Evaluation of an Experimental Homogeneous Enzyme Immuno-Assay for the Quantitation of Phenytoin and Phenobarbitone in Serum or Plasma

  • Ch. E. Pippenger
  • R. J. Bastiani
  • R. S. Schneider


Since the first reports on the relationship of serum anti-epileptic drug concentrations to seizure control, the goal of the pharmacologist and clinical chemist has been to provide rapid and accurate drug level determinations to the clinician. The application of gas liquid chromatography (GLC) to the detection of several anti-epileptic drugs in the same serum sample in 1969 and the marked increase in the number of GLC methods available has greatly enhanced our ability to achieve adequate seizure control (in epileptic patients). Extensive reviews of anti-epileptic drug methodology (Rose et al., 1971; Meijer et al., 1973), and of the application of blood levels to seizure control (Woodbury et al., 1972; Kutt and Louis, 1972) have been published.


Barbituric Acid Immunoassay System Emit System Tris Hydrochloride Enzyme Immunoassay System 
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Copyright information

© Springer-Verlag Berlin-Heidelberg 1975

Authors and Affiliations

  • Ch. E. Pippenger
    • 1
    • 2
  • R. J. Bastiani
    • 3
  • R. S. Schneider
    • 3
  1. 1.Department of Neurology College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  2. 2.Clinical Chemistry ServiceThe Presbyterian HospitalNew YorkUSA
  3. 3.Syva Research InstitutePalo AltoUSA

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