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Impaired Calcium Homeostasis and Calcium Antagonists in Muscle Diseases

  • S. Zierz
Conference paper

Abstract

The electrical excitation of the muscle plasma membrane following a nerve impulse spreads into the T-tubule system. The electrical signal is then transferred to the sarcoplasmic reticulum, and large amounts of Ca2+ stored in its lumen are released into the cytosol. In the resting state at low cytosolic Ca2+ concentrations (about 10−7 M), tropomyosin sterically blocks the interaction of myosin heads with actin. When the cytosolic Ca2+ level is raised up to 10−5 M following the electrical excitation, free Ca2+ interacts with troponin, resulting in a conformational change of the tropomyosin, allowing the myosin heads to interact with actin. Subsequently, the Ca2+ concentrations of the myofibrillar compartment are rapidly restored to the resting level by uptake of Ca2+ into the sarcoplasmic reticulum through the Ca2+-Mg2+ ATPase located in the sarcoplasmic reticulum [19].

Keywords

Sarcoplasmic Reticulum Calcium Antagonist Duchenne Muscular Dystrophy Malignant Hyperthermia Myotonic Dystrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • S. Zierz
    • 1
  1. 1.Neurologische Universitätsklinik BonnBonnGermany

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