the rat. Cancer Res 46: 4449–4452

    PubMed  CAS  Google Scholar 

  • Luk GD, Silverman AL, Giardiello FM (1987) Biochemical markers in patients with familial colonic neoplasia. Semin Surg Oncol 3: 126–132

    Article  PubMed  CAS  Google Scholar 

  • Magnani JL, Nilsson B, Brockhaus M, Zopf D, Steplewski Z, Koprowski H, Ginsburg V (1982) A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J Biol Chem 257: 14365–14369

    PubMed  CAS  Google Scholar 

  • Magnani JL, Steplewski Z, Koprowski H, Ginsburg V (1983) Identification of the gastrointestinal and pancreatic associated antigen detected by monoclonal antibody 19–9 in the sera of patients as a mucin. Cancer Res 43: 5489–5492

    PubMed  CAS  Google Scholar 

  • Marks ME, Danbury BH, Miller CA, Brattain MG (1983) Cell surface proteins and glycoproteins from biologically different human colon carcinoma cell lines. J Natl Cancer Inst 71: 663–771

    PubMed  CAS  Google Scholar 

  • Matsushita Y, Yonezawa S, Nakamura T, Shimizu S, Ozawa M, Muramatsu T, Sato E (1985) Carcinoma-specific Ulex europaeus agglutinin-I binding glycoproteins of human colorectal carcinoma and its relation to carcinoembryonic antigen. J Natl Cancer Inst 75: 219–226

    PubMed  CAS  Google Scholar 

  • Matthews J, Cooke T (1986) Changes in crypt cell DNA content during experimental colonic carcinogenesis. Br J Cancer 53: 787–791

    Article  PubMed  CAS  Google Scholar 

  • McGinty F, Delides G, Harrison D (1973) The significance of enzyme histochemical patterns in carcinoma of the large intestine in man. Gut 14: 502–505

    Article  PubMed  CAS  Google Scholar 

  • McKinley M, Budman D, Caccese W, Weissman G, Scheidt N, Kahn E, Bronzo R (1985)

    Google Scholar 

  • Evaluation of colonic neoplasia by flow cytometry of endoscopie biopsies. Am J Gastroenterol 80:47–49

    Google Scholar 

  • Melamed MR, Enker WE, Banner P, Janov AJ, Kessler G, Darzynkiewicz Z (1986) Flow cytometry of colorectal carcinoma with three-year follow-up. Dis Colon Rectum 29: 184–186

    Article  PubMed  CAS  Google Scholar 

  • Mian N, Cowen DM (1974) Glycosidases in normal and dimethylhydrazine-treated rats and mice with special reference to the colonic tumors. Br J Cancer 29: 438–446

    Article  PubMed  CAS  Google Scholar 

  • Mian N, Herries DG, Cowen DM, Batte EA (1979) The multiple forms and kinetic properties of the N-acetyl-ß-D-hexosaminidases from colonic tumors and mucosa of rats treated with 1,2-dimethylhydrazine. Biochem J 177: 319–330

    PubMed  CAS  Google Scholar 

  • Moon RC, Fricks CM (1977) Influence of gonadal hormones and age on 1,2-dimethylhydrazine-induced colon carcinogenesis. Cancer 40: 2502–2508

    Article  PubMed  CAS  Google Scholar 

  • Moorehead RJ, Hoper M, McKelvey ST (1987) Assessment of ornithine decarboxylase activity in rectal mucosa as a marker of colorectal adenomas and carcinomas. Br J Surg 74: 364–365

    Article  PubMed  CAS  Google Scholar 

  • Mooseker MS (1985) Organization, chemistry and assembly of the cytoskeletal apparatus of the intestinal brush border. Annu Rev Cell Biol 1: 209–241

    Article  PubMed  CAS  Google Scholar 

  • Morris DR, Marton LJ (eds) (1981) Polyamines in biology and medicine. Dekker, New York

    Google Scholar 

  • Moshier JA, Luk GD, Huang RCC (1986) mRNA from human colon tumor and mucosa related to the pol gene of an endogenous A-type retrovirus. Biochem Biophys Res Commun 139: 1071–1077

