Studies on the Efficacy and Mechanism of Action of a Calcium Blocker After Global Ischemia

  • D. M. Rosenbaum
  • J. C. Grotta
  • F. M. Yatsu
  • L. C. Pettigrew
Conference paper


After numerous studies of calcium channel blockers, the efficacy and mechanism of action are still debated [1, 2, 7,10,11,16,17, 21, 22, 24, 28, 29]. Two possible mechanisms have been proposed for their beneficial effect: (a) relaxation of vascular smooth muscle and increase in cerebral blood flow, and (b) prevention of calcium flux into neurons, thereby limiting activation of phospholipases, proteases, and consequent membrane and protein degradation and production of damaging metabolic by-products such as free radicals [3–5,15, 20, 23, 25, 26, 30].


Cerebral Blood Flow Mean Arterial Blood Pressure Cereb Blood Flow Forebrain Ischemia Cerebral Blood Flow Baseline 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • D. M. Rosenbaum
    • 1
  • J. C. Grotta
    • 1
  • F. M. Yatsu
    • 1
  • L. C. Pettigrew
    • 1
  1. 1.Department of NeurologyThe University of Texas Medical School at HoustonHoustonUSA

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