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Blood-Brain Barrier Permeability to Micromolecules After Focal Cerebral Ischemia

  • S. Sampaolo
  • N. Heye
  • J. Cervos-Navarro
Conference paper

Abstract

During the initial 1–6 h of ischemia the blood-brain barrier (BBB) is grossly impermeable to protein tracers such as Evans blue (EB) [9–11, 19]. Tissue water content in ischemic brain increases within the first 2 h of arterial occlusion [8–10, 19, 21] and a significant decrease of the specific gravity of the ischemic frontal cortex has been reported as early as 30 min after permanent middle cerebral artery (MCA) occlusion in the rat [22]. Fluid accumulation is believed to occur in response to an increase of sodium into the lesion site [27] or reduction in sodium clearance from the tissue [12].

Keywords

Methylene Blue Focal Cerebral Ischemia Evans Blue Piriform Cortex Sodium Fluorescein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • S. Sampaolo
    • 1
  • N. Heye
    • 1
  • J. Cervos-Navarro
    • 1
  1. 1.Institute of Neuropathology, Universitätsklinikum SteglitzFree University of BerlinBerlin 45Germany

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