    Google Scholar 

  • Nachlas MN, Hannibal MJ (1961) Histochemical observations of the polyp-carcinoma sequence. Surg Gynecol Obstet 112: 534–542

    PubMed  CAS  Google Scholar 

  • Narisawa T, Hosaka S, Niwa M (1985) Prostaglandin E2 counteracts the inhibition by indomethacin of rat colon ornithine decarboxylase induction by deoxycholic acid. Jpn J Cancer Res 76: 338–344

    PubMed  CAS  Google Scholar 

  • Nelson RL, Wilson W, Samelson SL, Khoobyarian N (1987) The interaction of retrovirus and chemical carcinogen in experimental colon carcinogenesis. Surgery 101: 172–175

    PubMed  CAS  Google Scholar 

  • Odagiri E, Jibiki K, Demura R, Shinozaki H, Nakamura S, Demura H, Suzuki H (1984) Steroid receptors and the distribution of IR-carcinoembryonic antigen in colon cancer. Dis Colon Rectum 27: 787–791

    Article  PubMed  CAS  Google Scholar 

  • Odagiri E, Jibiki K, Kato Y, Nakamura S, Oda S-I, Demura R, Demura H (1985) Steroid receptors in dimethylhydrazine-induced colon carcinogenesis. Cancer 56: 2627–2634

    Article  PubMed  CAS  Google Scholar 

  • O’Gorman TA, LaMont JT (1978) Glycoprotein synthesis and secretion in human colon cancers and normal colonic mucosa. Cancer Res 38: 2784–2789

    Google Scholar 

  • Olden K, Parnet JB, White SL (1982) Carbohydrate moieties of glycoproteins, a reevaluation of their function. Biochim Biophys Acta 650: 209–232

    Article  PubMed  CAS  Google Scholar 

  • Ong DE, Markert C, Chiu J-F (1978) Cellular binding proteins for vitamin A in colorectal adenocarcinoma of rat. Cancer Res 38: 4422–4426

    PubMed  CAS  Google Scholar 

  • Paraskeva C, Buckle BG, Sheer D, Wigley CB (1984) The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis soli patients. Int J Cancer 34: 49–56

    Article  PubMed  CAS  Google Scholar 

  • Paris H, Bouscarel B, Cortinovis C, Murat JC (1985) Growth-related variation of a-adrenergic receptivity in the HT 29 adenocarcinoma cell-line from human colon. FEBS Lett 184: 82–86

    Article  PubMed  CAS  Google Scholar 

  • Pegg AE, McCann PP (1982) Polyamine metabolism and function. Am J Physiol 243: C212 — C221

    PubMed  CAS  Google Scholar 

  • Petersen SE (1985) Flow cytometry of human colorectal tumors: nuclear isolation by detergent technique. Cytometry 6: 452–460

    Article  PubMed  CAS  Google Scholar 

  • Podolsky DK, Weiser MM, Westwood JC, Gammon M (1977) Cancer-associated serum galactosyltransferase activity. J Biol Chem 252: 1807–1813

    PubMed  CAS  Google Scholar 

  • Quirke P, Fozard JBJ, Dixon MF, Dyson JED, Giles GR, Bird CC (1986) DNA aneuploidy in colorectal adenomas. Br J Cancer 53: 477–481

    Article  PubMed  CAS  Google Scholar 

  • Quirke P, Dixon MF, Clayden AD, Durdey P, Dyson JED, Williams NS, Bird CC (1987) Prognostic significance of DNA aneuploidy and cell proliferation in rectal adenocarcinomas. J Pathol 151: 285–291

    Article  PubMed  CAS  Google Scholar 

  • Reichmann A, Martin P, Levin B (1981) Chromosomal banding patterns in human large bowel cancer. Int J Cancer 28: 431–440

    Article  PubMed  CAS  Google Scholar 

  • Reid PE, Culling CFA, Dunn WL, Ramey CW, Clay MG (1975) Differences in chemical composition between the epithelial glycoproteins of the upper and lower halves of rat colon. Can J Biochem 53: 1328–1332

