Cellular Movements and Distribution of Calcium

  • T. Peters
Conference paper

Abstract

According to present knowledge any physiological or pharmacological stimulus somewhere in the chain of events occurring between fixation of an agent to its binding sites or receptor and final response requires ionized calcium (Ca2+) as a mediator (ionic messenger). This concerns a variety of physiological events like smooth, skeletal, and heart muscle contraction, exocytosis, phagocytosis, axonal transport, cell shape changes, cilial movement, cell division, sperm motility, conductance changes for other ions and for calcium itself, and regulation of metabolic activities (e.g., lipase and protein kinase activation), to give only a few examples. Proper physiological activation is, however, bound to a graded cytosolic increase of Ca2+ of well-controlled duration.

Keywords

Permeability Toxicity Ischemia Lipase Cytosol 

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References

  1. Allen DG, Blinks JR (1978) Calcium transients in aequorin-injected frog cardiac muscle. Nature 273:509–513PubMedCrossRefGoogle Scholar
  2. Ashley CC, Ridgway EB (1970) On the relationship between membrane potential, calcium transient and tension in single barnacle muscle fibres. J Physiol (Lond) 209:105–130Google Scholar
  3. Baker PF (1976) The regulation of intracellular calcium. Symp Soc Exp Biol 30:67–88Google Scholar
  4. Baker PF (1978) The regulation of intracellular calcium in giant axons of loligo and myxicola. Ann NY Acad Sci 307:250–268PubMedCrossRefGoogle Scholar
  5. Baker PF, Schlaepfer WW (1975) Calcium uptake by axoplasm extruded from giant axons of loligo. J Physiol 249:37–38Google Scholar
  6. Baker PF, Schlaepfer WW (1978) Uptake and binding of calcium by axoplasm isolated from giant axons of loligo and myxicola. J Physiol 276:103–125PubMedGoogle Scholar
  7. Baker PF, Umbach JA (1987) Calcium buffering in axons and axoplasm of loligo. J Physiol 383:369–394PubMedGoogle Scholar
  8. Benga MP (1985) Structure and properties of cell membranes, vol. I, II, III. Benga G (ed). CRC Press, Boca RatonGoogle Scholar
  9. Blaustein MP (1974) Interrelationships between sodium and calcium fluxes across cell membranes. Rev Physiol Biochem Pharmacol 70:33–82PubMedCrossRefGoogle Scholar
  10. Blinks JR, Rüdel R, Taylor SR (1978) Calcium transients in isolated amphibian skeletal muscles. J Physiol (Lond) 277:291–323Google Scholar
  11. Bygrave FL (1977) Mitochondrial calcium transport. Curr Top Bioenerg 6:260–318Google Scholar
  12. Campbell AK (1985) Intracellular calcium, its universal role as regulator. Wiley, ChichesterGoogle Scholar
  13. Carafoli E, Crompton M (1976) Calcium ion and mitochondria. Symp Soc Exp Biol 30:89–115Google Scholar
  14. Caroni P, Zurini M, Clark A, Carafoli E (1983) Further characterization and reconstitution of the purified Ca2+-pumping ATPase of heart sarcolemma. J Biol Chem 258:7305PubMedGoogle Scholar
  15. Catteral WA, Hartshorne RP, Beneski DA (1982) Molecular properties of neurotoxin receptor sites associated with sodium channels from mammalian brain. Toxicon 20:27–40CrossRefGoogle Scholar
  16. Cavero I, Spedding M (1983) “Calcium antagonists”: a class of drugs with a bright future. Part I. Cellular calcium homeostasis and calcium as a coupling messenger. Life Sci 33:2571–2581PubMedCrossRefGoogle Scholar
