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Review of Flunarizine in Epilepsy

  • C. D. Binnie
  • F. de Beukelaar
  • J. Overweg
Conference paper

Abstract

A feature of epileptogenesis is burst firing of individual neurons. The burst comprises a slow paroxysmal depolarizing ion shift (PDS) upon which is superimposed a train of action potentials [6, 36]. Bursting depends largely on influx of Ca2+, although other ionic currents are also involved [37, 56].

Keywords

Calcium Antagonist Concentration Of30 Tonic Seizure Calcium Entry Blocker Paroxysmal Depolarization Shift 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • C. D. Binnie
    • 1
  • F. de Beukelaar
    • 2
  • J. Overweg
    • 3
  1. 1.The Maudsley HospitalLondonUK
  2. 2.Janssen Pharmaceutica B.V.B-BeerseBelgium
  3. 3.Instituut voor EpilepsiebestrijdingHeemstedeThe Netherlands

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