Comparison of Methods for Determination of Drugs in Serum and Plasma
At a workshop on the determination of anti-epileptic drugs with a predominantly clinical view point, there should be some discussion about the problems of laboratory practice and laboratory routine. The output of an analytical laboratory in a hospital with mainly epileptic patients must be orientated on the medical problems of the clinical departments. These problems can be of quite different make-up. Fig. 1 shows the frequency of drugs in blood samples of patients of an outpatient clinic and of an epilepsy centre hospital, the latter with the most complicated cases. From the great number of anti-epileptic drugs in use the serum levels of phenytoin (DPH), phenobarbitone (PB) and carbamazepine (CBZ) are of the greatest interest. These also have the highest frequency in our analyses (Fig. 2). Then follow succinimides (SUX), dipropylacetate (Ergenyl®, E), sulthiame (Ospolot®, O) and diazepam (Valium®, V), haloperidol (Haloperidol-Janssen®, HAL) and other neuroleptic drugs and psychopharmaceuticals.
KeywordsEpileptic Patient Neuroleptic Drug Peak Internal Standard Artefact Peak Stationary Separation Phase
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