  17. Cullis PR, Kruijff B de, Hope MJ, Nayar R, Schmid SL (1980) Phospholipids and membrane transport. Can J Biochem 58:1091–1100PubMedGoogle Scholar
  18. Di Polo R (1978) Ca pump driven by ATP in squid axons? Nature 274:340Google Scholar
  19. Ebashi S (1960) Calcium binding and relaxation in actomysin system. J Biochem 48:150–151Google Scholar
  20. Ebashi S (1961) Calcium binding activity of vesicular relaxing factor. J Biochem 50:236–244Google Scholar
  21. Eisner DA, Lederer WJ, Vaughn-Jones RD (1984) The quantitative relationship between twitch tension and intracellular sodium activity. J Physiol 355:251–266PubMedGoogle Scholar
  22. Endo (1977) Calcium release from the sarcoplasmic reticulum. Physiol Rev 57:71–108PubMedGoogle Scholar
  23. Fay FS, Shelvin HH, Granger WC, Taylor SR (1979) Aequorin luminescense during activation of single isolated smooth muscle cells. Nature 280:506–508PubMedCrossRefGoogle Scholar
  24. Glitsch HG, Reuter H, Scholz H (1969) Influence of intracellular sodium concentrations on calcium influx of isolated guinea-pig auricles. Arch Pharmakol 264:236–237CrossRefGoogle Scholar
  25. Hasselbach W (1963) Relaxing factor and the relaxation of muscle. Prog Biophys Mol Biol 14:167–222CrossRefGoogle Scholar
  26. Heers C, Scheufler E, Wilhelm D, Wermelskirchen D, Wilffert B, Peters T (1988) The antiarrythmic effects of R 56865 in cardiac glycoside toxicity are not caused by inhibition of receptor binding. Br J Pharmacol 93:273PGoogle Scholar
  27. Hescheler J, Rosenthal W, Trautwein W, Schultz G (1987) The GTP-binding protein, Go, regulates neuronal calcium channels. Nature 325:445–447PubMedCrossRefGoogle Scholar
  28. Hess P, Tsien RW (1984) Mechanism of ion permeation through calcium channels. Nature 309:453–456PubMedCrossRefGoogle Scholar
  29. Kalix P (1977) Uptake and release of calcium in rabbit vagus nerve. Pflügers Arch 326:1–14CrossRefGoogle Scholar
  30. Latorre R, Coronado R, Vergara C (1984) K+-channels gated by voltage and ions. Ann Rev Physiol 46:485–495CrossRefGoogle Scholar
  31. Lee CO (1985) 200 years of digitalis: the emerging central role of the sodium ion in the control of cardiac force. Am J Physiol 249:C367–C378PubMedGoogle Scholar
  32. Lee CO, Taylor A, Windhager EC (1980) Cytosolic calcium ion activity in epithelial cells of necturus kidney. Nature 287:859–861PubMedCrossRefGoogle Scholar
  33. Lee H-C, Smith N, Mohabir R, Clusin WT (1987) Cytosolic calcium transients from the beating mammalian heart. Proc Natl Acad Sci USA 84:7793–7797PubMedCrossRefGoogle Scholar
  34. Lüllmann H, Peters T (1976) On the sarcolemmal site of action of cardiac glycosides. In Roy, Dhalla (eds) Recent advances in studies on cardiac structure and metabolism, vol 9. The sarcolemma. University Park Press, Baltimore, pp 311–328Google Scholar
  35. Lüllmann H, Peters T (1977) Plasmalemmal calcium in cardiac excitation-contraction coupling. Clin Exp Pharmacol Physiol 4:49–57PubMedCrossRefGoogle Scholar
  36. Lüllmann H, Peters T, Preuner J (1983) Role of the plasmalemma for calcium homeostasis and for excitation-contraction coupling in cardiac muscle. In: Drake, Holland, Noble (eds) Cardiac metabolism. Wiley, Chichester, pp 1–18Google Scholar
  37. Manery JF (1969) Calcium and membranes. In: Comer, Bronner (eds) Mineral metabolism, vol 3. Academic Press, New York, pp 405–452Google Scholar
  38. Marban E, Tsien RW (1982) Enhancement of Ca-current during digitalis inotropy. J Physiol 329:589–614PubMedGoogle Scholar
