Abstract
Rats develop hypertension following Skelton’s treatment, i.e., (a) unilateral adrenalectomy and contralateral adrenal enucleation, (b) unilateral nephrectomy, and (c) administration of 1% NaCl with the drinking fluid (Skelton 1959). The pathogenesis of Skelton hypertension is still obscure. But in this hypertension model the adrenal operation (a) can be substituted by stress (Deane and McKibbin 1946) due to pantothenic acid deficiency (Schwabedal et al. 1985) and the nephrectomy (b) by means of a slight reduction in the kidney blood perfusion (Schwabedal 1987 a, 1988 a).
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References
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© 1989 Springer-Verlag Berlin Heidelberg
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Schwabedal, P.E. (1989). Suppression of Brain and Adrenal Gland Arteriosclerosis by Calcium Antagonism in Hypertensive Rats (Skelton Hypertension). In: Hartmann, A., Kuschinsky, W. (eds) Cerebral Ischemia and Calcium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85863-5_41
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DOI: https://doi.org/10.1007/978-3-642-85863-5_41
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