Some Problems Concerning the Quantitative Assay of Primidone and Its Metabolites

  • H. R. Schäfer


All pharmacokinetic studies dealing with primidone therapy are complicated because phenobarbitone and phenylethylmalondiamide (PEMA) are the main metabolites of the biotransformation of primidone.


Partition Coefficient Quantitative Assay System Chloroform Suitable Internal Standard Lipophilic Phase 
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Copyright information

© Springer-Verlag Berlin-Heidelberg 1975

Authors and Affiliations

  • H. R. Schäfer
    • 1
  1. 1.Chemisch-pharmazeutisches LaboratoriumDesitin-Werk Carl Klinke G.m.b.H.Hamburg 63Federal Republic of Germany

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