Abstract
The interactions between various anti-epileptic drugs have been reported on from time to time (Hansen et al. (1968), Cucinell et al. (1965), Kutt et al. (1969), Morselli et al. (1971) etc.). In the case of carbamazepine, its action on the serum concentration of phenytoin has been recognized previously (Hansen et al. (1971)).
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References
Cereghino, J. J., van Meter, J. T., Penry, J. K., Smith, L. D., White, B. G.: Preliminary observations of serum carbamazepine concentration in epileptic patients. Neurology (Minneap.) 23, 357 (1973).
Christiansen, J., Dam, M.: Influence of phenobarbital and diphenylhydantoin on plasma carbamazepine levels in patients with epilepsy. Acta neurol. scand. 49, 543 (1973).
Cucinell, S. A., Conney, A. H., Sansur, M., Burns, J. J.: Drug interactions in man. I. Lowering effect of phenobarbital on plasma levels of bishydroxycoumarin (Dicumarol®) and diphenylhydantoin (Dilantin®). Clin. Pharmacol. Ther. 6, 420 (1965).
Frey, H.: Serum concentrations of carbamazepine in adults. In: Konferens Plasmakoncentra- tions-Bestämningar av Antiepileptika: Metodologiska odi Kliniska Aspekter, Lidingö 1971 (Referat av Lars Lund), pp. 68–70 Mölndal: Geigy Läkemedel 1971.
Hansen, J. M., Kristensen, M., Skovsted, L.: Sulthiame (Ospolot®) as inhibitor of diphenylhydantoin metabolism. Epilepsia 9, 17 (1968).
Hansen, J. M., Siersbaek-Nielsen, K., Skovsted, L.: Carbamazepine induced acceleration of diphenylhydantoin and warfarin metabolism in man. Clin. Pharmacol. Ther. 12, 539 (1971).
Herrmann, B.: Personal communication (1964).
Kutt, H., Haynes, J., Verebely, K., McDowell, F.: The effect of phenobarbital on plasma diphenylhydantoin level and metabolism in man and in rat liver microsomes. Neurology (Minneap.) 19, 611 (1969).
Morselli, P. L., Rizzo, M., Garattini, S.: Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients. Ann. N. Y. Acad. Sci. 179, 88 (1971).
Ostle, B.: Statistics in Research, p. 201. 2nd Edition, Iowa State University Press 1963.
Schneider, H.: Carbamazepine: An attempt to correlate serum levels with anti-epileptic and side-effects. In: Clinical Pharmacology of Anti-Epileptic Drugs (Eds. H. Schneider, D. Janz, C. Gardner-Thorpe, H. Meinardi, A. L. Sherwin), p. 151. Berlin-Heidelberg-New York: Springer 1975.
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Schneider, H. (1975). Carbamazepine: The Influence of Other Anti-Epileptic Drugs on its Serum Level. In: Schneider, H., Janz, D., Gardner-Thorpe, C., Meinardi, H., Sherwin, A.L. (eds) Clinical Pharmacology of Anti-Epileptic Drugs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85921-2_18
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DOI: https://doi.org/10.1007/978-3-642-85921-2_18
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