    Article  PubMed  CAS  Google Scholar 

  • Reid PE, Owen DA, Dunn WL, Ramey CW, Lazosky, Clay MG (1985) Chemical and histochemical studies of normal and diseased human gastrointestinal tract. III. Changes in the histochemical and chemical properties of the epithelial glycoproteins in the mucosa close to colonic tumors. Histochem J 17: 171–181

    Google Scholar 

  • Rousset M, Paris H, Chevalier G, Terrain B, Murat J-C, Zweibaum A (1984) Growth-related enzymatic control of glycogen metabolism in cultured human tumor cells. Cancer Res 44: 154–160

    PubMed  CAS  Google Scholar 

  • Rozhin J, Wilson PS, Bull AW, Nigro ND (1984) Ornithine decarboxylase activity in the rat and human colon. Cancer Res 44: 3226–3230

    PubMed  CAS  Google Scholar 

  • Russell DH (1983) Clinical relevance of polyamines. CRC Crit Rev Clin Lab Sci 18: 261–311

    Article  CAS  Google Scholar 

  • Rybak SM, Fett JW, Yao Q-Z, Vallee BL (1987) Angiogenin mRNA in human tumor and normal cells. Biochem Biophys Res Commun 146: 1240–1248

    Article  PubMed  CAS  Google Scholar 

  • Sakamoto J, Furukawa K, Cordon-Cardo C, Yin BWT, Rettig WJ, Oettgen HF, Old LJ, Lloyd KO (1986) Expression of Lewis’, Lewis’, X and Y blood group antigens in human colonic tumors and normal tissue and in human tumor-derived cell lines. Cancer Res 46: 1553–1561

    Google Scholar 

  • Sakamoto S, Kuwa K, Tsukada K, Sagara T, Kasahara N, Okamoto R (1987) Relative activities of thymidylate synthetase and thymidine kinase in 1,2-dimethylhydrazine-induced colon carcinomas in rats. Carcinogenesis 8: 405–408

    Article  PubMed  CAS  Google Scholar 

  • Sakamoto S, Sagara T, Iwama T, Kawasaki T, Okamoto R (1985) Increased activities of thymidine kinase isozymes in human colon polyp and carcinoma. Carcinogenesis 6: 917–919

    Article  PubMed  CAS  Google Scholar 

  • Salo T, Liotta LA, Trggvason K (1983) Purification and characterization of a murine basement membrane collagen-degrading enzyme secreted by metastatic tumor cells. J Biol Chem 258: 3058–3063

    PubMed  CAS  Google Scholar 

  • Sani BP, Banerjee CK (1983) Cellular receptor mediation of the action of retinoic acid. In: Meyskens FL, Prasad KN (eds) Modulation and mediation of cancer by vitamins. Karger, Basel, pp 153–161

    Google Scholar 

  • Sani BP, Banerjee CK, Peckham JC (1980) The presence of binding proteins for retinoic acid and dihydrotestosterone in murine and human colon tumors. Cancer 46: 2421–2429

    Article  PubMed  CAS  Google Scholar 

  • Savage AP, Matthews JL, Ghatei MA, Cooke T, Bloom SR (1987) Enteroglucagon and experi- mental intestinal carcinogenesis in the rat. Gut 28: 33–39

    Article  PubMed  CAS  Google Scholar 

  • Saydjari R, Townsend CM, Barranco SC, Thompson JC (1987) Effects of cyclosporine and a-difluoromethylornithine on the growth of mouse colon cancer in vitro. Life Sci 40: 359–366

    Article  PubMed  CAS  Google Scholar 

  • Shamsuddin AKM, Trump BF (1981) Colon epithelium. I. Light microscopic, histochemical, and ultrastructural features of normal colon epithelium of male Fischer 344 rats. J Natl Cancer Inst 66: 375–388

    PubMed  CAS  Google Scholar 

  • Shi ZR, McIntyre LJ, Knowles BB, Solter D, Kim YS (1984) Expression of a carbohydrate differentiation antigen stage specific embryonic antigen 1 in human colonic adenocarcinoma. Cancer Res 44: 1142–1147

