Abstract
A number of pharmacological agents have recently become available that are capable of limiting or blocking calcium passage through cellular membrane channels. These drugs are termed calcium antagonists or calcium channel or calcium entry blockers. Cell membranes of smooth muscle and nerve cells have several different calcium channels which may be selectively altered by calcium channel blockers [28, 29]. Since the cellular entry of calcium initiates contraction of vascular smooth muscle, calcium channel blockers exert both antispasmodic and slight vasodilator actions [6]. Calcium channels are susceptible to ischemia resulting in calcium entry with intracellular “overload”, which may be responsible for cell damage and eventually cell death [7, 26]. Calcium antagonists also exert protective actions against ischemic and anoxic damage to both nerve cells and smooth muscle.
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References
Ad Hoc Committee on Classification of Headache (1962) Classification of headache. JAMA 179:717–718
Amery WK, Caers LI, Aerts TJL (1985) Flunarizine, a calcium entry blocker in migraine prophylaxis. Headache 25:249–254
Amery WK, Wauquier A, Van Nueten JM, DeClerck F, Van Reempts JV, Janssen PAJ (1981) The anti-migrainous pharmacology of flunarizine (R14950), a calcium antagonist. Drugs Exp Clin Res VII(1):1–10
Antman E, Muller J, Goldberg S et al. (1980) Nifedipine therapy for coronary-artery spasm. N Engl J Med 302:1269–1273
Bussone G, Baldini S, D’Andréa G et al. (1987) Nimodipine vs flunarizine in common migraine. A controlled pilot trial. Headache 27:76–79
Cauvin C, Loutzenhiser R, Van Breemen C (1983) Mechanism of calcium antagonist induced vasodilation. Ann Rev Pharmacol Toxicol 23:373–396
Diamond S, Schenbaum H (1983) Flunarizine, a calcium channel blocker, in the prophylactic treatment of migraine. Headache 23:39–42
Farber JL (1981) The role of calcium in cell death. Life Sci 29:1289–1295
Flaim SF (1982) Comparative pharmacology of calcium blockers, based on studies of vascular smooth muscle. In: Flaim SF, Zolis R (eds) Calcium blockers: mechanism of action and clinical application. Urban & Schwarzenberg, Baltimore, pp 155–178
Fleckenstein A (1964) Die Bedeutung der energiereichen Phosphate für Kontraktiiitat und Tonus des Myokards. Verh Dtsch Ges Inn Med 70:81–89
Fleckenstein A (1977) Specific pharmacology of calcium in myocardia, cardiac pacemakers and vascular smooth muscle. Annu Rev Pharmacol Toxicol 17:149–166
Fleckenstein A, Tritthart H, Fleckenstein B, Herbst A, Grun B (1969) A new group of competitive calcium antagonists (Iproveratril, D600, prenylaine) with highly potent inhibitory effect on excitation/conduction coupling in mammalian myocardium. Pflügers Arch 307:R25
Freedman SB, Dawson G, Villareal ML, Miller RJ (1984) Identification and characterization of voltage-sensitive calcium channels in neuronal clonal cell lines. J Neurosci 4:1453–1467
Gelmers HJ (1983) Nimodipine, a new calcium antagonist in the prophylactic treatment of migraine. Headache 23:106–109
Havanka-Kanniaiken H, Hokkanen E, Myllyla VV (1985) Efficacy of nimodipine in the prophylaxis of migraine. Cephalalgia 5(1):39–43
Havanka-Kanniaiken H, Myllyla VV, Hokkanen E (1982) Nimodipine in the prophylaxis of migraine, a double-blind study. Acta Neurol Scand 65(Suppl 90):77–78
Jonsdottir M, Meyer JS, Rogers RL (1987) Efficacy, side effects and tolerance compared during headache treatment with three different calcium blockers. Headache 27:364–369
Kahan A, Weber S, Amor B, Guerin F, Degeorge M (1983) Nifedipine in the treatment of migraine in patients with Raynauds’ phenomenon (letter). N Eng J Med 308:1102–1103
Louis P (1981) A double-blind placebo-controlled prophylactic study of flunarizine (Sibelium) in migraine. Headache 21:235–239
Louis P, Spierings ELH (1982) Comparison of flunarizine (Sibelium) and pizotifen (Sandomigran) in migraine treatment. Cephalalgia 2:197–203
McGoon M, Vlietstra R, Holmes D, Osborn JE (1982) The clinical use of verapamil. Mayo Clin Proc 57:495–510
Markley HG, Cheronis JCD, Piepho RW (1984) Verapamil in prophylactic therapy of migraine. Neurology 34:963–976
Meyer JS, Dowell R, Mathew N, Hardenberg J (1984) Clinical and hemodynamic treatment of vascular headaches with verapamil. Headache 24:313–321
Meyer JS, Hardenberg J (1983) Clinical effectiveness of calcium entry blockers in prophylactic treatment of migraine and cluster headaches. Headache 23:266–277
Micieli G, Trucco M, Agostinis C, Mancuso A, Papalia F, Sinforiani E (1985) Nimodipine vs. pizotifen in common migraine. Results of double-blind cross-over trial. Cephalalgia 5(Suppl 3):532–533
Myrhed M, Wilholm B-E (1986) Nifedipine — a survey of side effects: four years’ reporting in Sweden. Acta Pharmacol Toxicol 133–136
Nattero G, Savi L, Delorenzo C (1985) Flunarizine in the treatment of headache with or without neurological symptoms. Cephalalgia 5(Suppl 2): 141–143
Peroutka CJ (1983) The pharmacology of calcium channel antagonists: a novel class of antimigraine agents? Headache 23:278–283
Peroutka CJ, Banghart SB, Allen GS (1984) Relative potency and selectivity of calcium antagonists used in the treatment of migraine. Headache 24:55–58
Riopelle RJ, McCans JL (1982) A pilot study of the calcium antagonist diltiazem in migraine syndrome prophylaxis. Can J Neurol Sci 9:269
Smith R, Schwartz A (1984) Diltiazem prophylaxis in refractory migraine (letter). N Engl J Med 310:1327–1328
Solomon GD, Griffith Steel MC, Spaccavento LJ (1983) Verapamil prophylaxis of migraine. JAMA 250:250–252
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© 1989 Springer-Verlag Berlin Heidelberg
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Meyer, J.S., Lotfi, J., Kobari, M. (1989). Treatment of Migraine and Cluster Headache with Calcium Antagonists. In: Hartmann, A., Kuschinsky, W. (eds) Cerebral Ischemia and Calcium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85863-5_54
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DOI: https://doi.org/10.1007/978-3-642-85863-5_54
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