Serum Levels of Phenytoin in Children

  • H. Berlet


Notwithstanding the satisfactory average relationship between drug dose and serum concentrations, individual levels of phenytoin (diphenylhydantoin, DPH) may vary greatly with a given dose per kg body weight (Janz et al., 1975; Remmer et al., 1969; Buchanan et al., 1972). This appears to hold especially for children (Borofsky et al., 1972; Buchanan et al., 1971), with very low elimination rates of the drug possibly accounting for occasional striking disparities between administered dose of DPH and high serum levels (Gauchel et al., 1973). These observations have prompted an evaluation of analytical data obtained from children treated with DPH for the control of epileptic seizures. Of particular interest were the relationship between oral DPH dose and serum levels, and daily fluctuations of serum DPH levels in children receiving DPH in divided daily doses.


Elimination Rate High Serum Level Daily Fluctuation Fast Group Slow Group 
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Copyright information

© Springer-Verlag Berlin-Heidelberg 1975

Authors and Affiliations

  • H. Berlet
    • 1
  1. 1.Institute of Pathochemistry and General NeurochemistryHeidelbergFederal Republic of Germany

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