    PubMed  CAS  Google Scholar 

  • Shioda Y, Brown WR, Ahnen AJ (1987) Serial observations of colonic carcinogenis in the rat. Premalignant mucosa binds Ulex europeus agglutinin. Gastroenterology 92: 1–12

    PubMed  CAS  Google Scholar 

  • Shonk CE, Arison RN, Koven BJ, Majima H, Boxer GE (1965) Enzyme patterns in human tissues. III. Glycolytic enzymes in normal and malignant tissues of the colon and rectum. Cancer Res 25: 206–213

    Google Scholar 

  • Siddiqui B, Whitehead JS, Kim YS (1978) Glycosphingolipids in human colonic adenocarcinoma. J Biol Chem 253: 2168–2175

    PubMed  CAS  Google Scholar 

  • Singh P, Walker JP, Townsend CM, Thompson JC (1986) Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC-26) in BALB/c mice. Cancer Res 46: 1612–1616

    PubMed  CAS  Google Scholar 

  • Solomon E, Voss R, Hall V, Bodmer WF, Jass JR, Jeffreys AJ, Lucibello FC, Patel I, Rider SH (1987) Chromosome 5 allele loss in human colorectal carcinomas. Nature 328: 616–619

    Article  PubMed  CAS  Google Scholar 

  • Sporn MB, Roberts AB (1985) Autocrine growth factors and cancer. Nature 313: 745–747

    Article  PubMed  CAS  Google Scholar 

  • Sporn MB, Dunlop NM, Newton DL, Smith JM (1976) Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc 35: 1332–1338

    Google Scholar 

  • Stebbings WSL, Farthing MJG, Vinson GP, Northover JMA, Wood RFM (1986) Androgen receptors in rectal and colonic cancer. Dis Colon Rectum 29: 95–98

    Article  PubMed  CAS  Google Scholar 

  • Stevens RH, Loven DP (1980) Intracellular adenosine and guanosine 3’,5’-cyclic monophosphate concentrations in rat small and large bowel following a single and multiple exposure to 1,2-dimethylhydrazine. Cancer Lett 9: 151–159

    Article  PubMed  CAS  Google Scholar 

  • Stuart CA, Prince MJ, Peters EJ, Smith FE, Townsend CM, Poffenbarger PL (1986) Insulin receptor proliferation: a mechanism for tumor-associated hypoglycemia. J Clin Endocrinol Metab 63: 879–885

    Article  PubMed  CAS  Google Scholar 

  • Summerton J, Flynn M, Cooke T, Taylor I (1983) Bile acid receptors in colorectal cancer. Br J Surg 70: 549–551

    Article  PubMed  CAS  Google Scholar 

  • Summerton J, Goeting N, Trotter GA, Taylor I (1985) Effect of deoxycholic acid on the tumour incidence, distribution, and receptor status of colorectal cancer in the rat model. Digestion 31: 77–81

    Article  PubMed  CAS  Google Scholar 

  • Sun AS, Sepkowitz K, Geller SA (1981) A study of some mitochondrial and peroxisomal enzymes in human colonic adenocarcinoma. Lab Invest 44: 13–17

    PubMed  CAS  Google Scholar 

  • Sun Q, Siddiqui B, Nudelman E, Hakomori S, Ho JJL, Kim YS (1987) New murine monoclonal antibodies to a human colonic cancer-associated glycolipid, extended difucosylated Ley glycolipid. Cancer J 1: 213–221

    CAS  Google Scholar 

  • Sunkara PS, Rao PN, Nishioka K, Brinkley BR (1979) Role of polyamines in cytokinesis of mammalian cells. Exp Cell Res 119: 63–68

    Article  PubMed  CAS  Google Scholar 

  • Suzuki H, Umehara N (1986) Early mucosal changes in dimethylhdrazine-induced colonic carcinogenesis in rats. Jpn J Surg 16: 140–143

    Article  PubMed  CAS  Google Scholar 

  • Suzuki H, Honda E, Matsumoto K, Iriyama K (1985) Tissue CEA determination and cytophotometric DNA analysis of colorectal mucosa in patients with colorectal cancer. Jpn J Surg 15: 449–454

