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Evaluation of an Experimental Homogeneous Enzyme Immuno-Assay for the Quantitation of Phenytoin and Phenobarbitone in Serum or Plasma

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Book cover Clinical Pharmacology of Anti-Epileptic Drugs

Abstract

Since the first reports on the relationship of serum anti-epileptic drug concentrations to seizure control, the goal of the pharmacologist and clinical chemist has been to provide rapid and accurate drug level determinations to the clinician. The application of gas liquid chromatography (GLC) to the detection of several anti-epileptic drugs in the same serum sample in 1969 and the marked increase in the number of GLC methods available has greatly enhanced our ability to achieve adequate seizure control (in epileptic patients). Extensive reviews of anti-epileptic drug methodology (Rose et al., 1971; Meijer et al., 1973), and of the application of blood levels to seizure control (Woodbury et al., 1972; Kutt and Louis, 1972) have been published.

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References

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Author information

Authors and Affiliations

  1. Department of Neurology College of Physicians and Surgeons, Columbia University, New York, NY, USA

    Ch. E. Pippenger

  2. Clinical Chemistry Service, The Presbyterian Hospital, New York, NY, USA

    Ch. E. Pippenger

  3. Syva Research Institute, Palo Alto, California, USA

    R. J. Bastiani & R. S. Schneider

Authors
  1. Ch. E. Pippenger
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  2. R. J. Bastiani
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  3. R. S. Schneider
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Editor information

Editors and Affiliations

  1. Neurophysiol. Abtlg., Ges. f. Epilepsie-Fschg. e. V., 48 Bielefeld 13, Bethel, Maraweg 13, Germany

    H. Schneider

  2. Abteilung für Neurologie im Klinikum Charlottenburg, Freien Universität Berlin, Spandauer Damm 130, D-l, Berlin 19 (West), Germany

    D. Janz

  3. Exeter & Mid-Devon Hospitals, Royal Devon & Exeter Hospitals (Wonford), Barrack Road, EX2 5DW, Exeter, England

    C. Gardner-Thorpe M. D.

  4. Instituut voor Epilepsiebestrijding, Achterweg 5, Heemstede, The Netherlands

    H. Meinardi Ph. D.

  5. Montreal Neurological Institute, 3801 University Street, Montreal 112, Quebec, Canada

    A. L. Sherwin Ph. D.

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© 1975 Springer-Verlag Berlin-Heidelberg

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Pippenger, C.E., Bastiani, R.J., Schneider, R.S. (1975). Evaluation of an Experimental Homogeneous Enzyme Immuno-Assay for the Quantitation of Phenytoin and Phenobarbitone in Serum or Plasma. In: Schneider, H., Janz, D., Gardner-Thorpe, C., Meinardi, H., Sherwin, A.L. (eds) Clinical Pharmacology of Anti-Epileptic Drugs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85921-2_35

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  • DOI: https://doi.org/10.1007/978-3-642-85921-2_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85923-6

  • Online ISBN: 978-3-642-85921-2

  • eBook Packages: Springer Book Archive

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