Calcium 45 Accumulation in the Dentate Hilus: Possible Effect of NMDA Receptor Blockers

  • H. Benveniste
  • P. C. Hüttemeier
  • F. F. Johansen
  • N. H. Diemer

Abstract

Among the many complex reactions involved in ischemia-induced neuronal cell injury, intracellular calcium accumulation appears to be particularly cytotoxic [11, 19, 24]. The rise in the intracellular calcium concentration has been postulated to initiate or represent a “final common pathway” for cell death [23]. The mechanisms of intracellular calcium accumulation during neuronal injury are the result of several factors, but one source might be the opening of postsynaptic NMDA receptor-coupled calcium channels by excessive transmitter release of glutamate and aspartate [2].

Keywords

Catheter Magnesium Ischemia Polyethylene NMDA 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. Benveniste
    • 1
  • P. C. Hüttemeier
    • 2
  • F. F. Johansen
    • 1
  • N. H. Diemer
    • 1
  1. 1.PharmaBioTec Research Center, Institute of NeuropathologyUniversity of CopenhagenCopenhagenDenmark
  2. 2.Department of Anesthesiology, Glostrup HospitalUniversity of CopenhagenCopenhagenDenmark

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