    Article  PubMed  CAS  Google Scholar 

  • Takano S, Matsushima M, Erturk E, Bryan GT (1981) Early induction of rat colonic epithelial ornithine and S-adenosyl-L-methionine decarboxylase activities by N-methyl-N’-nitro-Nnitrosoguanidine or bile salts. Cancer Res 41: 624–628

    PubMed  CAS  Google Scholar 

  • Talpaz M, Plager C, Quesada J, Benjamin R, Kantarjian H, Gutterman J (1986) Difluoromethylornithine and leukocyte interferon: a phase I study in cancer patients. Eur J Cancer Clin Oncol 22: 685–689

    Article  PubMed  CAS  Google Scholar 

  • Tempero M (1986) Bile acids, ornithine decarboxylase, and cell proliferation in colon cancer: a review. Dig Dis 4: 49–56

    Article  PubMed  CAS  Google Scholar 

  • Ten Kate J, Van Den Ingh HFGM, Khan PM, Bosman FT (1986) Adenosine deaminase complexing protein ( ADCP) immunoreactivity in colorectal adenocarcinoma. Int J Cancer 37: 479–485

    Google Scholar 

  • Tricoli JV, Rall LB, Karakousis CP, Herrera L, Petrelli NJ, Bell GI, Shows TB (1986) Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas. Cancer Res 46: 6169–6173

    PubMed  CAS  Google Scholar 

  • Trotta PP, Balis ME (1977) Enzyme variants in normal and neoplastic intestinal mucosa. Cancer 40: 2592–2599

    Article  PubMed  CAS  Google Scholar 

  • Tsao D, Freeman HJ, Kim YS (1979) ß-Hexosaminidase isoenzymes in tissues, cultured cells, and media from human fetal intestine and colonic adenocarcinoma. Cancer Res 39: 3405–3410

    PubMed  CAS  Google Scholar 

  • Tutton PJM, Barkla DH (1982) The influence of androgens, antiandrogens, and castration on cell proliferation in the jejunal and colonic crypt epithelia, and in dimethylhydrazine-induced adenocarcinoma of rat colon. Virchows Arch [B] 38: 351–355

    Article  CAS  Google Scholar 

  • Tutton PJM, Barkla DH (1986) Comparison of the effects of an ornithine decarboxylase inhibitor on the intestinal epithelium and on intestinal tumors. Cancer Res 46:6091–6094 Warburg 0 (1956) On the origin of cancer cells. Science 123: 309–314

    Google Scholar 

  • Wattenberg LW (1959) A histochemical study of five oxidative enzymes in carcinoma of the large intestine in man. Am J Pathol 35: 113–137

    PubMed  CAS  Google Scholar 

  • Weber G (1977) Enzymology of cancer cells. N Engl J Med 296: 486–493

    Article  PubMed  CAS  Google Scholar 

  • Weber G, Kizaki H, Tzeng D, Shiotani T, Olah E (1978) Colon tumor: enzymology of the neoplastic program. Life Sci 23: 729–736

    Article  PubMed  CAS  Google Scholar 

  • Weber G, Lui MS, Takeda E, Denton JE (1980) Enzymology of human colon tumors. Life Sci 27: 793 — 799

    Google Scholar 

  • Weiner HL, Weiner LH, Swain JL (1987) Tissue distribution and developmental expression of the messenger RNA encoding angiogenin. Science 237: 280–282

    Article  PubMed  CAS  Google Scholar 

  • Weiser MM, Podolsky DK, Isselbacher KJ (1976) Cancer-associated isoenzyme of serum galactosyltransferase. Proc Natl Acad Sci USA 73: 1319–1327

    Article  PubMed  CAS  Google Scholar 

  • Whitehead JS, Fearney FJ, Kim YS (1979) Glycosyltransferase and glycosidase activities in cultured human fetal and colonic adenocarcinoma cell lines. Cancer Res 39: 1259–1263

