Carbamazepine: The Influence of Other Anti-Epileptic Drugs on its Serum Level

  • H. Schneider


The interactions between various anti-epileptic drugs have been reported on from time to time (Hansen et al. (1968), Cucinell et al. (1965), Kutt et al. (1969), Morselli et al. (1971) etc.). In the case of carbamazepine, its action on the serum concentration of phenytoin has been recognized previously (Hansen et al. (1971)).


Regression Line Metabolic Conversion Carbamazepine Concentration Carbamazepine Treatment Carbamazepine Dosage 
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  1. Cereghino, J. J., van Meter, J. T., Penry, J. K., Smith, L. D., White, B. G.: Preliminary observations of serum carbamazepine concentration in epileptic patients. Neurology (Minneap.) 23, 357 (1973).Google Scholar
  2. Christiansen, J., Dam, M.: Influence of phenobarbital and diphenylhydantoin on plasma carbamazepine levels in patients with epilepsy. Acta neurol. scand. 49, 543 (1973).PubMedCrossRefGoogle Scholar
  3. Cucinell, S. A., Conney, A. H., Sansur, M., Burns, J. J.: Drug interactions in man. I. Lowering effect of phenobarbital on plasma levels of bishydroxycoumarin (Dicumarol®) and diphenylhydantoin (Dilantin®). Clin. Pharmacol. Ther. 6, 420 (1965).PubMedGoogle Scholar
  4. Frey, H.: Serum concentrations of carbamazepine in adults. In: Konferens Plasmakoncentra- tions-Bestämningar av Antiepileptika: Metodologiska odi Kliniska Aspekter, Lidingö 1971 (Referat av Lars Lund), pp. 68–70 Mölndal: Geigy Läkemedel 1971.Google Scholar
  5. Hansen, J. M., Kristensen, M., Skovsted, L.: Sulthiame (Ospolot®) as inhibitor of diphenylhydantoin metabolism. Epilepsia 9, 17 (1968).PubMedCrossRefGoogle Scholar
  6. Hansen, J. M., Siersbaek-Nielsen, K., Skovsted, L.: Carbamazepine induced acceleration of diphenylhydantoin and warfarin metabolism in man. Clin. Pharmacol. Ther. 12, 539 (1971).PubMedGoogle Scholar
  7. Herrmann, B.: Personal communication (1964).Google Scholar
  8. Kutt, H., Haynes, J., Verebely, K., McDowell, F.: The effect of phenobarbital on plasma diphenylhydantoin level and metabolism in man and in rat liver microsomes. Neurology (Minneap.) 19, 611 (1969).Google Scholar
  9. Morselli, P. L., Rizzo, M., Garattini, S.: Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients. Ann. N. Y. Acad. Sci. 179, 88 (1971).PubMedCrossRefGoogle Scholar
  10. Ostle, B.: Statistics in Research, p. 201. 2nd Edition, Iowa State University Press 1963.Google Scholar
  11. Schneider, H.: Carbamazepine: An attempt to correlate serum levels with anti-epileptic and side-effects. In: Clinical Pharmacology of Anti-Epileptic Drugs (Eds. H. Schneider, D. Janz, C. Gardner-Thorpe, H. Meinardi, A. L. Sherwin), p. 151. Berlin-Heidelberg-New York: Springer 1975.Google Scholar

Copyright information

© Springer-Verlag Berlin-Heidelberg 1975

Authors and Affiliations

  • H. Schneider
    • 1
  1. 1.Neurophysiol. AbteilungGesellschaft für EpilepsieforschungBielefeld-BethelFederal Republic of Germany

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