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Pathophysiology

  • Michael Böhm
  • Erland Erdmann
Chapter

Abstract

The final path common to the most mechanisms contibuting to the regulation of the myocardial contractile force is the modulation of the intracellular calcium concentration. The electromechanical coupling of the myocardial cell are biophysical and biochemical processes occurring between the electrical excitation of the cell membrane and the contraction of the individual myocyte. Starting from a membrane potential of about -90 mV the myocyte depolarizes after activation by the action potential and voltage-dependent calcium channels open. Ion channels such as the calcium channel are specific proteins which span the membrane, form pores and in an open state selectively permit ions to enter into the cell.

Keywords

Heart Failure Chronic Heart Failure Sarcoplasmic Reticulum Plasma Renin Activity Contractile Force 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Michael Böhm
    • 1
  • Erland Erdmann
    • 1
  1. 1.Klinik III für Innere MedizinUniversität zu KölnKölnGermany

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