    PubMed  CAS  Google Scholar 

  • Wice BM, Trugnan G, Pinto M, Rousset M, Chevalier G, Dussaulx E, Lacroix B, Zweibaum A (1985) The intracellular accumulation of UDP-N-adenylhexosamine is concomitant with the mobility of human colon cancer cells to differentiate. J Biol Chem 260: 139–146

    PubMed  CAS  Google Scholar 

  • Wiley EL, Mendelsohn G, Eggleston JC (1981) Distribution of carcinoembryonic antigens and blood group substances in adenocarcinoma of the colon. Lab Invest 44: 507–513

    PubMed  CAS  Google Scholar 

  • Winsett 0E, Townsend CM, Glass EJ, Rae-Venter B, Thompson JC (1986) Gastrin stimulates growth of colon cancer. Surgery 99: 302–307

    Google Scholar 

  • Wobbes T, Beex LV, Koenders AM (1984) Estrogen and progestin receptors in colonic cancer? Dis Colon Rectum 27: 591–592

    Article  PubMed  CAS  Google Scholar 

  • Yamakawa T, Nagai Y (1978) Glycolipids at the cell surface and their biological significance. Trends Biochem Sci 3: 128–131

    Article  CAS  Google Scholar 

  • Yeger H, Baumal R, Kahn HJ, Duwe G, Phillips MJ (1986) The use of cytoskeletal characteristics of tumor cells for the diagnosis of colon and breast adenocarcinomas. Am J Clin Pathol 86: 697–705

    PubMed  CAS  Google Scholar 

  • Yonezawa S, Nakamura T, Tanaka S, Sato E (1982) Glycoconjugate with Ulex europaeus agglutinin-1-binding sites in normal mucosa, adenoma, and carcinoma of the human large bowel. J Natl Cancer Inst 69: 777–785

    PubMed  CAS  Google Scholar 

  • Yonezawa S, Nakamura T, Tanaka S, Moruta K, Nishi M, Sato E (1983) Binding of Ulex europeaus agglutinin 1 in polyposis coli: comparative study with solitary adenocarcinoma in the sigmoid colon and rectum. J Natl Cancer Inst 71: 19–24

    PubMed  CAS  Google Scholar 

  • Youakim A, Herscovics A (1985) Cell surface glycopeptides from human intestinal epithelial cell lines derived from normal colon and colon adenocarcinomas. Cancer Res 45: 5505–5511

    PubMed  CAS  Google Scholar 

  • Yuan M, Itzkowitz SH, Boland CR, Kim YD, Tomita JT, Polekas A, Bennington JL, Trump BJ, Kim YS (1986) Comparison of T-antigen expression in normal, premalignant, and malignant human colonic tissue using lectin and antibody immunohistochemistry. Cancer Res 46: 4841–4847

    PubMed  CAS  Google Scholar 

  • Yuan M, Itzkowitz SH, Ferrell LD, Fukushi Y, Palekar A, Hakomori S, Kim YS (1987) Expression of Lewis’ and sialylated Lewis“ antigens in human colorectal polyps. J Natl Cancer Inst 78: 479–488

    PubMed  CAS  Google Scholar 

  • Yuan M, Itzkowitz SH, Palekar A, Shamsuddin AM, Phelps PC, Trump BF, Kim YS (1985) Distribution of blood group antigens A, B, H, Lewis’, and Lewisb in human normal, fetal, and malignant colonic tissue. Cancer Res 45: 4499–4511

    PubMed  CAS  Google Scholar 

  • Zweibaum A, Pinto M, Chevalier G, Dussaulx E, Triadau N, Lacroix B, Haffen K, Brun J-L, Roussel M (1985) Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT-29 selected for growth in sugar-free medium and its inhibition by glucose. J Cell Physiol 122: 21–29

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Toribara, N.W., Ho, S.B., Bresalier, R.S., Kim, Y.S. (1989). Biochemical Changes in Colorectal Carcinogenesis. In: Seitz, H.K., Simanowski, U.A., Wright, N.A. (eds) Colorectal Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85930-4_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85930-4_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85932-8

  • Online ISBN: 978-3-642-85930-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics