Comparison of Methods for Determination of Drugs in Serum and Plasma

  • E. Riedel
  • U. Krüger
  • H. Bayer
  • H. Horak
Conference paper

Abstract

At a workshop on the determination of anti-epileptic drugs with a predominantly clinical view point, there should be some discussion about the problems of laboratory practice and laboratory routine. The output of an analytical laboratory in a hospital with mainly epileptic patients must be orientated on the medical problems of the clinical departments. These problems can be of quite different make-up. Fig. 1 shows the frequency of drugs in blood samples of patients of an outpatient clinic and of an epilepsy centre hospital, the latter with the most complicated cases. From the great number of anti-epileptic drugs in use the serum levels of phenytoin (DPH), phenobarbitone (PB) and carbamazepine (CBZ) are of the greatest interest. These also have the highest frequency in our analyses (Fig. 2). Then follow succinimides (SUX), dipropylacetate (Ergenyl®, E), sulthiame (Ospolot®, O) and diazepam (Valium®, V), haloperidol (Haloperidol-Janssen®, HAL) and other neuroleptic drugs and psychopharmaceuticals.

Keywords

Carbamazepine Haloperidol Phenanthrene Phenobarbitone Stigmasterol 

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References

  1. Kupferberg, H. J.: Quantitative estimation of diphenylhydantoin, primidone and phenobarbital in plasma by gasliquid chromatography. Clin. chim. Acta 29, 283 (1970).CrossRefGoogle Scholar
  2. Meijer, J. W. A.: Simultaneous quantitative determination of anti-epileptic drugs, including carbamazepine, in body fluids. Epilepsia (Amst.) 12, 341 (1971).CrossRefGoogle Scholar
  3. Svensmark, O., Kristensen, P.: Determination of diphenylhydantoin and phenobarbital in small amounts of serum. J. Lab. clin. Med. 61, 501 (1963).PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin-Heidelberg 1975

Authors and Affiliations

  • E. Riedel
    • 1
  • U. Krüger
    • 1
  • H. Bayer
    • 1
  • H. Horak
    • 1
  1. 1.Zentralinstitut für Biochemie und Biophysik, Biochemisches Laboratorium der Ges. f. EpilepsieforsdiungFreien Universität BerlinBethel/BielefeldW. Germany

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