  39. Moore CL (1971) Specific inhibition of mitochondrial calcium transport by ruthenium red. Biochem Biophys Res Commun 42:298–305PubMedCrossRefGoogle Scholar
  40. Narahashi T, Tsunoo A, Yoshii M (1987) Characterization of two types of calcium channels in mouse neuroblastoma cells. J Physiol 383:231–249PubMedGoogle Scholar
  41. Portzehl H, Caldwell PC, Rüegg JC (1964) The dependence of contraction and relaxation of muscle fibres from the crab Maia squinado on the internal concentration of free calcium ions. Biochim Biophys Acta 79:581–591PubMedGoogle Scholar
  42. Post JA, Langer GA, Op den Kamp JAF, Verkleij AJ (in press) Phospholipid asymmetry in cardiac sarcolemma. Biochim Biophys ActaGoogle Scholar
  43. Preuner J (1981) Ca-homeostasis in cardiac muscle cell: an active Ca-pump and its functional dependence on plasma membrane bound Ca. Arch Pharmacol 316:30Google Scholar
  44. Reuter H (1986) Voltage-dependent mechanisms for raising intracellular free calcium concentration: calcium channels. In: Calcium and the cell (Ciba Foundation Symposium 122). Wiley, Chichester, pp 5–22Google Scholar
  45. Reuter H, Blaustein MP, Haeusler G (1973) Na-Ca-exchange and tension development in arterial smooth muscle. Phil Trans R Soc 265:87–94CrossRefGoogle Scholar
  46. Rosenberg RL, Hess P, Reeves JP, Smilowitz H, Tsien RW (1986) Calcium channels in planar lipid bilayers: insights into mechanisms of ion permeation and gating. Science 231:1564–1566PubMedCrossRefGoogle Scholar
  47. Rudel R (1979) In: Ashley, Campbell (eds) Detection and measurement of free Ca++ in cells. Elsevier/North-Holland, Amsterdam, pp 153–158Google Scholar
  48. Schatzmann HJ (1966) ATP-dependent Ca++-extrusion from human red cells. Experientia 22:364PubMedCrossRefGoogle Scholar
  49. Schneider J, Beck E, Wilffert B, Peters T (1988) A dose-dependent inhibition of digitalis-induced toxicity by R 56865 in the guinea-pig heart-lung preparation. Br J Pharmacol 93:272PGoogle Scholar
  50. Seimiya T, Ohki S (1973) Ionic structure of phospholipid membranes, and binding of calcium ions. Biochim Biophys Acta 298:546–561PubMedCrossRefGoogle Scholar
  51. Siesjö BK (1985) Oxygen deficiency and brain damage: Localization, evolution in time, and mechanism of damage. Clin Tox 23:4–6Google Scholar
  52. Stahl WL, Swanson PD (1972) Calcium movements in brain slices in low sodium or calcium media. J Neurochem 19:2395–2407PubMedCrossRefGoogle Scholar
  53. Vincenzi FF, Schatzmann HJ (1967) Some properties of Ca-activated ATPase in human red cells. Helv Physiol Pharmacol Acta 25:233Google Scholar
  54. Vollmer B, Meuter C, Janssen PAJ (1987) R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle. Eur J Pharmacol 142:137–140PubMedCrossRefGoogle Scholar
  55. Yeagle P (1987) The membranes of cells. Academic Press, New YorkGoogle Scholar
  56. Yoshikawa K, Fujimoto T, Shimooka T, Terada H, Kumazawa N, Ishii T (1988) Electrical oscillation and fluctuation in phospholipid membranes. Phospholipids can form a channel without protein. Biophys Chem 29:293–299PubMedCrossRefGoogle Scholar
  57. Zwaal RFA, Roelofsen B, Colley CM (1973) Localization of red cell membrane constituents. Biochim Biophys Acta 300:159–183PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • T. Peters
    • 1
  1. 1.Department of Experimental MedicineJanssen Research FoundationNeuss 21Germany

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